Wound healing activity of the aqueous extract of Thespesia populnea fruit

Nagappa, Anantha Naik; Cheriyan, Binu

doi:10.1016/s0367-326x(01)00275-1

Cited by 47 publications

(29 citation statements)

References 2 publications

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“…T.populnea has number of medicinal properties [19][20][21][22] and many reports are available regarding its role in different pharmacological activities [23][24][25] . Different parts of the plant are effective in some activities [26][27][28][29] but there are fewer reports on seeds of T.populnea.…”

Section: Discussionmentioning

confidence: 99%

Studies on Phytochemical Constituents, Quantification of Total Phenolic, Alkaloid Content and In-vitro Anti-oxidant Activity of Thespesia populnea Seeds

Rao

et al. 2011

Free Radicals and Antioxidants

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Introduction: Anti-oxidants are vital substances which possess the ability to protect the body from damage caused by free radical induced oxidative stress. There is an increasing interest in natural anti-oxidants, e.g., polyphenols, present in medicinal and dietary plants, which might help prevent oxidative damage. Methods: In this present study we investigated preliminary phytochemical, total phenolic, alkaloid content and In-vitro antioxidant activity of hexane, ethyl acetate, ethanol (70%) and methanol extracts of Thespesia populnea Seeds. Results: Thespesia populnea Seeds revealed the presence of steroids, flavonoids and alkaloids, glycosides, tannins, quinones and carbohydrates. The extracts do not contain the amino acids, oils and the hexane fraction do not contain triterpenes and tannins. The ethyl acetate extract have more phenolic content than other extracts and the methanolic extract has more alkaloidal than other extracts. The selected plant extracts were produced concentration dependent percentage inhibition of superoxide radical and produced maximum activity at a concentration of 160 µg and there after the percentage inhibition were raised gradually to its maximum level with higher concentrations. Conclusion: Among the four types of T.populnea seeds extracts, the methanolic extract showed better activity than aqueous extracts at 160 µg concentrations.

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Section: Discussionmentioning

confidence: 99%

Studies on Phytochemical Constituents, Quantification of Total Phenolic, Alkaloid Content and In-vitro Anti-oxidant Activity of Thespesia populnea Seeds

Rao

et al. 2011

Free Radicals and Antioxidants

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“…The number and the area of wounds that can be made depend on the animal's size and the part of the body. The smallest wounds, on the order of several-mm punches, can be made in mouse embryos 57 , round wounds up to 2 cm in diameter are possible in rats 58 , and in pigs wounds with areas of tens of square centimetres can be studied 59 . The biggest free surface is the dorsum, which is also difficult for an animal to reach, and that is why (54) 658 (54) 289 (54) 4700-7500 (55) * In mm ** The value for rabbit hypodermis was determined from values for whole skin and other layers (this information was not found in the literature).…”

Section: In Vivo Assaysmentioning

confidence: 99%

Models for the study of skin wound healing. The role of Nrf2 and NF-κB

Ambrožová¹,

Ulrichová²,

Galandáková³

2017

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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a,bNrf2 and NF-κB transcription factors act in wound healing via their anti-inflammatory and anti-oxidant effects or through the immune response. Studying this process is a matter of some importance given the high cost of wound treatment. A major contribution in this regard is being made by models that enable investigation of the involvement of multiple factors in wound healing and testing new curative substances. This literature review was carried out via searches in the PubMed and Web of Science databases up to 2016. It covers skin wound healing, available models for its study (part I), the role of Nrf2 and NF-κB, substances that influence them and whether they can be used as markers (part II). Was found that in vitro assays are used for their availability but a holistic view must be established in vivo. In silico approaches are facilitating assessment of a vast amount of research data. Nfr2 and NF-κB play a crucial and reciprocal role in wound healing. Nrf2 controls repair-associated inflammation and protects against excessive accumulation of ROS while Nf-κB activates the innate immune reaction, proliferation and migration of cells, modulates expression of matrix metalloproteinases, secretion and stability of cytokines and growth factors for wound healing.

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“…There are several reports stating that the extracts of various plants are used for wound healing properties. [4,[7][8][9][10][11][12][13][14] Hydrolea zeylanica (L.) Vahl. family Hydrophyllaceae is found throughout India in moist and swampy places.…”

Section: Original Articlementioning

confidence: 99%

Untitled

Qureshi

2017

IJGP

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Background: Hydrolea zeylanica L. leaves are used traditionally for burns, wounds, antiseptic, and callus ulcers. Objective: The objective of the study was to discuss chemical composition and to evaluate the wound healing property of H. zeylanica L. methanol extract (HZLME) on rats using excision and incision wound models. Materials and Methods: Wistar albino rats (150-200 g) were divided into four groups (n = 6). Group I negative control (Water-soluble ointment base), Group II standard (povidone iodine [5% w/w] ointment), Group III Test I -HZLME ointment (5% w/w), and Groups IV Test II -H. zeylanica leaf aqueous extract ointment (5% w/w) were applied topically. In incision wound models, the treatment was given for 10 days from the day of wound; skin breaking strength was estimated in incision wound model. In excision wound model, treatment continued until wound is completely healed. Rate of wound contraction and period of epithelization was evaluated thereafter. The data were analyzed by oneway ANOVA, followed by Dunnett's test. Results: Gas chromatography-mass spectrometry chromatogram analysis of the HZLME showed several peaks indicating the presence of various phytochemical constituents. HZLME increased the rate of wound contraction, decreased the period of epithelization and increased skin breaking strength. Conclusion: The use of H. zeylanica in various skin diseases has been proved by this work, as it showed a wound healing potential.

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Wound healing activity of the aqueous extract of Thespesia populnea fruit

Cited by 47 publications

References 2 publications

Studies on Phytochemical Constituents, Quantification of Total Phenolic, Alkaloid Content and In-vitro Anti-oxidant Activity of Thespesia populnea Seeds

Studies on Phytochemical Constituents, Quantification of Total Phenolic, Alkaloid Content and In-vitro Anti-oxidant Activity of Thespesia populnea Seeds

Models for the study of skin wound healing. The role of Nrf2 and NF-κB

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