Schematic representation and regression coefficients for the relationship between global cognitive performance and work demands mediated by social support. The standardized regression coefficients are shown in parentheses. The C represents the confounders for exposure-outcome (age, sex, race, education, income, hypertension, diabetes, body mass index, smoking, excessive alcohol use, common mental disorders, occupation type, hours of work per week and time in the workforce). The L represents the mediator-outcome confounders that are affected by the exposure (age, sex, education, income, common mental disorders, occupation type, hours of work per week and time in the workforce). Letters a and b represent the paths for indirect effect of mediation, whereas letter x represents the direct effect. The arrows represent the possible directions of the relationship between the work demands, social support, and cognitive performance. The dashed lines represent the covariate effects. *p < 0.05. C-reactive protein (CRP)