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Abstract

A novel drug delivery concept based on the encapsulation of liposomes in biodegradable dextran-based microspheres was designed. The system released the liposomes in intact form in a controlled way after a prolonged period of time.

A Review on Composite Liposomal Technologies for Specialized Drug Delivery

“…Polymer-based systems, such as hydrogel or prefabricated scaffolds have been used as depots for drugs, regenerative cells, protein, growth factor, and pre-encapsulated drug-loaded liposome for sustained release [8, 12, 81–85]. Various polymers have been researched for this application based on their fundamental properties such as biodegradability, biocompatibility, nontoxicity, and the noninflammatory tendency.…”

“…However, the benefit on sustained release for the pre-encapsulated drug loaded scaffold over a long period of time has been reported and declared successful [96]. Stenekes and coworkers [8] demonstrated that liposome embedded inside a biodegaradble depot polymeric scaffold was able to sustained drug release over a prolonged period of time (Figure 8). In addition, the released liposome was found intact after many days storage within the inside depot polymeric scaffold.…”

“…The first approach involves modification of the surface of liposomes with hydrophilic polymers such polyethylene glycol (PEG) while the second one is to integrate the pre-encapsulated drug-loaded liposomes within depot polymer-based systems [3]. A study conducted by Stenekes and coworkers [8] reported the success of using temporary depot of polymeric materials to control the release of the loaded liposomes for pharmaceutical applications. This achievement leads to new applications, which requires collaborative research among pharmaceuticals, biomaterials, chemistry, molecular, and cell biology.…”

Core/Shell Nanoparticles for Drug Delivery and Diagnosis

“…The interaction between phospholipids and polymers was firstly utilized in the design of microparticles with core/shell structures and characterized as a form of microencapsulated liposomes [95][96][97]. Polymers such as dextran, chitosan, and sodium alginate were used as capsule materials.…”

Optimization of calcium pectinate gel beads for sustained-release of catechin using response surface methodology

“…This limitation could be overcome by reinforcing CPG beads with liposomes, spherical closed nanostructures composed of lipid bilayers, which can encapsulate active agents within their interior. Liposomes loaded with active agents have been entrapped within several types of polysaccharide gel beads based on alginate, chitosan, and dextran [14][15][16][17][18]. These liposomeentrapped gel beads, compared to gel beads or liposomes alone, showed more sustained patterns of drug release, because active agents are enclosed within compact liposomal membrane and the liposomes are more stabilized within the matrices of gel beads [16,17,[19][20][21].…”