XXY-trisomy identified by banding techniques in a male tortoiseshell cat

Hageltorn, M.; Gustavsson, I.

doi:10.1093/oxfordjournals.jhered.a109447

Cited by 5 publications

(3 citation statements)

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“…Gatos machos tortoiseshell ou cálico, normalmente são resultados de anomalias cromossômicas, dentre as quais se destacam a Síndrome de Klinefelter como a que ocorre na maioria dos casos, e resulta em um cariótipo 39, XXY; ocorre mais comumente por não disjunção meiótica (Hageltorn & Gustavsson, 1981;Hartwell et al, 2008;Leaman et al, 1999;Nicholas, 2010). O processo de não disjunção cromossômica se dá devido a uma falha que ocorre no momento em que os cromossomos homólogos, na meiose, ou as cromátides irmãs, na mitose, precisam se separar de forma apropriada para os polos opostos da célula (Costa et al, 2017).…”

Section: Anomalias Cromossômicas Envolvidas Na Pelagem De Gatos Domésticos Machos Tortoiseshell E Cálicounclassified

Genetic alterations involved in the expression of the coloring of tortoiseshell and calcial hair in domestic cats males: Review

Silva

Cabral

Rodrigues

et al. 2019

Pubvet

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Os mamíferos possuem conjunto cromossômico diploide, em que metade corresponde ao material genético herdado do pai, e a outra metade da mãe. Gatos domésticos (Felis catus) possuem número diploide de 38 cromossomos, sendo dois deles os cromossomos sexuais, responsáveis pela determinação do sexo, e que são representados por X e Y. As fêmeas possuem cromossomos sexuais XX, e os machos XY. As pelagens tortoiseshell e cálico podem estar presentes em gatos e são determinadas pela presença das cores preta e laranja em um mesmo animal, só que distribuídas de formas diferentes ao longo do corpo. Fisiologicamente, essas duas pelagens só podem ser observadas em fêmeas. Laranja e preto são cores determinadas pelo cromossomo X, portanto, conclui-se que essas duas cores só podem ser expressas em um mesmo animal, quando se trata de fêmeas, pois as mesmas possuem dois cromossomos X. Alguns machos nascem tortoiseshell ou cálico devido à ocorrência de anomalias cromossômicas, sendo a mais comum a anomalia semelhante à Síndrome de Klinefelter em humanos (47,XXY), que em gatos é 39,XXY. Essa condição é rara em machos, e para diagnóstico definitivo, o cariótipo é o exame citogenético mais utilizado. O trabalho teve por objetivo destacar as alterações genéticas envolvidas na presença das colorações das pelagens tortoiseshell e cálico em gatos domésticos machos, e o estudo tem importância na clínica veterinária de pequenos animais, já que essas desordens genéticas, em sua maioria, provocam distúrbios reprodutivos. A revisão tem significativa relevância na atuação do Médico Veterinário na área de citogenética clínica em pequenos animais, bem como no desenvolvimento de estudos voltados à área, que são consideravelmente escassos. Palavras chave: anomalia, cariótipo, citogenética, cromossomos Genetic alterations involved in the expression of the coloring of tortoiseshell and calcial hair in domestic cats males: Review

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Section: Anomalias Cromossômicas Envolvidas Na Pelagem De Gatos Domésticos Machos Tortoiseshell E Cálicounclassified

Genetic alterations involved in the expression of the coloring of tortoiseshell and calcial hair in domestic cats males: Review

Silva

Cabral

Rodrigues

et al. 2019

Pubvet

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“…It has been seen that genes on the X sex chromosome both in XX female and XY male cats have been shown to be regulators of coat color [12]. The chromosome separation failure which occurs in the gametogenesis process, so-called nondisjunction meiosis, introduces a type of tricolor male cats with XXY chromosome [13], [14], [15]. Before fertilization occurs, each cell will experience an event called gametogenesis, which is a biological process in which diploid or haploid precursor cells undergo cell division and differentiation to form adult haploid gametes.…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modeling and Sensitivity Analysis of the Existence of Male Calico Cats Population Based on Cross Breeding of All Coat Colour Types

Suandi

Ningrum

Alifah

et al. 2019

Communication in Biomathematical Sciences

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The coat color of cats is normally governed by genes found on the X chromosome in both male chromosome XY and female chromosome XX. The meiosis failure in the process of gametogenesis leads to the birth of three-colored male cats caused by an excess of the X chromosome in the male chromosome type XY. The chromosome structure of three-color male cats, called male calico cats, appeared similar to the XXY Klinefelter's syndrome in human. Mathematical modeling and investigation of the factors that influence the infrequency of male calico cats are our main objectives of this paper. In addition, we also discuss the possible contributions and strategies to overcome the scarcity of these cats. We construct a mathematical model based on a combination of genes in the chromosome that regulates the color of cat coat on the fertilization process. The mathematical model is given as a six-dimensional system of differential equations. Sensitivity analysis is used to investigate the important parameters in the existence of male calico cats. Our finding states that the probability of normal male cats meiosis is a crucial parameter in the maintenance of the existence of male calico cats. Furthermore, one of the strategies that we could recommend in maintaining the existence of male calico cats is minimizing the value of the successful meiosis probability of normal male cats.

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“…The XXY condition has been reported for man (Klinefelter syndrome: Ferguson-Smith et al, I960 ;Hamerton et al, 1975; Abyholm and Stray-Pedersen, 1981) and many species of mammal: tamar wallaby (Sharman et al, 1970), common shrew (Searle, 1984), mouse (Cattanach, 1961), black rat (Yosida, 1979), Chinese hamster (Ivett et al, 1978), wood lemming (Gropp et al, 1976), pig (Breeuwsma, 1968;Hancock and Baker, 1981), bull (Scott and Gregory, 1965), sheep (Bruere et al, 1969), goat (Bhatia and Shanker, 1992), horse (Kubien et al, 1993), cat (Centerwall and Benirschke, 1975;Hageltorn and Gustavsson, 1981) and dog (Clough et al, 1970). In all these species, the XXY condition results in a male phenotype with small testes that lack germ cells (Cattanach, 1974).…”

Section: Introductionmentioning

confidence: 99%

An XXY sex chromosome constitution in a house musk shrew (Suncus murinus L.) with testicular hypoplasia

Mb¹,

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Ai³

et al. 1998

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XXY-trisomy identified by banding techniques in a male tortoiseshell cat

Cited by 5 publications

References 0 publications

Genetic alterations involved in the expression of the coloring of tortoiseshell and calcial hair in domestic cats males: Review

Genetic alterations involved in the expression of the coloring of tortoiseshell and calcial hair in domestic cats males: Review

Mathematical Modeling and Sensitivity Analysis of the Existence of Male Calico Cats Population Based on Cross Breeding of All Coat Colour Types

An XXY sex chromosome constitution in a house musk shrew (Suncus murinus L.) with testicular hypoplasia

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