Wireless Implantable Microsystems: High-Density Electronic Interfaces to the Nervous System

Wise, K.D.; Anderson, David J.; Hetke, J.F.; Kipke, Daryl R.; Najafi, K.

doi:10.1109/jproc.2003.820544

Cited by 574 publications

(323 citation statements)

References 121 publications

Supporting

Mentioning

314

Contrasting

Order By: Relevance

“…First, information regarding characteristics of the neuron is missing besides some clues on excitatory or inhibitory nature based on AP morphology and spike repetition rate (Csicsvári et al, 1999;Le Van Quyen et al, 2008;Ylinen et al, 1995 (Wise et al, 2004) and biofuel cell applications (Andoralov et al, 2013) reducing the need of recharging the portable amplifier's battery.…”

Section: Limitationsmentioning

confidence: 99%

Intracranial neuronal ensemble recordings and analysis in epilepsy

Tóth

Fabó

Entz

et al. 2016

Journal of Neuroscience Methods

View full text Add to dashboard Cite

Pathological neuronal firing was demonstrated 50 years ago as the hallmark of epileptically transformed cortex with the use of implanted microelectrodes. Since then, microelectrodes remained only experimental tools in humans to detect unitary neuronal activity to reveal physiological and pathological brain functions. This recording technique has evolved substantially in the past few decades; however, based on recent human data implying their usefulness as diagnostic tools, we expect a substantial increase in the development of microelectrodes in the near future.Here, we review the technological background and history of microelectrode array development for human examinations in epilepsy, including discussions on of wire-based and microelectrode arrays fabricated using micro-electro-mechanical system (MEMS) techniques and novel future techniques to record neuronal ensemble.We give an overview of clinical and surgical considerations, and try to provide a list of probes on the market with their availability for human recording. 2Then finally, we briefly review the literature on modulation of single neuron for the treatment of epilepsy, and highlight the current topics under examination that can be background for the future development.3

show abstract

Section: Limitationsmentioning

confidence: 99%

Intracranial neuronal ensemble recordings and analysis in epilepsy

Tóth

Fabó

Entz

et al. 2016

Journal of Neuroscience Methods

View full text Add to dashboard Cite

show abstract

“…Each processing element (PE) in the lattice of M PEs has a corresponding synaptic weight vector which has the same dimensionality as that of the input space. At every iteration, the synaptic weight closest to every input vector x k is found as shown in (4).…”

Section: A Som and Som-dlmentioning

confidence: 99%

“…Recently, attempts to develop wireless neuronal data transmission protocols has gained considerable attention [4]. Not only would this enable increased mobility and reduce risk of infection in clinical settings, but also would free cumbersome wired behavior paradigms where experimenter must overcome issues like entanglement, torque applied to prosthetics and chewing of cables.…”

mentioning

confidence: 99%

“…One solution is to perform spike detection on site, and then transmit spike signal only or the time at which the spike occurred [5]. An alternative is to use spike detection and sorting techniques so that binning (the number of spikes in a given time interval) can be immediately done [4]. The disadvantage of these methods lies in the weakness of current automated spike detection methods without human interaction as well as the missed opportunities of any post processing since the original waveform is lost.…”

mentioning

confidence: 99%

See 1 more Smart Citation

A Novel Weighted LBG Algorithm for Neural Spike Compression

Rao

Paiva

Prı́ncipe

2007

2007 International Joint Conference on Neural Networks

View full text Add to dashboard Cite

Abstract-In this paper, we present a weighted Linde-BuzoGray algorithm (WLBG) as a powerful and efficient technique for compressing neural spike data. We compare this technique with the recently proposed Self-Organizing Map with Dynamic Learning (SOM-DL) and the traditional SOM. A significant achievement of WLBG over SOM-DL is a 15dB increase in the SNR of the spike data apart from having a compression ratio of 150 : 1. Being simple and extremely fast, this algorithm allows real-time implementation on DSP chips opening new opportunities in BMI applications.

show abstract

“…Current applications extend to implantable neuroprosthetic devices [2] such as cochlear implants [3] and neural stimulating electrodes [4][5][6], as well as microfabricated devices targeting temperature, blood pressure, immuno-isolation, drug delivery, and microinjection [7,8]. Still, one critical issue has remained with respect to the power supply since stringent size constraints of the implant have compromised the available space required by batteries.…”

Section: Introductionmentioning

confidence: 99%

Thin film nanoporous electrodes for the selective catalysis of oxygen in abiotically catalysed micro glucose fuel cells

et al. 2016

View full text Add to dashboard Cite

Selective reduction of oxygen is an important property of fuel cells designed to operate in a mixed fuel environment containing both oxidizing and reducing reactants. This would be of particular importance in the design of a long lasting energy supply unit powering implantable microsystems and running from exogeneous chemicals that is abundant in the body (such as glucose and oxygen). This paper presents the development of a nanoporous electrode for oxygen reduction in the presence of glucose. The electrode was fabricated by e-beam deposition of palladium thin films on porous ceramic aluminium oxide (AAO) substrates with a pore size of 100 and 200 nm respectively. The porous nature of the electrodes improved the catalytic properties by increasing the real surface area close to 100 times the geometric surface area. At a dissolved physiological oxygen (DO) concentration of 2 ppm, the maximum exchange current density was found to be 2.9×10 −3 ± 0.5×10 −3 µA cm −2 whereas the potential reduction due to the addition of 5 mM glucose was about 20.6 ± 16.1 mV. The Tafel slopes were measured to be about 60 mV per decade. After running for 21 hours in a physiological saline solution with 2 ppm DO and 3 mM glu- cose, the reduction in the electrode operational potential was -0.13 mV h −1 under a load current density of 4.4 µA cm −2 . These results suggest that nanoporous AAO cathodes coated with palladium offers a reasonable catalytic performance with a good selectivity towards oxygen in the presence of glucose.

show abstract

Wireless Implantable Microsystems: High-Density Electronic Interfaces to the Nervous System

Cited by 574 publications

References 121 publications

Intracranial neuronal ensemble recordings and analysis in epilepsy

Intracranial neuronal ensemble recordings and analysis in epilepsy

A Novel Weighted LBG Algorithm for Neural Spike Compression

Thin film nanoporous electrodes for the selective catalysis of oxygen in abiotically catalysed micro glucose fuel cells

Contact Info

Product

Resources

About