Worldwide Incidence and Prevalence of Neuromyelitis Optica

Papp, Viktória; Magyari, Melinda; Aktaş, Orhan; Berger, Thomas; Broadley, Simon; Cabre, Philippe; Jacob, Anu; Kira, Jun Ichi; Leite, Maria Isabel; Marignier, Romain; Miyamoto, Katsuichi; Palace, Jacqueline; Sáiz, Albert; Sepúlveda, María; Sveinsson, Ólafur; Illés, Zsolt

doi:10.1212/wnl.0000000000011153

Cited by 146 publications

(113 citation statements)

References 64 publications

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“… 1 Recent worldwide epidemiological surveys showed differences in the regional and ethnic prevalence of NMOSD and a higher prevalence in Africans and non-whites. 2 , 3 Most patients with NMOSD have a relapsing-remitting course, with an increase in the number of relapses, a decrease in the recovery rate, an increase in the degree of disability, and, eventually, severe visual or motor impairment with progression of the disease. 4 Diagnosis of NMOSD is based mainly on clinical manifestations, AQP4 antibody status in serum or cerebrospinal fluid (CSF), and manifestations in the spinal cord or optic nerve seen on magnetic resonance imaging (MRI).…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio on Admission is an Independent Risk Factor for the Severity of Neurological Impairment at Disease Onset in Patients with a First Episode of Neuromyelitis Optica Spectrum Disorder

Zhou¹,

Xie²,

Zhao³

et al. 2021

NDT

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Purpose: To investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and the severity of neurological impairment at disease onset in patients with a first episode of neuromyelitis optica spectrum disorder (NMOSD). Patients and Methods: This retrospective study included 259 patients with newly diagnosed NMOSD who were hospitalized at our institution between January 2013 and January 2020 (NMOSD group) and 169 healthy control subjects who underwent a physical examination at our hospital during the same period (control group). The clinical data collected included general information, past medical history, biochemical test results, imaging findings, NLR, AQP-4 antibody status, and initial Expanded Disability Status Scale score. A logistic regression model was used to analyze NLR as an independent risk factor for the severity of neurological impairment at disease onset in the NMOSD group. Receiver-operating characteristic curve analysis was used to evaluate the ability of the NLR to predict the severity of neurological impairment at disease onset in the NMOSD group and to determine its critical value. Results: The NLR was significantly higher in the NMOSD group than in the control group (P<0.001). In the NMOSD group, neurological impairment at disease onset was more severe in those with a high NLR than in those with a low NLR (P<0.001). At onset of disease, patients with severe neurological impairment had a more significant increase in NLR than those with mild-to-moderate neurological impairment (P<0.001). Both univariate (OR 1.180, 95% CI 1.046-1.331, P=0.007) and multivariate (OR 1.146, 95% CI 1.003-1.308, P=0.044) logistic regression analyses showed that the NLR was positively correlated with the severity of neurological impairment at onset of disease in the NMOSD group. The area under the receiver-operating characteristic curve was 0.687. Conclusion:The NLR is an independent risk factor for the severity of neurological impairment at disease onset in patients with a first episode of NMOSD.

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Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio on Admission is an Independent Risk Factor for the Severity of Neurological Impairment at Disease Onset in Patients with a First Episode of Neuromyelitis Optica Spectrum Disorder

Zhou¹,

Xie²,

Zhao³

et al. 2021

NDT

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“…38 Asian countries have overall shown a higher prevalence of NMOSD compared to the west with prevalence ranging from 2.6 to 4.9/100 000 and incidence ranging between 0.39 and 0.6/100 000. 5 There is only one population-based study reported from India. From Mangalore in south west India, epidemiological studies revealed a prevalence of 2.6/100 000.…”

Section: Epidemiology Of Neuromyelitis Optica Spectrum Disordersmentioning

confidence: 99%

“…Global epidemiological studies suggest that it is more prevalent among non white populations. 4,5 Epidemiological studies on demyelinating disorders from India are limited. Most published reports are hospital-based reviews of medical records or from regional neurology centers.…”

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confidence: 99%

Epidemiology and clinical features of demyelinating disorders in India

Pandit

Mustafa

2021

Neurology & Clinical Neurosc

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In tropical countries like India, noncommunicable diseases have traditionally received less priority over infectious diseases. In recent times, however, demyelinating disorders of the central nervous system have become recognized as an important group of noncommunicable neurological disorders in India. It is possible that increasing awareness among doctors on one hand and availability of magnetic resonance imaging facilities (MRI) in teaching and private hospitals in the metropolitan cities of India on the other have contributed to early diagnosis and treatment.The study of demyelinating disorders of the nervous system in India has been limited by many factors. Kurtzke's 1 epidemiological studies pointed to India as having a low prevalence for multiple sclerosis (MS). Neuromyelitis optica (NMO) was considered a variant of MS. In the pre-MRI era, diagnosis of MS centered around clinical

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“…Neuromyelitis optica is a rare chronic inflammatory central nervous system disease characterized by monophasic or recurrent attacks of optic neuritis and transverse myelitis with poor or no recovery. [1][2][3] The term neuromyelitis optica spectrum disorder (NMOSD) was established by an international panel in 2015 to enable early diagnosis in patients with or without aquaporin-4 antibodies. 1 Motor and visual impairment, pain, and fatigue are among the most prevalent and debilitating symptoms.…”

Section: Introductionmentioning

confidence: 99%

Perception of Stigma in Patients with Neuromyelitis Optica Spectrum Disorder

Meca-Lallana¹,

Prefasi²,

Pérez‐Miralles³

et al. 2021

PPA

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Background Perception of stigma was associated with low self-esteem, psychological problems, and decreased health-seeking behavior among patients with different neurological disorders. The purpose of this study was to assess stigmatization and its impact in patients with neuromyelitis optica spectrum disorder (NMOSD). Methods A non-interventional study was conducted at thirteen neuroimmunology clinics in Spain. Patients with a diagnosis of NMOSD (2015 Wingerchuk criteria) were included. The 8-item Stigma Scale for Chronic Illness (SSCI-8), the Expanded Disability Status Scale (EDSS), the 29-item Multiple Sclerosis Impact Scale (MSIS-29), the Beck Depression Inventory-Fast Screen (BDI-FS), the MOS Pain Effects Scale (MOS-PES) and the Fatigue Impact Scale for Daily Use (D-FIS) were used to assess the perception of stigma, disability, quality of life, mood, pain, and fatigue, respectively. Associations between outcome measures were analyzed using Spearman’s rank correlation. Results Seventy-one patients were studied (mean age: 47.4 years ± 14.9, 81.7% female, mean time since disease onset: 9.9 years ± 8.1). The median EDSS score was 3.0 (interquartile range 1.5, 4.5). Stigma prevalence was 61.4% (n=43). Thirty-one patients (43.6%) had depression. The SSCI-8 score showed a significant correlation with both physical (rho=0.576, p<0.0001) and psychological (rho=0.608, p<0.0001) MSIS-29 scales scores, EDSS score (rho=0.349, p=0.0033), BDI-FS score (rho= 0.613, p<0.0001), MOS-PES score (rho= 0.457, p<0.0001), and D-FIS score (rho=0.556, p<0.0001). Conclusion Stigma is a common phenomenon affecting over 6 out of 10 patients with NMOSD. Understanding stigma may be useful to develop educational strategies improving NMOSD knowledge.

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Worldwide Incidence and Prevalence of Neuromyelitis Optica

Cited by 146 publications

References 64 publications

Neutrophil-to-Lymphocyte Ratio on Admission is an Independent Risk Factor for the Severity of Neurological Impairment at Disease Onset in Patients with a First Episode of Neuromyelitis Optica Spectrum Disorder

Neutrophil-to-Lymphocyte Ratio on Admission is an Independent Risk Factor for the Severity of Neurological Impairment at Disease Onset in Patients with a First Episode of Neuromyelitis Optica Spectrum Disorder

Epidemiology and clinical features of demyelinating disorders in India

Perception of Stigma in Patients with Neuromyelitis Optica Spectrum Disorder

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