Yanangdaengin, a dihydrochalcone glucoside galloyl ester as active antioxidative agent from leaves of Lysiphyllum strychnifolium (syn. Bauhinia strychnifolia)

Kongkiatpaiboon, Sumet; Duangdee, Nongnaphat; Tayana, Ngampuk; Schinnerl, Johann; Bacher, Markus; Chewchinda, Savita

doi:10.1016/j.chmed.2020.05.009

Cited by 10 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 2019 ; Kongkiatpaiboon et al. 2020 ), our study revealed the potent inhibitory effect of LS extract on the final state of lipid peroxidation as a consequence of ROS-induced oxidative stress. In fact, phenolic compounds consist of aromatic ring structures and hydroxyl groups, which can act as reducing agents by donating hydrogen atoms to ROS and further turn them into more neutralized radicals (Iqbal et al.…”

Section: Discussionsupporting

confidence: 58%

“… 2019 ; Kongkiatpaiboon et al. 2020 ). The hypoglycemic and antioxidant effects of the LS extract may be attributed to the integrated effect of its phytochemical active compounds.…”

Section: Discussionmentioning

confidence: 99%

“…The biomarkers, i.e., gallic acid, trilobatin and yanangdaengin in the LS extract were identified using the HPLC method based on a previous study (Kongkiatpaiboon et al. 2020 ). The Thermo HPLC system (Thermo Separation Products Inc., Waltham, MA) consisted of a vacuum solvent degasser, quaternary pump, autosampler, UV-visible diode-array detector, and a BDS Hypersil C18 column (150 mm × 4.6 mm, i.d.…”

Section: Methodsmentioning

confidence: 99%

“…The active compounds discovered from the leaves of Lysiphyllum strychnifolium (LS) include gallic acid, trilobatin and yanangdaengin (Kongkiatpaiboon et al. 2020 ). Various biological properties of LS extracts, comprising anti-cancer, antiallergic, antimicrobial, anti-inflammatory, anti-hyperuricemic, and antidote effects, have been reported (Yuenyongsawad et al.…”

Section: Introductionmentioning

confidence: 99%

“… 2019 ; Kongkiatpaiboon et al. 2020 ), as oxidative stress is closely associated with the etiology of T2DM (Burgos-Moron et al. 2019 ).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Antihyperglycemic effects of Lysiphyllum strychnifolium leaf extract in vitro and in vivo

Goli

Sato

et al. 2023

Pharmaceutical Biology

Self Cite

View full text Add to dashboard Cite

Context Lysiphyllum strychnifolium (Craib) A. Schmitz (LS) (Fabaceae) has traditionally been used to treat diabetes mellitus. Objective This study demonstrates the antidiabetic and antioxidant effects of aqueous extract of LS leaves in vivo and in vitro . Materials and methods The effects of aqueous LS leaf extract on glucose uptake, sodium-dependent glucose cotransporter 1 (SGLT1) and glucose transporter 2 (GLUT2) mRNA expression in Caco-2 cells, α-glucosidase, and lipid peroxidation were evaluated in vitro . The antidiabetic effects were evaluated using an oral glucose tolerance test (OGTT) and a 28-day consecutive administration to streptozotocin (STZ)-nicotinamide (NA)-induced type 2 diabetic mice. Results The extract significantly inhibited glucose uptake (IC 50 : 236.2 ± 36.05 µg/mL) and downregulated SGLT1 and GLUT2 mRNA expression by approximately 90% in Caco-2 cells. Furthermore, it non-competitively inhibited α-glucosidase in a concentration-dependent manner with the IC 50 and K i of 6.52 ± 0.42 and 1.32 µg/mL, respectively. The extract at 1000 mg/kg significantly reduced fasting blood glucose levels in both the OGTT and 28-day consecutive administration models as compared with untreated STZ-NA-induced diabetic mice ( p < 0.05). Significant improvements of serum insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and GLUT4 levels were observed. Furthermore, the extract markedly decreased oxidative stress markers by 37–53% reduction of superoxide dismutase 1 (SOD1) in muscle and malondialdehyde (MDA) in muscle and pancreas, which correlated with the reduction of MDA production in vitro (IC 50 : 24.80 ± 7.24 µg/mL). Conclusion The LS extract has potent antihyperglycemic activity to be used as alternative medicine to treat diabetes mellitus.

show abstract

Section: Discussionsupporting

confidence: 58%

“… 2019 ; Kongkiatpaiboon et al. 2020 ). The hypoglycemic and antioxidant effects of the LS extract may be attributed to the integrated effect of its phytochemical active compounds.…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“… 2019 ; Kongkiatpaiboon et al. 2020 ), as oxidative stress is closely associated with the etiology of T2DM (Burgos-Moron et al. 2019 ).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations