2015
DOI: 10.18632/aging.100726
View full text | Cite
Has erratum 2016-2-28
|
Sign up to set email alerts
|

Abstract: Does the longevity phenotype offer an advantage in wound healing (WH)? In an attempt to answer this question, we explored skin wound healing in the long-lived transgenic αMUPA mice, a unique model of genetically extended life span. These mice spontaneously eat less, preserve their body mass, are more resistant to spontaneous and induced tumorigenesis and live longer, thus greatly mimicking the effects of caloric restriction (CR). We found that αMUPA mice showed a much slower age-related decline in the rate of … Show more

Help me understand this report
Editorial notices

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
7
0

Year Published

2015
2015
2016
2016

Publication Types

Select...
3

Relationship

2
1

Authors

Journals

citations
Cited by 13 publications
(9 citation statements)
references
References 38 publications
(53 reference statements)
2
7
0
Order By: Relevance
“…Gene expression during wound healing As expected (for example, see Grose and Werner 2003;Yanai et al 2015), for all groups examined, we consistently observed an overexpression of genes related to the extracellular matrix (ECM) including ECM organization, ECM-receptor interaction, collagen metabolism, and focal adhesion (Online Resource 5). Accordingly, the combined score which reflects both the fold enrichment and the statistical significance, was the highest for these categories in all groups and time points (Online Resource 5).…”
Section: Age-related Differences In Gene Expression Of Intact Skinsupporting
confidence: 75%
“…Likewise, castration of male mice extends their life span and improves wound repair. In our previous study on female FVB/N mice (Yanai et al 2015), we found clear differences in the rate of head skin wound closure and gene expression between young and old females. It would be interesting to examine if our observations are relevant for middle-aged C57BL/6 female mice as well.…”
Section: Discussionmentioning
confidence: 70%
“…Moreover, it seems that the association between the rate of WH and longevity is primarily attributed to an overall effect of the target gene on organismal aging rather than to its skin-specific action. This assumption is strongly exemplified by our study on the long-lived αMUPA mice, which preserve their skin WH capacity up to an old age (at least 25 months) [10, 27]. In this unique model [28], the uPa transgene is expressed in the ocular lens and the brain stem but not in the skin, thus excluding the gene-specific effects on WH.…”
Section: Resultsmentioning
confidence: 94%
“…26 For example, in old aMUPA mice the apoptosis are regulated after full wound closure and none is differentially expressed in the intact skin, whereas the WT mice exhibited significant age-related differences in gene expression of apoptosis both in intact animals and in the course of skin wound healing. 27 Construction of association networks should help to identify crucial components of the pathophysiology. During construction of such networks by means of topological analysis, we detected central or most important nodes: the genes that probably play essential roles in the relevant biological systems.…”
Section: Discussionmentioning
confidence: 99%
“…29 Suppression of the system of repair of single-strand and double-strand breaks in DNA is characteristic of many neurodegenerative diseases including AMD 30 and Alzheimer disease. 27,31 , There is evidence that mice with the defective NHEJ pathway undergo accelerated senescence. 32 It is also known that mutations in the Lig4 gene are a cause of severe immunodeficiency.…”
Section: Discussionmentioning
confidence: 99%