2018
DOI: 10.1101/291450
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Abstract: 16Sex is an increasingly important feature of mouse naive pluripotent stem cells (PSCs)

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Cited by 14 publications
(33 citation statements)
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References 69 publications
(157 reference statements)
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“…Multiple studies have also shown that the double dose of X-linked genes due to XCR in XX iPSCs has consequences for the molecular and cellular properties of iPSCs [ 51 , 154 , 155 ], in line with previous work in ESCs [ 156 , 157 , 158 ]. XX PSCs acquire global and sex-specific DNA hypomethylation and open chromatin landscapes [ 51 , 155 , 158 ].…”
Section: Xcr During Cellular Reprogramming In Micesupporting
confidence: 66%
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“…Multiple studies have also shown that the double dose of X-linked genes due to XCR in XX iPSCs has consequences for the molecular and cellular properties of iPSCs [ 51 , 154 , 155 ], in line with previous work in ESCs [ 156 , 157 , 158 ]. XX PSCs acquire global and sex-specific DNA hypomethylation and open chromatin landscapes [ 51 , 155 , 158 ].…”
Section: Xcr During Cellular Reprogramming In Micesupporting
confidence: 66%
“…In the initiation phase of XCR, reprogramming induces reacquisition of PRC2 enrichment on the Xi [ 25 ]. The progression phase induces reactivation of endogenous pluripotency genes [ 23 , 25 , 42 , 48 , 49 ] and include, Tsix reactivation [ 23 , 25 , 42 ], Xist silencing [ 23 , 25 , 42 ], loss of PRC2, H3K27me3 and macroH2A enrichment on the Xi [ 23 , 25 , 42 ], as well as gain of histone acetylation and active RNA Polymerase II [ 25 , 42 , 48 ], DNA demethylation [ 25 , 42 , 51 ], and transcriptional reactivation [ 23 , 25 , 42 , 48 , 49 , 150 , 154 ]. In the completion phase, stable and heritable gene silencing is reversed and the X chromosome reacquires the ability to undergo random XCI upon differentiation [ 42 ].…”
Section: Xcr During Cellular Reprogramming In Micementioning
confidence: 99%
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“…These sex differences have been investigated at the molecular level in female mouse embryonic stem cells (mESC), which are derived from early blastocyst embryos and thus carry two active X chromosomes. Female mESCs appear to be shifted towards a more naive ground state of pluripotency, which is associated with reduced activity of the differentiation-promoting MAP kinase (MAPK) signalling pathway, increased levels of (naive) pluripotency factors and lower levels of global DNA methylation (Schulz et al 2014;Song et al 2019;Zvetkova et al 2005) . As a consequence, exit from the pluripotent state during differentiation is delayed in female compared to male mESCs (Schulz et al 2014) .…”
Section: Introductionmentioning
confidence: 99%