WITHDRAWN: Relationship between breast density and selective estrogen-receptor modulators, aromatase inhibitors, physical activity, and diet-a diet – A systematic review

Ekpo, Ernest U.; Brennan, Patrick C.; Mello‐Thoms, Claudia; McEntee, Mark F.

doi:10.1016/j.ctrc.2015.07.002

Cited by 5 publications

(9 citation statements)

References 97 publications

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“…Some recent clinical trials of participants with radiographically dense breasts that compared breast cancer detection using mammography and concurrent MBI versus mammography alone reported a sensitivity of ~91% for mammography and concurrent MBI compared to 24–27% for mammography alone; both had similar specificities of 80–90% . These findings are especially promising in light of research suggesting that dense breasts are a predictor of breast cancer risk …”

Section: Introductionmentioning

confidence: 88%

“…9,10 These findings are especially promising in light of research suggesting that dense breasts are a predictor of breast cancer risk. [10][11][12][13][14][15] Currently, MBI images are purely qualitative. Quantitation of radiotracer uptake in MBI images has two potential utilities beyond cancer screening and detection: (a) comparison of absolute radiotracer uptake between benign and malignant tumors across patient populations and (b) assessing patient response to treatments such as neoadjuvant chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

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Quantitation of tumor uptake with molecular breast imaging

Bache

Kappadath

2017

Medical Physics

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Using DEW scatter- and our Volumetric GM attenuation-correction methodology yielded accurate estimates of tumor counts in MBI over various tumor sizes, shapes, depths, background uptake, and compressed breast thicknesses. Accurate tumor uptake can be converted to radiotracer uptake concentration, allowing three patient-specific metrics to be calculated for quantifying absolute uptake and relative uptake change for assessment of treatment response.

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Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Quantitation of tumor uptake with molecular breast imaging

Bache

Kappadath

2017

Medical Physics

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“…Лекарственные пре-параты и немедикаментозные методы лечения, сни-жающие риск рака МЖ, уменьшают МГП. Например, в ряде исследований увеличение потребления овощей и фруктов, кальция и витамина D, низкожировая ди-ета снижали МГП [32]. К настоящему времени селек-тивные модуляторы эстрогеновых рецепторов тамок-сифен и ралоксифен официально одобрены FDA (США) для химиопрофилактики рака МЖ, близки к одобрению ингибиторы ароматазы [33].…”

Section: опухоли женской репродуктивной системы Tumors Of Female Reprunclassified

“…В крупных интервенционных рандомизированных исследовани-ях доказано, что тамоксифен, ралоксифен и ингиби-торы ароматазы анастразол и экземестан при профи-лактическом применении существенно снижают риск развития рака МЖ [34]. В ряде исследований убеди-тельно доказано, что тамоксифен при длительном как профилактическом, так и лечебном приеме умень-шает МГП; в связи с этим МГП рекомендуется ис-пользовать в качестве промежуточного биомаркера оценки эффективности препаратов для химиопрофи-лактики рака МЖ [32,35].…”

Section: опухоли женской репродуктивной системы Tumors Of Female Reprunclassified

Mammographic Density as a Criterion of the Efficiency of Treatment of Benign Breast Disease and Reducing Risk of Breast Cancer

Беспалов¹,

Негусторов²

2017

Tumors of female reproductive system

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М а м м о л о г и я / M a m m o l o g y 2 ' 2 0 1 7 Том 13 / Vol. 13 ОПУХОЛИ ЖЕНСКОЙ РЕПРОДУКТИВНОЙ СИСТЕМЫ TUMORS OF FEMALE REPRODUCTIVE SYSTEM игина н стат иМаммографическая плотность как критерий эффективности лечения мастопатии и снижения риска рака молочной железы В. Г. Беспалов, Ю. Ф. Негусторов ФГБУ «НИИ онкологии им. Н. Н. Петрова» Минздрава России; Россия, 197758, Санкт-Петербург, пос. Песочный, ул. Ленинградская Health, Russia, 197758, Saint-Petersburg, Pesochny, Leningradskaya St., 68 High mammographic density (MD) is a risk factor of breast cancer. The article discusses the relationship between MD and risk of breast cancer and proliferative benign breast disease (BBD), the impact of BBD treatment on MD. The types of MD according to BI-RADS (Breast Imaging Reporting and Data System) are considered. High MD is an independent and strong risk factor for breast cancer, proliferative BBD and precancerous lesions in mammary tissue. Long-term pathogenetic treatment of BBD reduces MD. The drug progestogel, transdermal micronized progesterone, eliminates the imbalance of estrogens and progestins in the mammary tissue, which is the main pathogenic mechanism of the development of BBD. The clinical experience of the evaluation of the effect of progestogel on MD is presented. Progestogel ® in monotherapy was prescribed to patients with BBD in the form of cutaneous applications once a day, daily 2.5 g per each mammary gland for 3 months. Patients underwent 3 courses of treatment for 3 months with a break between courses of 1 month. Before the treatment and 1 year after the treatment, mammography was performed. Progestogel reduced MD in patients with BBD. Mammography with an evaluation of MD is recommended as an objective criterion for evaluating the efficiency of treatment of BBD and chemopevention of breast cancer.Key words: mammographic density, benign breast disease, BI-RADS system, prevention of breast cancer, progesterone, drug progestogel Введение Мастопатия -самое частое заболевание женщин. Распространенность мастопатии в женской популя-ции, по данным разных авторов, составляет до 60 %; причем патология имеет возрастные эпидемиологиче- До настоящего времени нет общепринятой терми-нологии и классификации мастопатии. Обычно к масто-патии относят все доброкачественные или нераковые

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“…Among the endogenous estrogens in the body, 17β‐estradiol (E2) binds to both ERs acting as a strong agonist . In recent years, researchers have paid more attention to the selective estrogen receptor modulators (SERMs), which play a different role in various cells and tissues . SERMs have been widely used for the treatment of osteoporosis and breast cancer in postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

Hepatocyte‐generated 27‐hydroxycholesterol promotes the growth of melanoma by activation of estrogen receptor alpha

Tian

Pang

et al. 2017

J of Cellular Biochemistry

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Cholesterol plays an important role in maintaining normal physiological function of human body. However, excessive intake will induce a series of diseases including cancer. For melanoma, the relationship between hypercholesterolemia and its incidence remains unknown. The cholesterol metabolite 27-hydroxy cholesterol (27-HC) catalyzed by CYP27A1 has been reported to activate estrogen receptor (ER). As studies have indicated that melanoma expresses ER, we designed experiments to explore whether 27-HC could link hypercholesterolemia and melanoma. In this study, hepatocyte-specific CYP27A1 mice were generated by CRISPR/Cas9 technology. The results revealed that high-cholesterol diet induced metabolism disorder and promoted the melanoma growth through 27-HC. Further study found that 27-HC promoted the growth of melanoma cells by activating ERα and eliciting the AKT and MAPK signaling pathway. This study puts forward the important role of 27-HC in the development of melanoma for the first time, links hypercholesterolemia with melanoma progression. The research also provides the rationale for the use of tamoxifen in melanoma therapy. The levels of 27-HC in blood could act as a novel biomarker for tamoxifen treatment in melanoma patients.

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WITHDRAWN: Relationship between breast density and selective estrogen-receptor modulators, aromatase inhibitors, physical activity, and diet-a diet – A systematic review

Cited by 5 publications

References 97 publications

Quantitation of tumor uptake with molecular breast imaging

Quantitation of tumor uptake with molecular breast imaging

Mammographic Density as a Criterion of the Efficiency of Treatment of Benign Breast Disease and Reducing Risk of Breast Cancer

Hepatocyte‐generated 27‐hydroxycholesterol promotes the growth of melanoma by activation of estrogen receptor alpha

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