Yellow nails. A report of six cases

Marks, R.

doi:10.1001/archderm.102.6.619

Cited by 14 publications

(9 citation statements)

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“…Four YNS patients underwent lower limb direct lymphangiography, less used at present, but lymphatic abnormalities were noted only in the patient with severe lymphedema. Quantitative limb lymphoscintigraphy with 99m Tc-colloidal antimony sulfide revealed less activity (percentage uptake) in the draining lymph nodes (inguinofemoral or axillary) [ 41 ]. Moreover, the uptake percentages in the axillary/inguinal lymph nodes of the YNS group were significantly lower than those of the normal controls but significantly higher than those of subjects with primary or secondary lymphedema, hence more suggestive of impaired lymph transport than the lymphatic hypoplasia/aplasia seen in true primary lymphedema.…”

Section: Pathogenesismentioning

confidence: 99%

Yellow nail syndrome: a review

Vignes¹,

Baran

2017

Orphanet J Rare Dis

114

161

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Yellow nail syndrome (YNS; OMIM 153300, ORPHA662) is a very rare disorder that almost always occurs after 50 years of age but a juvenile or familial form has also been observed. YNS is diagnosed based on a triad associating yellow nail discoloration, pulmonary manifestations (chronic cough, bronchiectasia, pleural effusion) and lower limb lymphedema. Chronic sinusitis is frequently associated with the triad. YNS etiology remains unknown but a role of lymphatic impairment is usually evoked. YNS is more frequently isolated but may be associated in rare cases with autoimmune diseases, other clinical manifestations implicating lymphatic functions or cancer and, hence, is also considered a paraneoplastic syndrome. YNS management is symptomatic and not codified. YNS can resolve spontaneously. Oral vitamin E alone or even better when associated with triazole antifungals may achieve partial or total disappearance of nail discoloration. Pleural effusion can be treated surgically, with decortication/pleurectomy or pleurodesis. Antibiotic prophylaxis is prescribed for bronchiectasia with chronic sputum production. Lymphedema treatment is based on low-stretch bandages and the wearing of elastic compression garments combined with skin care, exercises and, as needed, manual lymph drainage.

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Section: Pathogenesismentioning

confidence: 99%

Yellow nail syndrome: a review

Vignes¹,

Baran

2017

Orphanet J Rare Dis

114

161

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“…Although the etiology of YNS is poorly understood, disorder of lymphatic drainage is thought to be involved in the pathogenesis of YNS (5, 6), which is often evoked to explain lymphedema, pleural effusion, slow growth of nail or nail discoloration (2). However it is difficult to explain the pulmonary parenchymal manifestations, which are diverse including bronchiectasis and localized parenchymal infiltrates (3).…”

Section: Discussionmentioning

confidence: 99%

Yellow Nail Syndrome Patients with Diffuse Panbronchiolitis-like Pulmonary Manifestation

et al. 2019

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Yellow nail syndrome (YNS) is a rare clinical syndrome characterized by a triad of yellow thick nail, lymphedema and respiratory diseases. We experienced 2 cases of YNS with diffuse panbronchiolitis (DPB)-like pulmonary manifestation. Since YNS might be hidden to those who have been diagnosed with DPB, physicians should be alert to recognize nail signs of YNS in case of DPB refractory to macrolide therapy. We hereby review previous case reports of YNS and discuss its pulmonary manifestations.

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“…YNS has been associated with a variety of diseases (17). Th e most common conditions associated with YNS include malignant diseases -melanoma (3), bronchogenic carcinoma (35), thoracic carcinoma (36) renal cell carcinoma (37); lymphproliferative diseases (38,39); immune defi ciency conditions (39), acquired immunodefi ciency syndrome (40); endocrine diseases (25,40,41,42); connective tissue diseases (10,43,44); obstructive sleep apnea (45); xanthogranulomatous pyelonephritis (46), nephrotic syndrome (47), membranous glomerulonephritis (24), tuberculosis (48) post-myocardial infarction (49), pericardial eff usion (50), asthma (42). YNS has been reported after treatment with sodium valproate, D-penicillamine (51), and gold sodium thiomalate in the treatment of rheumatoid arthritis (52).…”

Section: Discussionmentioning

confidence: 99%

Yellow Nail Syndrome - a Case Report

Paravina

Binić

Popović

et al. 2015

Serbian Journal of Dermatology and Venereology

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Yellow nail syndrome (YNS) is characterized by yellowish nails, lymphedema, sinusitis, and pulmonary involvement and can be triggered by various underlying conditions, such as sinusitis or titanium exposure from an artificial joint or dental implant. Since YNS is potentially treatable, its timely diagnosis is important. The authors recently experienced a case of YNS in a patient who developed sinusitis, yellowish nails, bilateral edema of the extremities, and subclinical rheumatoid arthritis after the implantation of a cardiac pacemaker made from titanium. This case may be the first report of YNS induced by a titanium cardiac pacemaker. A 65-year-old Japanese man developed edema of the face, bilateral hands and forearms, stiffness of the fingers of both hands, an abnormal sensation that affected the whole body, and generalized rash, in the month after the implantation of a cardiac pacemaker for complete atrioventricular block. The implanted pacing system was composed of a Medtronic Ad-visa MRI™ and CapSureFix MRI™ (Medtronic, Minneapo-lis, USA) leads; the body of the pacemaker was made from titanium, while the tip of the lead was coated in titanium. The patient's medical history included hypertension and right carotid artery stenosis with asymptomatic right cerebral stroke. After undergoing carotid endarterectomy, the patient developed atrioventricular block and a permanent cardiac pacemaker was implanted. After right carotid endarterec-tomy, the stent was not placed. When the patient was diagnosed with stroke, he started to take the following medications: low-dose aspirin, clopido-grel, candesartan, pitavastatin, amlodipine, lansoprazole, and eicosapentaenoic acid. On examination, the patient was alert, hemodynamically stable and afebrile. The abnormal physical findings included yellow-colored fingernails (Fig. 1) and (all) toenails, fine crackles at the lung bases, and swelling of the forearms and hands; the extent of the swelling on the left side was greater than that on the right side (Fig. 2). Blood tests showed normal a leukocyte count and C-reactive protein level and were negative for antinuclear anti-bodies, rheumatoid factor, and anti-cyclic citrullinated pep-tide (CCP) antibodies. The erythrocyte sedimentation rate was 32 mm/h. Spirometry showed no evidence of obstructive or restrictive disease. Whole-body contrast-enhanced CT showed no pulmonary lesions, pleural effusion or any findings suggestive of malig-nancy. Upper gastrointestinal endoscopy and colonoscopy showed no evidence of neoplasms. A hand radiograph indicated mild bone erosion of the hands, which was predominant at the metacarpophalangeal joints. Echography of the joints revealed the thickening of the synovial membranes around the carpal bones with increased blood flow, suggesting the presence of synovitis. Head MRI showed bilateral maxillary sinusitis. Based on the yellow nails and diffuse edema as well as the symptoms and signs in relation to the patient's paranasal sinuses and joints, yellow nail syndrome (YNS) along with sinusitis and ...

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Yellow nails. A report of six cases

Cited by 14 publications

References 0 publications

Yellow nail syndrome: a review

Yellow nail syndrome: a review

Yellow Nail Syndrome Patients with Diffuse Panbronchiolitis-like Pulmonary Manifestation

Yellow Nail Syndrome - a Case Report

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