Woringer-Kolopp disease (localized pagetoid reticulosis) or unilesional mycosis fungoides? An analysis of eight cases with benign disease

Burns, M. K.

doi:10.1001/archderm.131.3.325

Cited by 29 publications

(47 citation statements)

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“…However, more recent studies unequivocally establish a T-cell lineage for the atypical epidermotropic cells (4, 8, 9, 14 -17). Further subtyping reveals three different phenotypes for the large epidermotropic cells, namely a CD4-positive T-helper phenotype (4,(17)(18)(19), CD8-positive T-cytotoxic/suppressor phenotype (4 -6, 9), or a CD4/CD8 double-negative phenotype (6,8,14,20). The results of the current study are in keeping with the observations described in the literature.…”

Section: Discussionsupporting

confidence: 88%

“…At least nine reported cases demonstrated lack of CD45RO staining (6,20,23). Conversely, at least four cases tested positive for CD45RO (18,19). In a more detailed analysis of the CD45 complex, Sterry and Hauschild (20) examined two cases of localized PR and found complete loss of the CD45 complex on the cell surface, as evidenced by lack of staining for CD45 (leukocyte common antigen), CD45RO (UCHL1), CD45RA (Leu18), and CD45RB (4KB5).…”

Section: Discussionmentioning

confidence: 96%

“…Another controversial aspect of PR is its relationship to MF (5,16,18,(27)(28)(29)(30)(31)(32). Much of the controversy arises from the clinical and microscopic similarities between the two entities, the lack of established diagnostic criteria for PR, and, as a result, different interpretations by different authors.…”

Section: Cd2mentioning

confidence: 99%

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Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study

et al. 2000

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Pagetoid reticulosis (PR), also known as WoringerKolopp disease, is a form of cutaneous T-cell lymphoma that demonstrates striking epidermotropism on histologic examination. We present the histologic, immunologic, and molecular findings for seven patients who had PR. The patients ranged in age from 33 to 67 years. All patients presented with one or several thick plaques involving the distal extremities except for one patient, who presented with a tongue lesion.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 96%

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Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study

et al. 2000

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“…The few reports appearing in the literature since 1981 [2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13], usually using the term ‘unilesional MF’ [3, 4, 5, 6, 7, 8, 9, 12], indicate that this variant of MF is rare, presenting as an isolated patch or plaque, generally indistinguishable clinically and histopathologically from typical MF. It follows a benign course for long periods without any treatment, and the initial reports stressed that there had been no case of disease recurrence after curative-intent treatment after variable follow-up periods [1, 2, 3, 4, 5, 6, 7].…”

Section: Introductionmentioning

confidence: 99%

“…It follows a benign course for long periods without any treatment, and the initial reports stressed that there had been no case of disease recurrence after curative-intent treatment after variable follow-up periods [1, 2, 3, 4, 5, 6, 7]. Very recent publications, however, indicate that there may be local recurrence [8, 9, 11, 13]and even relapse at distant sites after therapy such as radiotherapy [8].…”

Section: Introductionmentioning

confidence: 99%

Unilesional Mycosis fungoides

Hodak¹,

Phenig²,

Amichai

et al. 2000

Dermatology

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Background: Unilesional mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma (CTCL), characterized by a solitary lesion clinically and by histopathological features indistinguishable from those of MF, and typically having a benign course. Objective: To describe the clinicopathological features of a series of patients with unilesional MF. Methods: The records of cases of unilesional MF identified during a 10-year period in two medical departments were reviewed. Results: There were 7 patients: 6 males, 1 female; mean age at the time of diagnosis: 32 years; age range: 12–58 years; 3 were below the age of 18 years. The mean pretherapy follow-up period was 9 years (range: 2–20 years). In 5 patients, the eruption consisted of a characteristic patch or plaque of MF located on the trunk or upper extremity; in 2 it was atypical – in 1, a hypopigmented patch, and in 1, a plaque indistinguishable from MF-associated follicular mucinosis. Histopathologically all the lesions exhibited features characteristic of MF, with CD3+ lymphoid cells. In 6 cases (with available fresh frozen tissue) there was a predominance of CD3+ CD4+ cells; in 1 of 5 there was deletion of CD7, and in 3 of 5 there was an overexpression of IL-2 receptor. T-cell receptor γ gene rearrangement was found in 1 of 4 cutaneous lesions tested; in 2 cases it was found in the blood but not in the skin. Treatment modalities included localized electron beam, excision, topical nitrogen mustard or topical steroids and sunbathing, resulting in all cases in a sustained complete clinical response. In 1 patient, however, there were 2 local recurrences and in yet another patient there was distant cutaneous spread 3.5 years after therapy. Conclusions: Unilesional MF is a rare variant of CTCL, has heterogeneous clinical manifestations and can affect any age group, including children. The histopathological and immunophenotypical features are in general indistinguishable from those observed in multilesional MF. Although it is a unifocal event, there may occasionally be cutaneous spread with the appearance of noncontiguous lesions, even a long time after therapy. Whether all cases represent minimal-stage IA MF or whether some are actually T-cell pseudolymphoma remains to be clarified.

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Cutaneous Lymphomas and Lymphocytic Infiltrates

Whittaker

MacKie²

2010

Rook's Textbook of Dermatology

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Woringer-Kolopp disease (localized pagetoid reticulosis) or unilesional mycosis fungoides? An analysis of eight cases with benign disease

Cited by 29 publications

References 0 publications

Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study

Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study

Unilesional Mycosis fungoides

Cutaneous Lymphomas and Lymphocytic Infiltrates

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