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Cited by 19 publications
(4 citation statements)
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“…Their answer was to create an orthogonal suppressor tRNA/aminoacyl-tRNA synthetase (aaRS) pair. In a seminal study published in 1981, Martin et al showed that coinjection of yeast mitochondrial tRNA and bacterial aaRS into Xenopus oocytes led to the readthrough of the opal codon through the insertion of a tryptophan . This discovery implied that the suppressor tRNA/aaRS pairs could function in the heterologous host cells.…”
Section: Labeling Of Gpcrs With Biophysical Probesmentioning
confidence: 99%
See 1 more Smart Citation
“…Their answer was to create an orthogonal suppressor tRNA/aminoacyl-tRNA synthetase (aaRS) pair. In a seminal study published in 1981, Martin et al showed that coinjection of yeast mitochondrial tRNA and bacterial aaRS into Xenopus oocytes led to the readthrough of the opal codon through the insertion of a tryptophan . This discovery implied that the suppressor tRNA/aaRS pairs could function in the heterologous host cells.…”
Section: Labeling Of Gpcrs With Biophysical Probesmentioning
confidence: 99%
“…In a seminal study published in 1981, Martin et al showed that coinjection of yeast mitochondrial tRNA and bacterial aaRS into Xenopus oocytes led to the readthrough of the opal codon through the insertion of a tryptophan. 418 This discovery implied that the suppressor tRNA/aaRS pairs could function in the heterologous host cells. In human complete protein coding genes, the amber codon is the least frequently utilized one among the three stop codons (amber, 23.5%; ochre, 29.4%, opal, 47.1%).…”
Section: Chemoenzymatic Labeling Based On Posttranslational Modificat...mentioning
confidence: 99%
“…The system’s flexibility arises from the facile attachment of dinucleotide-amino acid substrates to truncated tRNA via enzymatic ligation 4 . That is, the same species of tRNA can be used for encoding the amino acid needed for the experimental inquiry, in contrast to co-injecting an aminoacyl-tRNA synthetase for ncAA aminoacylation 5 7 . For this reason, chemical acylation of tRNAs is widely used for genetic code expansion in Xenopus oocytes.…”
Section: Introductionmentioning
confidence: 99%
“…This conclusion was reached because, for each reporter mRNA translated in presence of the C. albicans ser-tRNA CAG abnormally elongated polypeptides were synthesized which could be separated from the wild-type polypeptides on SDS-PAGE. tRNAs able to translate one of the three stop codons have been isolated from a number of prokaryotes and eukaryotes (Hirsh and Gold, 1971;Geller and Rich, 1980;Van Tol et al, 1980;Morch and Benicourt, 1980;Martin et al, 1981;Diamond et al, 1981;Bienz and Kubli, 1981;Tuite and McLaughlin, 1982). However, no tRNA with a 5k-CAG-3k anticodon capable of translating both UAG and UGA stop codons has been described from any organism, and standard wobble rules are unable to explain this unusual decoding property.…”
Section: Introductionmentioning
confidence: 99%