WMDA guidelines for subsequent donations following initial BM or PBSCs

Confer, Dennis L.; Shaw, Bronwen E.; Pamphilon, Derwood

doi:10.1038/bmt.2010.323

Cited by 20 publications

(12 citation statements)

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“…It is recommended that donors are counselled about the possibility of subsequent donations of stem cells or lymphocytes before their first donation. 34 Special regulations exist for donors who are donating on research protocols, 48 however, we do not discuss that here in detail as this is beyond the scope of this paper. The reporting of serious adverse events is mandatory for all WMDA-accredited registries, representing the vast majority of unrelated adult donations worldwide.…”

Section: Mechanisms To Ensure Donor Safetymentioning

confidence: 97%

“…Second donations of stem cells are not associated with an increased risk of donor complications, however, the need for adequate informed consent is clear. 34 Literature on the topic of RD safety has been scarce 5,6,13,14,21,[23][24][25]33,[35][36][37] and ARs are not as well characterized in terms of frequency and severity compared with URDs. Current research suggests that the risks associated with donation seem to be higher for RDs compared with URDs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A review of the haematopoietic stem cell donation experience: is there room for improvement?

Billen

Madrigal

Shaw

2014

Bone Marrow Transplant

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Donation of haematopoietic stem cells, either through BM or PBSC collection, is a generally safe procedure for healthy donors although adverse reactions are a definite risk. The invaluable source of donation and its central role in transplantation implies that every effort should be made to alleviate possible difficulties the donor encounters. The physical and psychological reactions to donation have been established for some time, but less is known about the factors that are associated with a poorer donation experience. In this article, we provide an overview of the physical and psychological donation experience and focus attention on demographic, physical and psychological factors that may influence this donation experience. Understanding that toxicity profiles vary with certain donor characteristics is crucial as this knowledge could influence practice in numerous ways including the modification of joining and recruitment policies and the improvement of supportive measures and donor follow-up procedures. Although this review deals with both unrelated and related donors (RDs), there is a relative paucity of regulation of RD care and we call for more attention to this area. Owing to the relative rarity of donation in each country, a global effort to collect donor outcome data is needed.

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Section: Mechanisms To Ensure Donor Safetymentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

A review of the haematopoietic stem cell donation experience: is there room for improvement?

Billen

Madrigal

Shaw

2014

Bone Marrow Transplant

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“…Finally, the National Marrow Donor Program recently reported follow-up from 43 donors who had donated twice to their recipient. 23 Again, rates of adverse reactions were found to be comparable between first and second donations.…”

Section: Introductionmentioning

confidence: 80%

Subsequent donation requests among 2472 unrelated hematopoietic progenitor cell donors are associated with bone marrow harvest

Lown

Tulpule

Russell³

et al. 2013

Haematologica

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© F e r r a t a S t o r t i F o u n d a t i o n 2 0 1 3to donate PBSC a second time. This may simply be a reflection of changing trends in hematopoietic progenitor cell harvest (PBSC harvest has become much more common in recent years) 1 , or may reflect the view that transplantation with peripherally harvested stem cells carries a lower risk of graft failure. 24 By contrast, little work has been published looking at donor attributes at first donation that may be associated with an increased likelihood of being requested to give a subsequent HPC donation. One study from the United Kingdom of 144 patients diagnosed with primary graft failure following transplantation suggested that the use of BM as the HPC source, female donors and HLA-mismatched grafts increased the risk of primary graft failure (and, consequently, a request for a subsequent donation). 25 In order to develop the evidence, and provide a sounder base for informed consent from its own unrelated donors, Anthony Nolan undertook a study of all second donations made by its HPC donors from 2005 to 2011. The objectives were to identify those donor and patient characteristics known by the registry at first donation that may be associated with a subsequent request for another HPC donation, to examine the safety of subsequent donations, and to compare harvest yields between first and subsequent donations. Importantly, this study was not aimed at examining patient factors predictive of the need for a second allograft. Methods Data collectionData were obtained retrospectively from records kept by Anthony Nolan for the period 2005-2011, during which time 2591 HPC donations were made by 2472 unrelated adult donors to 2493 recipients.During this study period, 145 requests for subsequent donations were made, of which 25 (17.4%) were later cancelled by the transplant center. There were three types of subsequent donation requests encountered in this study: 118 requests (group A, 81.4%) were to the same donor for the same patient as the initial donation; 21 (group B, 14.5%) were to a donor who had previously donated, but for a different patient and in six cases, patients requested (group C, 4.1%) a subsequent donation from a different donor.For the purposes of assessing an association between donor and patient characteristics at initial donation and the need for a subsequent donation (whether from the same or a different donor), all patients for whom there was a request for a subsequent donation were reviewed (i.e. excluding those donors in group B whose donations were being used for a first transplant for the recipient). For the purposes of assessing harvest yields and adverse events related to a second donation, all donors who had donated more than once were reviewed (i.e. excluding the group C donors who had donated only once).Thirteen (8.9%) of the donors who made a subsequent donation during the study period made their initial donation before 2005. As the statistical analysis relied on comparator data from those donors who made only a single donation, ...

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“…new stem cell mobilizers, increasing second (and subsequent) donation requests and the use of paediatric PBSC donors. These advances in the field of HSCT are posing already new medical and ethical questions [39,40].…”

Section: Resultsmentioning

confidence: 99%

Uniform examination of stem cell donors

Brand

2011

ISBT Science Series

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In contrast to unrelated donors who are counselled and examined according to international guidelines, related donors of allogeneic bone marrow (BM) or mobilized peripheral blood stem cells (PBSC) often are recruited, examined and followed otherwise. Currently, mostly PBSC instead of BM donation is used. The higher CD34+ yield is preferred for non-myeloablated recipients, allowing transplantation of older patients. Consequently related sibling donors are aging and prone to suffer more comorbidity as compared to unrelated donors. With respect to counselling it is obvious that donor recruitment and motivation between related and unrelated donors differ. The related donor however needs protection by an independent physician safeguarding the health of the donor. Although financial and logistic reasons may play a role, several differences between related and unrelated donor management are eligible for harmonization. In addition it is important to reach agreement among donor centres on uniform decisions for deferral and long-term follow-up. This requires exchange of information, not only of serious adverse reactions but also of potential hazardous situations, in order to develop more evidence-based recommendations.

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WMDA guidelines for subsequent donations following initial BM or PBSCs

Cited by 20 publications

References 8 publications

A review of the haematopoietic stem cell donation experience: is there room for improvement?

A review of the haematopoietic stem cell donation experience: is there room for improvement?

Subsequent donation requests among 2472 unrelated hematopoietic progenitor cell donors are associated with bone marrow harvest

Uniform examination of stem cell donors

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