Wound Healing Dressing System for Diabetic Wounds Based on Curcumin and Syringic Acid

Abstract

Background: This work is based on the development of a wound healing dressing system for diabetic wounds using curcumin and syringic acid. A diabetic wound differs from a normal wound in respect to many pathophysiological changes. Therefore multiple issues like hemostasis, inflammation, cell proliferation and tissue remodeling need to be considered while selecting actives. A combination of curcumin, syringic acid and Aloe vera can address such aspects of pathophysiological changes in diabetic wound healing. Materials and Methods: Initially curcumin and syringic acid were mixed with Aloe vera juice. Carbopol 934 was used as a gelling agent for this mixture. This gel was loaded into sterilized polyurethane foam. The prepared dressing system was evaluated for in vitro and in vivo performance. Results: The dressing system showed excellent folding endurance. Ex vivo antibacterial activity was found to be excellent against Staphylococcus aureus and Escherichia coli. The zone of inhibition of developed foam dressing was found 25 ± 5 mm for Staphylococcus aureus and 20 ± 3 mm for Escherichia coli. In vitro diffusion was found to be 88.40% and 84.65 % for curcumin and syringic acid respectively. Diabetes induced rats were used for evaluating in vivo wound healing activity and complete wound healing was observed at the end of 14 days. Conclusion: Polyurethane foam dressing system based on curcumin, syringic acid and Aloe vera can show promising wound healing in diabetes conditions.