Wound cleansing: benefits of hypochlorous acid

Dissemond, Joachim

doi:10.12968/jowc.2020.29.sup10a.s4

“…The resulting HOCl contributes to the bactericidal activity of neutrophils and is thought to cause tissue damage in areas of inflammation. In many studies, it has been stated that the use of HOCl has positive effects on wound healing [ 53 ]. In an in-vitro study, the effectiveness of NaClO/HClO solutions on wound healing was investigated and an increased antimicrobial effect was associated with decreased viability of keratinocytes and fibroblasts.…”

Section: Discussionmentioning

confidence: 99%

Comparison of hyaluronic acid, hypochlorous acid, and flurbiprofen on postoperative morbidity in palatal donor area: a randomized controlled clinical trial

Alpan

¹

,

Cin

²

2023

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Objective This study aims to evaluate the effects of topical hyaluronic acid (HA), hypochlorous acid (HOCl), and flurbiprofen on postoperative morbidity of palatal donor sites after free gingival graft (FGG) surgery. Materials and methods Sixty patients requiring FGG were randomly assigned into four groups: control, HA gel (600 mg/100 g high molecular weight hyaluronic acid), HOCl spray (170–200 ppm, ph7.1), flurbiprofen spray (0.075gr flurbiprofen). Topical agents were applied for 14 days, according to groups. Patients were followed for 28 days. Palatal healing was assessed with the Laundry wound healing index (WHI). Complete epithelization (CE) was evaluated with photographs and H 2 O 2 bubbling. Pain, burning sensation, chewing efficacy, and tissue color match (CM) were evaluated using a visual analog scale (VAS). Postoperative analgesic consumption and delayed bleeding (DB) were also recorded. Results HA provided better WHI values on the 7 th , 14 th , and 21 st days compared to the other groups, respectively ( p < 0.05). CE was formed on the 21 st day in the HA group but on the 28 th day in the other groups. HOCl and flurbiprofen groups were not different from the control group or each other in terms of WHI. HOCl had the lowest VAS scores of all time periods. DB was not observed in any group. Significantly fewer analgesics were taken in the topical agent-applied groups compared to the control group . Conclusions HA exhibits a positive impact on the epithelization of palatal wound healing and color matching. HOCl and flurbiprofen provided less pain; however, they might have negative effects on palatal wound healing. Clinical relevance As a result of obtaining free gingival grafts from palatal tissue for mucogingival surgical procedures, secondary wound healing of the donor area occurs. This wound in the palatal region can cause discomfort and pain every time patients use their mouths. The use of HA can reduce postoperative complications by accelerating wound healing and reducing pain. The topical use of flurbiprofen and HOCl can reduce patients’ pain.

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“…HOCl acts as secondary reactive oxygen species when produced endogenously and this is the way it carries out its mechanism of action. Due to its own endogenous nature, HOCl possesses an inherently good safety profile as demonstrated in numerous international studies [32][33][34][35] .…”

Section: Potential Benefit Of Hocl On the Face And Skinmentioning

confidence: 99%

A Potential Benefit of Hypochlorous Acid - Facial Sanitisation

Nowbuth¹,

Armstrong²,

Cloete³

et al. 2021

Preprint

0

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Sanitisation has become a major component of everyday life, with emphasis on the hands and surfaces. The face remains unsanitised due to the lack of an acceptable sanitiser. The use of masks has been mandated to reduce the spread of the pathogens by covering the face, however, there remain issues with the use of personal protective equipment. The face remains a harbour for upper respiratory tract infections, with constant deposition of microbes. By reducing microbial load, the risk of both infection and severity are reduced. HOCl has proven antimicrobial and anti-inflammatory activity, including efficacy against SARS-CoV-2. A facial sanitiser, alongside hand sanitisers and masks, improves protection against SARS-CoV-2. The advantages of regular sanitising of the face and mask include reduced level of microbial contamination, risk of biofilm formation, and respiratory tract and skin infections. HOCl was reviewed as a face and mask sanitiser, concluding that it was an ideal product.

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“…Due to the efficacy and safety of HOCl, it is proposed for facial sanitisation, as well as sanitisation of nasal and oral cavities. Due to its own endogenous nature, HOCl is inherently safe, as demonstrated in numerous international studies [24][25][26][27][28][29] .…”

Section: Potential Benefit Of Hocl On the Face And Skinmentioning

confidence: 99%

A Potential Benefit of Hypochlorous Acid - Facial Sanitisation

Nowbuth¹,

Armstrong²,

Cloete³

et al. 2021

Preprint

0

View full text Add to dashboard Cite

Sanitisation has become a major component of everyday life, with emphasis on the hands and surfaces. The face remains unsanitised due to the lack of an acceptable sanitiser. The use of masks has been mandated to reduce the spread of the pathogens by covering the face, however, there remain issues with the use of personal protective equipment. The face remains a harbour for upper respiratory tract infections, with constant deposition of microbes. By reducing microbial load, the risk of both infection and severity are reduced. HOCl has proven antimicrobial and anti-inflammatory activity, including efficacy against SARS-CoV-2. A facial sanitiser, alongside hand sanitisers and masks, improves protection against SARS-CoV-2. The advantages of regular sanitising of the face and mask include reduced level of microbial contamination, risk of biofilm formation, and respiratory tract and skin infections. HOCl was reviewed as a face and mask sanitiser, concluding that it was an ideal product.

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Wound cleansing: benefits of hypochlorous acid

Abstract: Cleansing provides an opportunity to remove pathogens from the wound bed, thereby preventing an increase in the bioburden and delayed healing. This article describes the reported efficacy of hypochlorous acid-containing wound cleansers

Cited by 13 publications

References 22 publications

Comparison of hyaluronic acid, hypochlorous acid, and flurbiprofen on postoperative morbidity in palatal donor area: a randomized controlled clinical trial

Comparison of hyaluronic acid, hypochlorous acid, and flurbiprofen on postoperative morbidity in palatal donor area: a randomized controlled clinical trial

A Potential Benefit of Hypochlorous Acid - Facial Sanitisation

A Potential Benefit of Hypochlorous Acid - Facial Sanitisation

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