Yb,Nd,Er-doped upconversion nanoparticles: 980 nm <i>versus</i> 808 nm excitation

Wiesholler, Lisa M.; Frenzel, Florian; Grauel, Bettina; Würth, Christian; Resch‐Genger, Ute; Hirsch, Thomas

doi:10.1039/c9nr03127h

Cited by 82 publications

(58 citation statements)

References 55 publications

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“…It was found that when Nd 3+ is codoped with Yb 3+ and activator into a UCNP matrix, the nanoparticles can be excited at both 808 and 980 nm (Lai et al, 2014;Chen et al, 2015). Excitation of Nd 3+ -sensitized UCNPs at 808 nm benefits from minimal photothermal effects and provides deeper living tissue penetration compared to that of conventional 980 nm excitation (Wang et al, 2014;Wiesholler et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Monodisperse Core-Shell NaYF4:Yb3+/Er3+@NaYF4:Nd3+-PEG-GGGRGDSGGGY-NH2 Nanoparticles Excitable at 808 and 980 nm: Design, Surface Engineering, and Application in Life Sciences

et al. 2020

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4 :Nd 3+-PEG-RGDS nanoparticles on both Hep-G2 and HeLa cells was determined, confirming no adverse effect on their survival and proliferation. The interaction of the nanoparticles with Hep-G2 cells was monitored by confocal microscopy at both 808 and 980 nm excitation. The NaYF 4 :Yb 3+ /Er 3+ @NaYF 4 :Nd 3+-PEG-RGDS nanoparticles were localized on the cell membranes due to specific binding of the RGDS peptide to integrins, in contrast to the NaYF 4 :Yb 3+ /Er 3+ @NaYF 4 :Nd 3+-PEG-Alk particles, which were not engulfed by the cells. The NaYF 4 :Yb 3+ /Er 3+ @NaYF 4 :Nd 3+-PEG-RGDS nanoparticles thus appear to be promising as a new non-invasive probe for specific bioimaging of cells and tissues. This development makes the nanoparticles useful for diagnostic and/or, after immobilization of a bioactive compound, even theranostic applications in the treatment of various fatal diseases.

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Section: Introductionmentioning

confidence: 99%

Monodisperse Core-Shell NaYF4:Yb3+/Er3+@NaYF4:Nd3+-PEG-GGGRGDSGGGY-NH2 Nanoparticles Excitable at 808 and 980 nm: Design, Surface Engineering, and Application in Life Sciences

et al. 2020

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“…In addition, 980 nm light can resonantly excite Yb 3+ ions and further pump Er 3+ and Tm 3+ ions through nonradiative energy transfers, resulting in yellowish upconversion emissions. Under 808 nm excitation, Nd 3+ ions in the outer shell dominate the absorption and migrate the energy to Yb 3+ ions and subsequently to Tm 3+ ions, giving rise to blue-violet and red emissions 33 . The inert layer of NaYF 4 acts to prevent cross talk between the two emissive areas (the core and the outer shell) 34 .…”

Section: Resultsmentioning

confidence: 99%

Huge upconversion luminescence enhancement by a cascade optical field modulation strategy facilitating selective multispectral narrow-band near-infrared photodetection

Ding

et al. 2020

Light Sci Appl

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Since selective detection of multiple narrow spectral bands in the near-infrared (NIR) region still poses a fundamental challenge, we have, in this work, developed NIR photodetectors (PDs) using photon upconversion nanocrystals (UCNCs) combined with perovskite films. To conquer the relatively high pumping threshold of UCNCs, we designed a novel cascade optical field modulation strategy to boost upconversion luminescence (UCL) by cascading the superlensing effect of dielectric microlens arrays and the plasmonic effect of gold nanorods, which readily leads to a UCL enhancement by more than four orders of magnitude under weak light irradiation. By accommodating multiple optically active lanthanide ions in a core-shell-shell hierarchical architecture, developed PDs on top of this structure can detect three well-separated narrow bands in the NIR region, i.e., those centered at 808, 980, and 1540 nm. Due to the large UCL enhancement, the obtained PDs demonstrate extremely high responsivities of 30.73, 23.15, and 12.20 A W−1 and detectivities of 5.36, 3.45, and 1.91 × 1011 Jones for 808, 980, and 1540 nm light detection, respectively, together with short response times in the range of 80–120 ms. Moreover, we demonstrate for the first time that the response to the excitation modulation frequency of a PD can be employed to discriminate the incident light wavelength. We believe that our work provides novel insight for developing NIR PDs and that it can spur the development of other applications using upconversion nanotechnology.

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“…22,23 For PTT use, 808 nm UCNs are preferred over 980 nm UCNs due to the lower water absorption and deeper tissue penetration of light at the former wavelength. 24,25 However, UCNs are not a good agent for direct use in PTT due to their limited absorption of light. Although UCNs can absorb near-infrared light and emit visual light under irradiation, their absorption is still low for PTT.…”

Section: Introductionmentioning

confidence: 99%

<p>Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy</p>

Wei¹,

Liu²,

Pan³

et al. 2020

IJN

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Background: Photothermal therapy with accurate and real-time temperature detection is desired in clinic. Upconversion nanocrystals (UCNs) are candidate materials for simultaneous temperature detection and photothermal agents carrying. However, the weak luminescence and multiple laser excitations of UCNs limit their application in thermal therapy. Materials and Methods: NaYF 4 :Yb 3+ ,Er 3+ ,Nd 3+ , PL-PEG-NH 2 , IR-806 and folic acid are selected as structural components. A nanoprobe (NP) integrated with efficient photothermal conversion and sensitive temperature detection capabilities is synthesized for precise photothermal therapy. The probes are based on near-infrared upconversion nanocrystals doped with Yb, Er and Nd ions, which can be excited by 808 nm light. IR-806 dye molecules are modified on the surface as molecular antennas to strongly absorb near-infrared photons for energy transfer and conversion. Results: The results show that under an 808 nm laser irradiation upconversion luminescence of the nanocrystals is enhanced based on both the Nd ion absorption and the FRET energy transfer of IR-806. The luminescence ratio at 520 and 545 nm is calculated to accurately monitor the temperature of the nanoparticles. The temperature of the nanoprobes increases significantly through energy conversion of the molecular antennas. The nanoparticles are found successfully distributed to tumor cells and tumor tissue due to the modification of the biocompatible molecules on the surface. Tumor cells can be killed efficiently based on the photothermal effect of the NPs. Under the laser irradiation, temperature at mouse tumor site increases significantly, tissue necrosis and tumor cell death can be observed. Conclusion: Precision photothermal therapy can thus be achieved by highly efficient nearinfrared light absorption and accurate temperature monitoring, making it promising for tumor treatment, as well as the biological microzone temperature detection.

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Yb,Nd,Er-doped upconversion nanoparticles: 980 nm versus 808 nm excitation

Abstract: A set of similarly sized (Yb3+, Nd3+, Er3+)-doped upconversion nanoparticles of different architecture were spectroscopically examined in water at broadly varied excitation power at 980 nm & 808 nm to study the sensitizer dependent penetration-depth.

Cited by 82 publications

References 55 publications

Monodisperse Core-Shell NaYF4:Yb3+/Er3+@NaYF4:Nd3+-PEG-GGGRGDSGGGY-NH2 Nanoparticles Excitable at 808 and 980 nm: Design, Surface Engineering, and Application in Life Sciences

Monodisperse Core-Shell NaYF4:Yb3+/Er3+@NaYF4:Nd3+-PEG-GGGRGDSGGGY-NH2 Nanoparticles Excitable at 808 and 980 nm: Design, Surface Engineering, and Application in Life Sciences

Huge upconversion luminescence enhancement by a cascade optical field modulation strategy facilitating selective multispectral narrow-band near-infrared photodetection

<p>Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy</p>

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