2014
DOI: 10.1155/2014/636491
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Abstract: Leptospiral immunoglobulin-like (Lig) proteins are of great interest due to their ability to act as mediators of pathogenesis, serodiagnostic antigens, and immunogens. Purified recombinant LigA protein is the most promising subunit vaccine candidate against leptospirosis reported to date, however, as purified proteins are weak immunogens the use of a potent adjuvant is essential for the success of LigA as a subunit vaccine. In the present study, we compared xanthan pv. pruni (strain 106), aluminium hydroxide (… Show more

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Cited by 23 publications
(29 citation statements)
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“…In terms of protection, LigA is probably the best vaccine candidate identified to date, reviewed in [11]. However, sub-lethal levels of infection were detected in the majority of surviving animals, regardless of the delivery route or the adjuvant used [21, 22, 25, 36, 38, 39]. Furthermore, LigA is not conserved amongst all pathogenic Leptospira spp., it has been identified in only three pathogenic species to date [31], while LigB has been found in all pathogenic Leptospira spp.…”
Section: Discussionmentioning
confidence: 99%
“…In terms of protection, LigA is probably the best vaccine candidate identified to date, reviewed in [11]. However, sub-lethal levels of infection were detected in the majority of surviving animals, regardless of the delivery route or the adjuvant used [21, 22, 25, 36, 38, 39]. Furthermore, LigA is not conserved amongst all pathogenic Leptospira spp., it has been identified in only three pathogenic species to date [31], while LigB has been found in all pathogenic Leptospira spp.…”
Section: Discussionmentioning
confidence: 99%
“…Several leptospiral recombinant proteins have been reported to confer an at least partial protective effect in immunized animals. [13][14][15][16][17][18][19] Different strategies and adjuvants have been employed with the aim of obtaining protective immunity accompanied by renal clearance, [20][21][22][23][24][25][26][27][28][29][30] but to date, only a few proteins have been shown to be promising protective antigens, depending on the strategy and adjuvants employed. Based on these data, the administration of a multi-epitope fusion protein appears to be an attractive strategy to provide animal survival and avoid renal carriage.…”
Section: Introductionmentioning
confidence: 99%
“…As a subunit vaccine, LigANI has been previously evaluated with Freund’s complete adjuvant (Silva et al 2007, Coutinho et al 2011), aluminium hydroxide (Palaniappan et al 2006, Hartwig et al 2014), xanthan (Bacelo et al 2014), poly (lactide-co-glycolic acid), and liposomes (Faisal et al 2009) as adjuvants, but not with inorganic nanomaterials.…”
mentioning
confidence: 99%
“…Two independent experiments were performed. The recombinant protein dose used for immunisation was 50 µg, which was able to induce protective immunity in another study developed by our group (Bacelo et al 2014). The hamsters were immunised subcutaneously on day 0 and boosted on day 14.…”
mentioning
confidence: 99%