Woman’s microbiota and pregnancy outcomes

Айламазян, Э. К.; Карпович, Айламазян Эдуард; Shipitsyna, Elena; Васильевна, Шипицына Елена; Savicheva, Alevtina M.; Михайловна, Савичева Алевтина

doi:10.17816/jowd6546-14

Cited by 9 publications

(2 citation statements)

References 46 publications

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“…Микробиоценоз влагалища находится в равновесии, пока естественная резистентность и иммунная система обеспечивают барьерную функцию [1,2]. Любая дисфункция микрофлоры влагалища во время беременности повышает восприимчивость к различным инфекциям, передаваемым половым путем (ИППП) [3][4][5][6], а инфекции в 40% наблюдений становятся причиной преждевременных родов и других осложнений гестации [6][7][8][9].…”

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Prevention of labor complication via the improvement of vaginal microbiocenosis

Karakhalis¹,

Ivantsiv²

2021

Russian Journal of Woman and Child Health

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Aim: to assess the effect of Lactobacilli on vaginal microbiocenosis in pregnant women with its pre-existing disturbances manifested as an increase in vaginal pH levels (>4.5) and pathological vaginal discharge in the 1st trimester of pregnancy. Patients and Methods: a prospective study involved 261 pregnant women who registered their pregnancy before 14 weeks. Group 1 included 147 women with vaginal pH>4.5 and gray white smelling discharge, but no cornified squamous epithelial cells and negative whiff test. Group 2 included 114 pregnant women with vaginal pH 3.8–4.5 and no vaginal discharge. At 11–14 weeks, 18–21 weeks, 30–34 weeks, and before delivery (36–41 weeks), vaginal pH, the composition of opportunistic flora, and Lactobacilli count were evaluated. In group 1, intravaginal lyophilized culture of L. casei rhamnosus (LCR) Doderleini was prescribed after each screening and before the delivery (in total, 4 courses). Results: the use of LCR preparation throughout the gestation reduced vaginal pH from 4.9 (11–14 weeks) to 4.5 (36–41 weeks) (p=0.001). In group 2, vaginal pH increased from 4.35 to 4.7 (p=0.000). In group 1 (probiotic containing LCR Lactobacilli was prescribed), the percentage of women with isolated L. jensenii strain increased by 1.6 times (from 9.52% to 14.96%). Meanwhile, in group 2 (no probiotic was prescribed), the percentage of women with isolated L. jensenii strain reduced by 4.2 times (from 14.91% to 3,51%; p=0.000). In group 1, abnormal birth activity and premature rupture of membranes were reported significantly less common (р=0.0001 and р=0.0001, respectively). Conclusions: probiotic containing LCR is favorable in terms of reducing the rate of pregnancy and birth complications. This fact is of particular importance for women who are at risk of bacterial vaginosis. KEYWORDS: pregnancy, Lactobacilli, vaginal microbiocenosis, pH measurement, probiotics. FOR CITATION: Karakhalis L.Yu., Ivantsiv N.S. Prevention of labor complication via the improvement of vaginal microbiocenosis. Russian Journal of Woman and Child Health. 2021;4(1):31–35. DOI: 10.32364/2618-8430-2021-4-1-31-35.

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Section: Introductionunclassified

Prevention of labor complication via the improvement of vaginal microbiocenosis

Karakhalis¹,

Ivantsiv²

2021

Russian Journal of Woman and Child Health

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“…Various authors report that 25-50% of women with infertility are diagnosed with endometriosis and the peritoneal form of endometriosis is accompanied by infertility in 60-80% of cases [6][7][8][9][10]. The meta-analysis by Barnhart [11] revealed that pregnancy rates in women with endometriosis were one half as high as in those of women with tubal pregnancy.…”

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How the therapy for endometriosis affects the hormonal status in female infertility

Педаченко

Shemelko²,

Tukhtarian

2020

J Educ Health Sport

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Aim. To determine changes in the values of pituitary and ovarian hormones in women with endometriosis-associated infertility, as well as to evaluate the impact of endometriosis therapy on hormonal parameters Materials and Methods. Sixty-nine women with small-sized endometriomas with adenomyosis (target group) and 50 women with tubal infertility (controls) were examined. The values of pituitary (luteinizing and follicle-stimulating hormones, prolactin) and ovarian (estradiol, tubular antimullerian hormone) hormones were studied. The comparison of 506 quantitative indicators between the studied groups of women was carried out using the Mann-Whitney U-test, the statistical significance of the results was assessed at a level of not less than 95% (risk of error not more than 5%-p <0.05). Results Infertile women with endometrioma and adenomyosis have lower AMH levels than infertile women with tubal factor. Among patients with endometriosis, there is an increase in serum FSH, LH, prolactin and estradiol compared with women without endometriosis. Dienogest moderately inhibits the secretion of FSH and LH; it has almost no effect on blood AMH and estradiol values. The use of dienogest can moderately increase the level of prolactin, It is noteworthy that these indicators are within the reference range. The use of diferelin for the treatment of endometriosis has a more active effect on the hormonal status of patients, given the decrease in such indicators as FSH and LH, AMH, estradiol and prolactin Conclusions. Women with infertility against the background of endometriosis have minor changes in the hypothalamic-pituitary-ovarian system, which indicates the need to develop medical measures in order to correct them. The use of dienogest compared to diferelin affects the hormonal status of patients with endometriosis to a lesser extent, given the pronounced anti-proliferative effect.

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Treatment of nonspecific vulvovaginitis in pregnant women: evaluation of the effectiveness of two-stage therapy

Shaposhnikova,

Majidli

2024

Rus. J. Hum. Repro.

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Woman’s microbiota and pregnancy outcomes

Cited by 9 publications

References 46 publications

Prevention of labor complication via the improvement of vaginal microbiocenosis

Prevention of labor complication via the improvement of vaginal microbiocenosis

How the therapy for endometriosis affects the hormonal status in female infertility

Treatment of nonspecific vulvovaginitis in pregnant women: evaluation of the effectiveness of two-stage therapy

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