Xylan microparticles for controlled release of mesalamine: Production and physicochemical characterization

Urtiga, Silvana Cartaxo da Costa; Alves, Vitória Maria Oliveira; Melo, Camila de Oliveira; Lima, Marini Nascimento de; Souza, Ernane; Cunha, Arcelina Pacheco; Ricardo, Nágila Maria Pontes Silva; Oliveira, Elquio Eleamen; Egito, Eryvaldo Sócrates Tabosa do

doi:10.1016/j.carbpol.2020.116929

Cited by 15 publications

(2 citation statements)

References 49 publications

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“…53 In addition, it is noteworthy that the two signals found at 4.98 ppm and 5.10 ppm were related to protons attached to the hydroxyl groups at the C-3 (-C-OH, 5.1 ppm) and C-2 (-C-OH, 5.2 ppm) positions of the D-xylopyranose units in the xylan. 54,55 Additionally, the weaker signal peaks at 5.34 and 5.21 ppm correspond to the chemical shifts of the arabinose group. The 2D HSQC NMR spectra of the regenerated hemicellulose were further examined (Fig.…”

Section: Characterization Of Regenerated Hemicellulosementioning

confidence: 99%

Efficient fractionation of pure hemicellulose with high DP from bleached hardwood pulp using LiBr·3H₂O and co-production of dissolving pulp

Gong,

Liu,

et al. 2024

Green Chem.

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Section: Characterization Of Regenerated Hemicellulosementioning

confidence: 99%

Efficient fractionation of pure hemicellulose with high DP from bleached hardwood pulp using LiBr·3H₂O and co-production of dissolving pulp

Gong,

Liu,

et al. 2024

Green Chem.

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“…The xylans were extracted from corn cobs. It was found that this encapsulation had better control of the drug during different simulated gastrointestinal media in vitro and that a significant amount of the drug may be able to reach the large intestine and exert a stronger therapeutic effect in IBD [ 157 ]. Additionally, xylans isolated from corn cobs were used in the synthesis of xylan–stearic acid conjugate-based nanoparticles delivering 5-FU.…”

Section: Carriers and Encapsulates Based On Hemicellulosesmentioning

confidence: 99%

Encapsulation of Polyphenolic Compounds Based on Hemicelluloses to Enhance Treatment of Inflammatory Bowel Diseases and Colorectal Cancer

Caban

Lewandowska

2023

Molecules

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Inflammatory bowel diseases (IBD) and colorectal cancer (CRC) are difficult to cure, and available treatment is associated with troubling side effects. In addition, current therapies have limited efficacy and are characterized by high costs, and a large segment of the IBD and CRC patients are refractive to the treatment. Moreover, presently used anti-IBD therapies in the clinics are primarily aimed on the symptomatic control. That is why new agents with therapeutic potential against IBD and CRC are required. Currently, polyphenols have received great attention in the pharmaceutical industry and in medicine due to their health-promoting properties. They may exert anti-inflammatory, anti-oxidative, and anti-cancer activity, via inhibiting production of pro-inflammatory cytokines and enzymes or factors associated with carcinogenesis (e.g., matrix metalloproteinases, vascular endothelial growth factor), suggesting they may have therapeutic potential against IBD and CRC. However, their use is limited under both processing conditions or gastrointestinal interactions, reducing their stability and hence their bioaccessibility and bioavailability. Therefore, there is a need for more effective carriers that could be used for encapsulation of polyphenolic compounds. In recent years, natural polysaccharides have been proposed for creating carriers used in the synthesis of polyphenol encapsulates. Among these, hemicelluloses are particularly noteworthy, being characterized by good biocompatibility, biodegradation, low immunogenicity, and pro-health activity. They may also demonstrate synergy with the polyphenol payload. This review discusses the utility and potential of hemicellulose-based encapsulations of polyphenols as support for treatment of IBD and CRC.

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Hemicellulose-Based Delivery Systems: Focus on Pharmaceutical and Biomedical Applications

Patil

Pardeshi

Mahajan

et al. 2022

Clean Energy Production Technologies

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Xylan microparticles for controlled release of mesalamine: Production and physicochemical characterization

Cited by 15 publications

References 49 publications

Efficient fractionation of pure hemicellulose with high DP from bleached hardwood pulp using LiBr·3H₂O and co-production of dissolving pulp

Efficient fractionation of pure hemicellulose with high DP from bleached hardwood pulp using LiBr·3H₂O and co-production of dissolving pulp

Encapsulation of Polyphenolic Compounds Based on Hemicelluloses to Enhance Treatment of Inflammatory Bowel Diseases and Colorectal Cancer

Hemicellulose-Based Delivery Systems: Focus on Pharmaceutical and Biomedical Applications

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Xylan microparticles for controlled release of mesalamine: Production and physicochemical characterization

Cited by 15 publications

References 49 publications

Efficient fractionation of pure hemicellulose with high DP from bleached hardwood pulp using LiBr·3H2O and co-production of dissolving pulp

Efficient fractionation of pure hemicellulose with high DP from bleached hardwood pulp using LiBr·3H2O and co-production of dissolving pulp

Encapsulation of Polyphenolic Compounds Based on Hemicelluloses to Enhance Treatment of Inflammatory Bowel Diseases and Colorectal Cancer

Hemicellulose-Based Delivery Systems: Focus on Pharmaceutical and Biomedical Applications

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Product

Resources

About

Efficient fractionation of pure hemicellulose with high DP from bleached hardwood pulp using LiBr·3H₂O and co-production of dissolving pulp

Efficient fractionation of pure hemicellulose with high DP from bleached hardwood pulp using LiBr·3H₂O and co-production of dissolving pulp