WWP1 localizes in the Golgi apparatus and contributes to maintaining glycosaminoglycan synthesis in adipocytes
Yuka Nozaki,
Fumika Suwa,
Kazuhiro Furuya
et al.
Abstract:White adipocytes are a major component of white adipose tissue (WAT) and help to maintain systemic metabolic homeostasis because they store energy and secrete adipokines. In mice deficient in the protein WWP1 (WW domain-containing E3 ubiquitin protein ligase 1) oxidative stress in adipocytes is increased but insulin resistance induced by obesity is improved. However, the specific roles of WWP1 in adipocytes remain unclear. Here, we show that in 3T3L1 adipocytes WWP1 is localized in the Golgi apparatus and can … Show more
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