Wolffian Duct Tumors: Case Reports and Review of the Literature

Ramírez, Pedro T.; Wolf, Judith K.; Malpica, Anaís; Deavers, Michael T.; Liu, Jinsong; Broaddus, Russell

doi:10.1006/gyno.2002.6739

Cited by 55 publications

(59 citation statements)

References 19 publications

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“…FATWO are rare neoplasms with only 71 cases having been reported. Since their original description by Kariminejad and Scully in 1973 (1), 8 cases with recurrent disease have been identified (2). Although they are considered to be a tumor of low malignant potential, they have the potential to recur and a few cases have been found to metastasize.…”

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confidence: 99%

Female Adnexal Tumor of Probable Wolffian Origin (FATWO) With Recurrence 3 Years Postsurgery

Syriac

Durie

Kesterson

et al. 2011

International Journal of Gynecological Pathology

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Summary This is the case report of a 38-year-old woman who presented with a mass of the right broad ligament that was diagnosed as a female adnexal tumor of probable Wollfian origin (FATWO). The patient was treated with a simple mass excision. Three years after the excision, the patient presented with uterine bleeding. A total abdominal hysterectomy was advised. Intraoperative histologic consultation showed a poorly differentiated tumor on the surface of the left ovary. After extensive immunohistochemistry analysis and after reviewing the histology slides from the primary tumor, the final diagnosis was concluded to be recurrent FATWO on the surface of the ovary. C-kit immunohistochemistry was found to be strongly positive. Polymerase chain reaction amplification of C-kit genes on exons 9, 11, 13, and 17 and of PDGFR gene on exons 12 and 18 showed no mutational changes. Owing to the limited options in treating recurrent disease and the lack of prognostic factors for recurrence or metastasis, the patient was started on 400 mg of imatinib mesylate therapy for 6 months. In addition, the patient is undergoing continuous follow-up by computed tomographic imaging every 6 months. As chemotherapy and radiation therapy for recurrent or metastatic FATWO are most often unsuccessful, a molecular targeted therapy, such as tyrosine kinase inhibitor, could be considered. However, collective data are needed from multiple centers to determine its effectiveness in these patients.

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confidence: 99%

Female Adnexal Tumor of Probable Wolffian Origin (FATWO) With Recurrence 3 Years Postsurgery

Syriac

Durie

Kesterson

et al. 2011

International Journal of Gynecological Pathology

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“…Immunohistochemical evidence for Wolffian remnants, such as immunoreactivity to pan-cytokeratin (AE1/3, CK1), CAM 5.2, cytokeratin 7 (CK7) and vimentin, make the diagnosis of FATWO more accurate [2,9].…”

Section: Discussionmentioning

confidence: 99%

“…Female adnexal tumors of probable Wolffian origin has been reported as immunoreactive for pancytokeratin (AE1/3, CK1) (100%), CAM 5.2 (100%), cytokeratin 7 (88%), keratin 903 (17%), EMA (12%), estrogen receptor (78%), inhibin (68%), calretinin (91%), and vimentin (100%) [2][3][4][5]. Ki-67 is a nuclear antigen expressed in proliferating but not resting cells, and it provides useful information concerning the growth potential of individual tissues and tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Kariminejad and Scully have reported nine cases and classified this type of tumor as FATWO based on its location, where the remnants of the Wolffian duct remain congenitally [1]. These tumors generally exhibit a low malignant potential, but recurrence and/or metastasis is possible during the course of the disease according to the tumors' possible malignant behavior [2]. The majority of these tumors have presented in the broad ligament with close proximity to the fallopian tube, paravaginal region and hilum ovarii [3].…”

Section: Introductionmentioning

confidence: 99%

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Female Adnexial Tumor of Probable Wolffian Origin (FATWO) without Ki-67 Expression Reflecting Low Malignant Potential in a 55-Year-Old Woman

Kahyaoğlu

Şirvan

Şengül

et al. 2012

EAJM

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Female adnexial tumors of probable Wolffian origin (FATWO) are rare tumors derived from the remnants of the mesonephric duct. These tumors generally exhibit a low malignant potential, but recurrence and or metastasis is possible during the course of the disease according to the tumors' possible malignant potential. We report a case of FATWO without estrogen and progesterone receptors and with negative immunostaining for Ki-67 (a proliferation marker) as a probable low-malignant-potential tumor. A 55-year-old woman presented with a complaint of heavy menstrual bleeding and pelvic pain. Preoperative ultrasonographic evaluation revealed an intramural uterine leiomyoma of 4 cm in diameter and a right adnexial solid mass measuring 5 cm in diameter. Following total abdominal hysterectomy and bilateral salpingo-oophorectomy, immunostaining based on the labeled streptavidin-biotin method was performed on sections from representative blocks of paraffin-embedded tissues sampled from the mass, revealing a low mitotic index with negative Ki-67 immunostaining. Immunohistochemical staining with promising new markers and pathological investigation of the entire tumor are needed to determine the malignant behavior of an individual FATWO. Ki-67 is a helpful marker for determining Wolffian duct tumors' potential malignant behavior.Key Words: FATWO, Immunostaining, Ki-67, Low malignant potential, Rare ÖzetMuhtemelen Wolff kaynaklı dişi adneksial tümörleri (FATWO) mezonefrik kanal artıklarından kaynaklanan nadir tümörlerdir. Bu tümör-ler genellikle düşük malign potansiyel gösterirler fakat olası malign davranışa göre rekürrensler ve/veya metazstaz da hastalığın gidişatı esnasında mümkümdür. Östrojen ve progesteron reseptörleri olmayan ve bu tip tümörler için düşük malign potansiyel özelliği olan Ki-67 proliferasyon işaretçisinin immün boyamada negatif olduğu bir FATWO olgusu sunuyoruz. Elli beş yaşında bir kadın ağır menstrüel kanama ve pelvik ağrı şikayeti ile başvurdu. Preoperatif ultrasonografik değerlendirme 4 cm uterin intramural myom ve sağ adnekste 5 cm çaplı solid bir kitleyi gösterdi. Total abdominal histerektomi ve bilateral salpingooforektomiyi takiben kitleden alınan doku örnekle-rinden hazırlanan parafin iliştirilmiş temsili bloklardan kesitler alına-rak işaretli streptavidin-biotin metodu bazlı immün boyama yapıldı ve Ki-67 ile immün boyanma göstermeyen düşük mitotik indekse sahip olduğu gösterildi. Hastanın fertilite isteğine bağlı olarak total abdominal histerektomi ve bilateral salpingooforektomi ile birlikte yapılan cerrahi debulking en uygun ilk cerrahi işlemdir. Bir FATWO hastasının malign davranışına karar vermeden önce yeni ümit verici işaretçilerle immünhistokimyasal boyanması ve tüm tümörün patolojik incelemesi gereklidir. Ki-67 Wolff kanalı tümörünün potansiyel malign davranışını tespit etmede yardımcı bir işaretçidir.

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“…There are few studies addressing PTCs in adolescents and no studies addressing PTCs in prepubertal females [3,[6][7][8][9][10]. Although malignancy has been described, it is extremely rare, with an incidence of 2% to 3% among those diagnosed with paratubal or paraovarian cysts [7,[11][12][13]. The goals for our study were to determine the incidence of PTCs in an adolescent population and to determine whether PTCs may occur in prepubertal females.…”

Section: Introductionmentioning

confidence: 98%

The incidence and surgical management of paratubal cysts in a pediatric and adolescent population

Muolokwu

Sanchez

Bercaw

et al. 2011

Journal of Pediatric Surgery

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Wolffian Duct Tumors: Case Reports and Review of the Literature

Cited by 55 publications

References 19 publications

Female Adnexal Tumor of Probable Wolffian Origin (FATWO) With Recurrence 3 Years Postsurgery

Female Adnexal Tumor of Probable Wolffian Origin (FATWO) With Recurrence 3 Years Postsurgery

Female Adnexial Tumor of Probable Wolffian Origin (FATWO) without Ki-67 Expression Reflecting Low Malignant Potential in a 55-Year-Old Woman

The incidence and surgical management of paratubal cysts in a pediatric and adolescent population

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