Xuebijing injection and its bioactive components alleviate nephrotic syndrome by inhibiting podocyte inflammatory injury

Yuan, Shengliang; Cao, Yiwen; Jiang, Jiaying; Chen, Junqi; Huang, Xiuye; Li, Xiaojie; Zhou, Jie; Zhou, Yuan; Zhou, Jiuyao

doi:10.1016/j.ejps.2024.106759

European Journal of Pharmaceutical Sciences

2024

DOI: 10.1016/j.ejps.2024.106759

|View full text |Cite

Xuebijing injection and its bioactive components alleviate nephrotic syndrome by inhibiting podocyte inflammatory injury

Shengliang Yuan,

Yiwen Cao,

Jiaying Jiang

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Investigation of bioactive components and metabolic pathways of Zhen‐wu‐tang in rat plasma and renal tissue by UPLC‐Q‐TOF/MS

Yuan,

Chen,

Cao

et al. 2024

Phytochemical Analysis

View full text Add to dashboard Cite

IntroductionZhen‐wu‐tang (ZWT) is a traditional Chinese medicine (TCM) formula for the treatment of several kidney diseases. However, due to the complexity of the TCM formula, there is a lack of accurate knowledge of the chemical constituents of ZWT and its bioactive components, as well as in vivo metabolic pathway studies.ObjectivesThe chemical composition of ZWT and its bioactive components along with the metabolic pathways were investigated by a combination of chemical profiling and serum pharmacochemistry.MethodsHigh‐resolution ultra‐performance liquid chromatography‐quadrupole time‐of‐flight mass spectrometry was used to identify the chemical components of ZWT and its bioactive components and metabolites in vivo.ResultsAs a result, a total of 110 chemical components were identified from ZWT solution, mainly amino acids, alkaloids, gingerols, monoterpene glycosides and terpenoids, and so on. In addition, 24 prototype components and 36 metabolites were detected in rat plasma. Meanwhile, 8 prototype components were detected in rat kidney tissue but no metabolites. Interestingly, 4 of the 28 bioactive components were detected in both plasma and renal tissue, which were atractylenolide III, trimethoxyaconitane, methyl gallate, and paeoniflorin. The metabolic pathways mainly involved Phases I and/or II metabolic reactions such as hydrolysis, oxidation, reduction and hydration, methylation/demethylation, sulphation, glucuronidation, acetylation, and glutathione conjugation.ConclusionOverall, the present study has comprehensively elucidated the chemical composition of ZWT and its potential bioactive components and metabolites, which provides a basis for the basic study of its pharmacodynamic substances and a reference for the study of the bioactive components of TCM formulae.

show abstract

Investigation of bioactive components and metabolic pathways of Zhen‐wu‐tang in rat plasma and renal tissue by UPLC‐Q‐TOF/MS

Yuan,

Chen,

Cao

et al. 2024

Phytochemical Analysis

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Xuebijing injection and its bioactive components alleviate nephrotic syndrome by inhibiting podocyte inflammatory injury

Cited by 1 publication

References 26 publications

Investigation of bioactive components and metabolic pathways of Zhen‐wu‐tang in rat plasma and renal tissue by UPLC‐Q‐TOF/MS

Investigation of bioactive components and metabolic pathways of Zhen‐wu‐tang in rat plasma and renal tissue by UPLC‐Q‐TOF/MS

Contact Info

Product

Resources

About