Xanthomatous infiltration of ankle tendons

Kelman, Chad G.; Disler, David G.; Kremer, Joel M.; Jennings, Timothy A.

doi:10.1007/s002560050231

Cited by 16 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, tophi may contain calcifications and the distinction of tophi from other calcified lesions may be difficult. CT is useful in differentiating tophi from other soft tissue masses such as xanthomas [16] or rheumatoid nodules [17], which have a lower attenuation than tophi.…”

Section: Computed Tomographymentioning

confidence: 99%

The advanced imaging of gouty tophi

Gentili

2006

Curr Rheumatol Rep

View full text Add to dashboard Cite

Gout is a metabolic disorder in which there is hyperuricemia caused by an increase in production or a decrease in excretion of uric acid. Long-lasting hyperuricemia causes the deposition of monosodium urate crystals in the joints and soft tissues, triggering gouty arthritis and, if not properly treated, the formation of gouty tophi. The diagnosis of gout is usually based on clinical presentation and laboratory examinations, long before any abnormality can be demonstrated with imaging. Radiography is the primary imaging modality used in the initial evaluation of gouty arthritis. Ultrasonography, CT, MRI, and nuclear medicine are seldom necessary. Occasionally a tophus has an unusual presentation and simulates neoplasm or infection prompting the utilization of cross-sectional imaging for further evaluation and surgical planning. Cross-sectional imaging is also used in areas that are difficult to visualize on radiographs such as spine, sacroiliac joints, and soft tissues.

show abstract

Section: Computed Tomographymentioning

confidence: 99%

The advanced imaging of gouty tophi

Gentili

2006

Curr Rheumatol Rep

View full text Add to dashboard Cite

show abstract

“…Upon further history, the patient had been misdiagnosed with rheumatoid arthritis and gout previously. Imaging and histopathology in that case confirmed xanthomatous involvement of nearly all the ankle tendons, in addition to the tuberous xanthomas [5].…”

Section: Discussionmentioning

confidence: 86%

“…After a search of the English literature, we are aware of only four studies focusing on the imaging characteristics in patients with multifocal manifestations of tendon and/or tuberous xanthomas [3][4][5][6]. Emphasizing family screening in the primary care setting, one study performed a sonographic examination of several family members diagnosed with heterozygous familial hypercholesterolemia manifesting with xanthomas of the Achilles tendons as well as cutaneous deposits at the elbows and knees [6].…”

Section: Discussionmentioning

confidence: 99%

“…We present an exceptional case of extensive xanthomatous involvement of the tendons of the appendicular skeleton and several deposits within the integumentary system in a patient with familial hyperlipidemia. Although many clinical reports regarding multifocal xanthomas have been described, only a few studies to date have focused on the radiologic, MR, and sonographic imaging findings [3][4][5][6]. We present imaging descriptions of an extensive case of xanthomatous involvement, thereby providing additional insight and recognition of the imaging characteristics of this potentially multifocal, systemic disease.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

An exceptional case of xanthomatous infiltration of the musculoskeletal and integumentary systems

et al. 2015

View full text Add to dashboard Cite

Tendinous and subcutaneous xanthomas are most commonly associated with primary hyperlipidemia. Xanthomatosis caused by cholesterol deposition can be a high risk marker for cardiovascular disease related to premature atherosclerosis; thus, early recognition of this diagnosis may reduce mortality and morbidity. Achilles tendon involvement is most common, followed by the extensor tendons of the hand and elbow. We present an exceptional case of tendinous and tuberous xanthomas, with intraoperative and histologic correlation, in a 34-year-old female manifesting with xanthomatous deposits of nearly all ankle tendons, plantar aponeurosis, extensor tendons of the hands, and various locations within the integumentum. To the authors' knowledge, only four studies to date have focused specifically on imaging findings of multifocal xanthomas. Thus, the radiographic and MR imaging descriptions of xanthomas in this report further add to the existing literature by helping to identify imaging characteristics of this multifocal systemic disease. The diagnosis of this condition should alert the physician to the presence of a dyslipidemia that can be treated with dietary modifications and/or drug therapy.

show abstract

“…These characteristic of low-signal trabeculations represent areas of residual normal collagen fascicles; the globular areas of mixed signal intensity represent the xanthomatous deposits (9). Not only bilateral Achilles tendons, but also other multifocal tendons were involved in our case.…”

mentioning

confidence: 73%