WITHDRAWN: Impact of type 2 diabetes mellitus on coronary function evaluated by quantitative flow ratio in patients underwent percutaneous coronary intervention

Abstract

Background The co-existence of type 2 diabetes mellitus (T2DM) seems to reduce the therapeutic benefits from interventional technology in patients diagnosed with coronary artery disease (CAD). But the influence of T2DM on coronary disease still lacks the evidence from a perspective of functional assessment. Therefore, this study aimed to explore the impact of T2DM on coronary function in patients underwent percutaneous coronary intervention (PCI) through the new functional evaluation approach that is quantitative flow ratio (QFR). Methods Patients who underwent successful PCI and one-year angiographic follow-up were retrospectively screened and analyzed by QFR. Based on co-presence or absence of T2DM at the time of first admission or first discharge, 677 enrolled patients (794 lesions) were classifed into DM group (211 patients, 261 lesions) and Non-DM group (466 patients, 533 lesions). The post-PCI QFR, follow-up QFR, change value of QFR and incidence of functional restenosis were compared between the two groups. Results The two groups reached similar levels of post-PCI QFR (0.95 ± 0.09 vs. 0.96 ± 0.06, p = 0.292), but after one year follow-up, the degree of QFR decline in the DM group was more severe (-0.02 ± 0.09 vs. -0.01 ± 0.07, p = 0.023), leading to the follow-up QFR was lower than the Non-DM group (0.93 ± 0.11 vs. 0.96 ± 0.07, p < 0.001). What's more, the incidence of functional restenosis in the DM group increased significantly within one year (10.0% vs. 4.7%, p = 0.004). Conclusion T2DM can accelerate the functional decline of target coronary vessels after successful PCI.