Xii.—skin Reactions to Apothesin and Quinin in Susceptible Persons

Identification of Risk Factors and Cross-Reactivity of Local Anesthetics Hypersensitivity: Analysis of 14-Years’ Experience

“…3 Although the first allergic reaction was reported as back as 1920, a contact dermatitis caused by an ester-type local anesthetic agent, the vast majority of the ADRs are nonimmunologic reactions like toxicity, intravascular administration of LA, overdosage of LA, anxiety (needle phobia, panic attacks, vasovagal syncope) and the pharmacological effect of added vasopressors (eg adrenaline). 4 , 5 Hypersensitivity reactions are rare and thought to represent less than 1% of all ADRs. Allergic reactions to LAs can manifest as immediate IgE mediated (type I) and/or non-immediate T-cell mediated (type IV).…”

Allergies to local anesthetics — the real truth

“…Mook 4 described one case of eczematous contact dermatitis on a dentist's hand following the handling of apothesin, which was an amino-ester congener of procaine. Subsequent skin testing clearly linked apothesin with the dermatitis and the lesions cleared up once the offending agent was removed.…”

Allergy to local anesthetics: Reality or myth?

“…Monk reported the case of a dentist who developed contact dermatitis after chronic application of apothesin, an ester local anesthetic [2]. Several other cases of contact dermatitis were subsequently published, but few patients developed anaphylaxis [3].…”