WITHDRAWN: Altered oxidative stress indexes related to disease progression marker in human immunodeficiency virus infected patients with antiretroviral therapy

Gil, Lizette; Tarinas, Alicia; Hernández, Dayme; Riverón, Beatriz Vega; Pérez, Daniel I.; Tápanes, Rolando; Capó, Virginia; Pérez, Jorge

doi:10.1016/j.biopha.2010.09.009

Cited by 6 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been proposed that toxicological effects of antiretroviral drugs like myopathy, cardiomyopathy, anaemia, hyperlactataemia/lactic acidosis, pancreatitis, polyneuritis and lipodystrophy could be mediated through mitochondrial toxicity. Several studies relating oxidative stress with highly active antiretroviral therapy through mitochondrial dysfunction were reported by some scholars (Masia et al, 2007;Mandas et al, 2009;Gil et al, 2010;Sundaram et al, 2008). Mitochondria DNA inhibition may cause energy deprivation and increase reactive oxygen species formation.…”

Section: Antiretroviral Induced Oxidative Stress In Humansmentioning

confidence: 99%

“…Recent evidence showed that adjunct therapy with antioxidants may ameliorate these deleterious effects of highly active antiretroviral regimens containing protease inhibitors (Ben-Romano et al, 2006). Gil et al (2010) evaluated the effect of two highly active antiretroviral therapy (Zidovudine, Lamivudine, Indinavir) and (Stavudine, Lamivudine, Nevirapine) combinations on redox indicators. They reported increase in oxidative stress which occurred additionally to persistent redox imbalance associated with HIV-1 infection.…”

Section: Antiretroviral Induced Oxidative Stress In Humansmentioning

confidence: 99%

See 1 more Smart Citation

Antiretroviral Toxicity and Oxidative Stress

Adikwu

Nelson

Oputiri

et al. 2013

American Journal of Pharmacology and Toxicology

View full text Add to dashboard Cite

Antiretroviral drugs are used for the treatment of human immunodeficiency virus, they are used as combination regimens to achieve the highest possible benefit, tolerability, compliance and to diminish the risk of resistance development. Reports from preclinical and clinical studies have linked antiretrovirals with some toxicological effects which could be associated with redox imbalance (oxidative stress). This stimulated us to review relevant literature on the relationship between antiretroviral induced toxicological effects and redox imbalance. Available literature on antiretroviral associated toxicological effects and oxidative stress were comprehensively reviewed. Literature showed that antiretrovirals are associated with toxicological effects which includes hepatotoxicity, cardiotoxicity, hematotoxicity and nephrotoxicity. Reports in animal studies also showed that these toxicological effects could be associated with oxidative stress through the generation of oxidative radicals, depletion of antioxidants and antioxidant enzymes leading to mitochondria damage in the heart, kidney, liver brain and other organs. In humans, studies also showed that antiretrovirals are associated with lipid peroxidation, depletion of antoxidants and antioxidant enzymes which are elements of oxidative stress. Furthermore it was observed that supplementations with some antioxidants mitigated antiretroviral induced oxidative stress, mitochondria damage and toxicological effects. Antiretroviral drugs are associated with toxicological effects which may involve redox imbalance, but more studies are required to correlate antiretroviral toxicities with oxidative stress.

show abstract

Section: Antiretroviral Induced Oxidative Stress In Humansmentioning

confidence: 99%

Section: Antiretroviral Induced Oxidative Stress In Humansmentioning

confidence: 99%

Antiretroviral Toxicity and Oxidative Stress

Adikwu

Nelson

Oputiri

et al. 2013

American Journal of Pharmacology and Toxicology

View full text Add to dashboard Cite

show abstract

HIV-1, reactive oxygen species, and vascular complications

Porter

Sutliff

2012

Free Radical Biology and Medicine

View full text Add to dashboard Cite

Over 1 million people in the United States and 33 million individuals worldwide suffer from HIV/AIDS. Since its discovery, HIV/AIDS has been associated with an increased susceptibility to opportunistic infection due to immune dysfunction. Highly active antiretroviral therapies (HAART) restore immune function and, as a result, people infected with HIV-1 are living longer. This improved survival of HIV-1 patients has revealed a previously unrecognized risk of developing vascular complications, such as atherosclerosis and pulmonary hypertension. The mechanisms underlying these HIV-associated vascular disorders are poorly understood. However, HIV-induced elevations in reactive oxygen species, including superoxide and hydrogen peroxide, may contribute to vascular disease development and progression by altering cell function and redox-sensitive signaling pathways. In this review, we summarize the clinical and experimental evidence demonstrating HIV- and HIV antiretroviral therapy-induced alterations in reactive oxygen species (ROS) and how these effects likely contribute to vascular dysfunction and disease.

show abstract

Decreased IL-7 Responsiveness Is Related to Oxidative Stress in HIV Disease

et al. 2013

View full text Add to dashboard Cite

HIV disease results in decreased IL-7 receptor expression and IL-7 responsiveness in T cells. To explore mechanisms of these deficiencies, we compared CD127 expression and IL-7 induction of P-STAT5 in T cells from HIV-infected persons with serum concentrations of cytokines (IL-7, IL-6 and IL-15), markers of microbial translocation (sCD14 and LPS), and with an indicator of oxidative stress (malondialdehyde (MDA) adducts). CD127 expression was directly related to IL-7 responsiveness in most CD8+ T cell subsets but not in CD4+ T cells from HIV-infected persons. MDA adducts were increased in serum of HIV-infected patients and were inversely related to IL-7 responsiveness in CD8+ T cells and in central memory CD4+ T cells. Incubation of T cells from healthy controls with hydrogen peroxide resulted in impairments in IL-7 induction of P-STAT5. These findings suggest that oxidative stress that is characteristic of HIV disease could contribute to impairments in IL-7 responsiveness and disrupt T cell homeostasis.

show abstract

WITHDRAWN: Altered oxidative stress indexes related to disease progression marker in human immunodeficiency virus infected patients with antiretroviral therapy

Cited by 6 publications

References 42 publications

Antiretroviral Toxicity and Oxidative Stress

Antiretroviral Toxicity and Oxidative Stress

HIV-1, reactive oxygen species, and vascular complications

Decreased IL-7 Responsiveness Is Related to Oxidative Stress in HIV Disease

Contact Info

Product

Resources

About