X.—precancerous Lesions of the Skin of the Vulva

Taussig, Fred J.

doi:10.1001/archderm.1920.02350060002001

Cited by 9 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Anhand des vorliegenden Falles möchten wir die in der Literatur angegebenen Häufigkeiten der Entstehung eines Stachelzellkarzinoms bei Lichen sclerosus der Frau besprechen. Taussig beschreibt in einer Reihe von Artikeln zwischen 1920 und 1940 erstmals eine Korrelation von Lichen sclerosus und Malignität [16, 17, 18, 19]. Hier zeigten 73 % aller, aufgrund von Malignität durchgeführten Vulvektomien ein gleichzeitiges Vorhandensein von „Leukoplakie”.…”

Section: Besprechungunclassified

Lichen sclerosus und Vulvakarzinom

Hagedorn

Golüke

Mall

2003

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Genital lichen sclerosus in women is a clinically and histologically well defined disease. In addition to the classical atrophic form, there is a hypertrophic variant, which is characterised histologically by squamous cell hyperplasia. The aetiology is unknown but an autoimmune pathogenesis seems most likely. Infectious or hormonal influences do not play a major role. We describe a squamous cell carcinoma of the vulva with a co-existing lichen sclerosus. This case raises again the question of a precancerous potential of lichen sclerosus. In the dermatological literature, only a few cases with association of lichen sclerosus and squamous cell carcinoma are known. This is in contrast to gynaecological literature, where a high number of squamous cell carcinomas has been described. Gynaecologists search for the histological findings of lichen sclerosus adjacent to squamous cell carcinoma. Such an attempt is not valid without the clinical signs of lichen sclerosus, so that indeed classical lichen sclerosus does not seem to be a precancerous lesion. On the other hand, the hypertrophic form of lichen sclerosus seems to be associated with squamous cell carcinoma in about 3-5% of case.

show abstract

Section: Besprechungunclassified