Would you have an injection without knowing its formula? New challenges in platelet-rich plasma therapy

Fermín, Theodorakys Marín; Scarlat, Marius M.; Laupheimer, Markus Wilhelm

doi:10.1007/s00264-022-05566-z

Cited by 9 publications

(4 citation statements)

References 12 publications

(9 reference statements)

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“…These inconsistencies in the reporting of orthobiologics interventions have been exposed by several authors, as has been the number of injections and presence of leukocyte cells in PRP preparations. 29 - 31 Using adipose-derived expanded MSC studies showed a dose-dependent effect of PRP and ASCs. 32 Bansal et al , 33 in a recent randomized controlled trial, found a cut-off dose of 10 billion platelets for sustained effects on knee OA, with significant IKDC and WOMAC score improvement at 1-year follow-up.…”

Section: Discussionmentioning

confidence: 99%

Knee Osteoarthritis: Clinical and MRI Outcomes After Multiple Intra-Articular Injections With Expanded Autologous Adipose-Derived Stromal Cells or Platelet-Rich Plasma

Khoury,

Chamari,

Tabben

et al. 2023

CARTILAGE

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Objective To directly compare clinical and MRI outcomes of multiple intra-articular injections of adipose-derived stromal cells (ASCs) or platelet-rich plasma (PRP) in patients with knee osteoarthritis (OA). Design We retrospectively compared 24-month outcomes in (1) 27 patients receiving 3-monthly intra-articular injections with a total of 43.8 million ASCs and (2) 23 patients receiving 3-monthly injections of 3-ml preparation of PRP. All patients had Kellgren-Lawrence grade 1, 2, or 3 knee OA with failed conservative medical therapy. The Numeric Pain Rating Scale (NPRS) scores; Knee injury and Osteoarthritis Outcome Score (KOOS) at baseline, 6, 12, and 24 months after the first injection; and the MRI Osteoarthritis Knee Score (MOAKS) at 12 and 24 months were considered as outcomes. Results No major complications occurred in any patient. Both groups significantly improved in pain NPRS score and KOOS at 6 months. At 12- and 24-month evaluations, the ASC group significantly decreased scores to a greater degree ( P < 0.001) than the PRP group. MOAKS scores indicated a decrease in disease progression in the ASC group. Conclusion Both ASCs and PRP were safe and resulted in clinical improvement in patients with knee OA at 6 months; however, at 12 and 24 months, ASCs outperformed leukocyte-poor PRP in clinical and radiological outcomes.

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Section: Discussionmentioning

confidence: 99%

Knee Osteoarthritis: Clinical and MRI Outcomes After Multiple Intra-Articular Injections With Expanded Autologous Adipose-Derived Stromal Cells or Platelet-Rich Plasma

Khoury,

Chamari,

Tabben

et al. 2023

CARTILAGE

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“…This misinformation may be linked to practitioners via social media, driven by patient testimonials, etc. [16,17]. This "wild west" part of social media may pose a threat to the credibility of physicians in general and specifically those who promote care on these platforms.…”

Section: The Social Media Influence and Influencers In Medicinementioning

confidence: 99%

New surgical techniques and social media in orthopaedics. Is a scientific peer-reviewed journal assimilated to a social media platform?

Scarlat¹,

Mavrogenis

Hernigou³

et al. 2022

International Orthopaedics (SICOT)

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“…2,3,7 Thus, journals and editors can play a critical role in evidence quality improvement by requesting mandatory adherence to reporting guidelines in the submission and reviewing process. 8 The orthopaedic scientific community still faces wide heterogeneity in platelet-rich plasma products, and building high-quality evidence from new studies is paramount. 5 In that sense, quantifying absolute platelet and leukocyte dose seems to be a key factor in improving patient-reported outcomes.…”

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confidence: 99%

Improving Injectable Orthobiologics Reporting Guidelines Adherence: Letter to the Editor

Fermín,

Laupheimer,

Khoury

2023

Am J Sports Med

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We have read with great interest the article ''Platelet-Rich Plasma Injections for the Treatment of Ankle Osteoarthritis'' by Paget et al,12 published in the American Journal of Sports Medicine.The authors have made a remarkable effort in conducting a randomized controlled trial on the use of platelet-rich plasma in ankle osteoarthritis in 98 patients, finding no improvement in ankle symptoms and function over 52 weeks compared with placebo injections.The body of evidence on platelet-rich plasma and other injectable orthobiologics is still growing. However, the reporting quality of these interventions remains poor despite the many guidelines developed by experts. 9,10 Several systematic reviews have shown that less than 10% of orthobiologics studies adequately report the implemented platelet-rich plasma preparation protocol, limiting their reproducibility and compromising their scientific value. 2,3,7 Thus, journals and editors can play a critical role in evidence quality improvement by requesting mandatory adherence to reporting guidelines in the submission and reviewing process. 8 The orthopaedic scientific community still faces wide heterogeneity in platelet-rich plasma products, and building high-quality evidence from new studies is paramount. 5 In that sense, quantifying absolute platelet and leukocyte dose seems to be a key factor in improving patient-reported outcomes. 1,4,6 Given this wide heterogeneity of platelet-rich plasma, claiming it does not work seems unfair in this context. Furthermore, for the flawless methodological quality of the present study, we kindly ask the authors for adequate reporting of the injected platelet-rich plasma product using the available guidelines. This information will contribute to abandoning this specific product, system, and protocol, which has been proven ineffective. 11,12 The present study is fundamental in moving the research toward other platelet-rich plasma products with different platelet doses and protocols rather than discouraging platelet-rich plasma implementation.

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Would you have an injection without knowing its formula? New challenges in platelet-rich plasma therapy

Cited by 9 publications

References 12 publications

Knee Osteoarthritis: Clinical and MRI Outcomes After Multiple Intra-Articular Injections With Expanded Autologous Adipose-Derived Stromal Cells or Platelet-Rich Plasma

Knee Osteoarthritis: Clinical and MRI Outcomes After Multiple Intra-Articular Injections With Expanded Autologous Adipose-Derived Stromal Cells or Platelet-Rich Plasma

New surgical techniques and social media in orthopaedics. Is a scientific peer-reviewed journal assimilated to a social media platform?

Improving Injectable Orthobiologics Reporting Guidelines Adherence: Letter to the Editor

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