Yellow‐white fluorescence on the nails: A novel finding of Favipiravir used for the treatment of COVID‐19

Gülseren, Duygu; Yalıcı-Armağan, Başak

doi:10.1111/jocd.14214

Cited by 8 publications

(16 citation statements)

References 5 publications

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“…They observed no such sign in their fifth patient who did not receive favipravir. Gülseren et al 7 reported 3 patients with COVID‐19, who had yellow–white fluorescence in their fingernails. Their 4th case who recovered without systemic therapy, had no fluorescence in his fingernails.…”

Section: Discussionmentioning

confidence: 99%

Nail and hair findings developing in patients treated for COVID‐19 infection fluorescence of keratinized tissues on Wood’s lamp in COVID‐19 disease

Çoban

Durusoy

2022

J of Cosmetic Dermatology

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Background:The new severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the causative agent of coronavirus 2019 (COVID-2019) disease. A wide variety of symptoms of the disease has been frequently reported in the literature in recent years. However, information on the findings in keratinized tissues is still limited. Data on changes in keratinized tissues such as nails, teeth and hair, and oral mucousa due to drugs used in the treatment of this disease are also extremely insufficient.Aim: With this study, it was aimed to evaluate the changes in the keratinized tissues of our patients with COVID-19, who are frequently encountered in the Ear Nose and Throat outpatient clinic. Materials and Method:The study was carried out on patients who applied to Başkent University Ear Nose and Throat clinic. There were 3 groups. The first group consisted of patients diagnosed with COVID-19 and received relevant medical treatments, the second group included individuals who have never experienced COVID-19 infection but have been vaccinated against COVID-19, and the third group is the control group with normal healthy individuals who have never been diagnosed with COVID-19 infection and have not been vaccinated so far. With the Wood's lamp, fluorescent changes in nails, hair, tooth, and the oral mucousa were recorded.Results: A total of 124(75 females, 49 males) patients were included in the study. Positive Wood's finding was significantly higher in COVID-19 group(Group 1) who received Favipravir when compared with individuals who did not receive Favipravir (p < 0.001). Wood's positivity was not detected in any of the individuals who did not use favipravir. The rate of determining Wood's positivity in favipravir users decreases after 58 days.Discussion: Accordingly, Favipravir accumulation in the kretainized tissues manifest positive Wood's sign in our study. Conclusion:The adverse effects of the accumulation of the drugs-mainly Favipravirused in the treatment of COVID-19 disease, have not yet been clearly demonstrated so far. Revealing the findings in these tissues with this study will pave the way for investigating changes or drug sequestrations in other organs in the long term.

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Section: Discussionmentioning

confidence: 99%

Nail and hair findings developing in patients treated for COVID‐19 infection fluorescence of keratinized tissues on Wood’s lamp in COVID‐19 disease

Çoban

Durusoy

2022

J of Cosmetic Dermatology

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“…A yellow-white fluorescence on the nails has been reported as an adverse event of favipiravir used for COVID-19 disease. 35 Some patients on favipiravir developed a greenish fluorescence in the lunula and nail plate portion near the proximal nail fold. Green fluorescence has also been observed on the scalp hair made visible by Wood's lamp illumination.…”

Section: Nail Changes Induced By Covid-19 Treatmentsmentioning

confidence: 99%

“…It is used in COVID‐19 off‐label with variable results. A yellow‐white fluorescence on the nails has been reported as an adverse event of favipiravir used for COVID‐19 disease 35 …”

Section: Nail Changes Induced By Sars‐cov‐2 Infectionmentioning

confidence: 99%

Nails and COVID ‐19 – A comprehensive review of clinical findings and treatment

Wollina

Kanitakis

Baran

2021

Dermatologic Therapy

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The SARS‐CoV‐2 infection, responsible for COVID‐19, has raised the interest for infection‐associated muco‐cutaneous symptoms. While dermatologic symptoms in general gained an increasing awareness, affection of the nail organ has been mentioned only recently. We provide a narrative review on COVID‐19 manifestation on the nail organ and add symptoms induced by personal protective measures and SARS‐CoV‐2 vaccination. Available treatment options are discussed.

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“… 6 Gulseren et al reported yellow‐white fluorescence in the nails of the patients with COVID‐19 and they attributed this appearance to the drugs used in the treatment of COVID‐19 through as yet unclear mechanisms. 7 The current study presents Wood's lamp examination images of hair and nails of patients who presented to dermatology outpatient clinic for various reasons and who had received favipiravir therapy for COVID‐19.…”

Section: Figurementioning

confidence: 99%

Wood's lamp examination of hair and nails related to COVID‐19 treatment

Demir

Çiçek

Turkoglu

et al. 2021

Dermatologic Therapy

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Dear Editor, Favipiravir, (6-fluoro-3-hydroxy-2-pyrazine carboxamide) the drug which is being used in the treatment of COVID-19 is a broadspectrum antiviral agent. The drug is converted to its active phosphorylated form in the cells, and it inhibits viral RNA polymerase activity. 1 The main organs that favipiravir being distributed are the lungs, kidneys, spleen, and brain. 2 Among the cutaneous side-

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Yellow‐white fluorescence on the nails: A novel finding of Favipiravir used for the treatment of COVID‐19

Cited by 8 publications

References 5 publications

Nail and hair findings developing in patients treated for COVID‐19 infection fluorescence of keratinized tissues on Wood’s lamp in COVID‐19 disease

Nail and hair findings developing in patients treated for COVID‐19 infection fluorescence of keratinized tissues on Wood’s lamp in COVID‐19 disease

Nails and COVID ‐19 – A comprehensive review of clinical findings and treatment

Wood's lamp examination of hair and nails related to COVID‐19 treatment

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