“…Nonetheless, but just as clearly, the paper reprinted in this issue of The Journal and the 2 related manuscripts had an important impact on the field as recognized by Henry Christian as early as 1917 (33). By 1925 one of the most important aspects of Osler’s reports, including the one reprinted in this issue, was appreciated (34). Namely, Osler viewed skin disease, particularly purpuric skin disease, as only a symptom of underlying systemic illness in the ‘erythema group’ illnesses, a concept first advanced by him.…”