Wilson Disease With an Initial Manifestation of Polyneuropathy

Abstract

Background: Recognition of Wilson disease (WD) is sometimes difficult because of its diverse manifestations. Peripheral neuropathy is rarely reported in the context of WD.Objective: To report an unusual patient with WD whose initial manifestation was peripheral neuropathy.

An unusual manifestation of Wilson disease presenting with burning feet syndrome

“…Wilson disease rarely leads to an affection of the peripheral nerve system [3][4][5][6]. Like in a previous case (association of Wilson disease and polyneuropathy) [3], we confirmed a mild myelin and axonal polyneuropathy. The major symptom was a burning feet syndrome.…”

An unusual manifestation of Wilson disease presenting with burning feet syndrome

“…Wilson disease rarely leads to an affection of the peripheral nerve system [3][4][5][6]. Like in a previous case (association of Wilson disease and polyneuropathy) [3], we confirmed a mild myelin and axonal polyneuropathy. The major symptom was a burning feet syndrome.…”

Moyamoya disease as a possible cause of neurological impairment following liver transplantation for Wilson's disease

“…Peripheral sensori‐motor polyneuropathy with both demyelinating and axonal involvement have also been reported as initial WD manifestations 6 . In our case, the observed neurological symptoms were paresthesias, strength reduction and altered fine motor skills.…”

The copper conundrum: a case of toxicity and altered mental status in a young male with opioid dependency

“…Their hypothesis pointed towards disruptions in copper metabolism affecting Schwann cells and myelin sheath 11. Subsequently, Leven et al and Jung et al also documented cases of peripheral neuropathy in individuals with Wilson's disease, further emphasizing that the role of copper metabolism in these fibers must be reconsidered 12,13. CONCLUSIONThis case report highlights the rarity of copper toxicity and its unusual manifestations, attributed to the precise homeostatic control in the body.…”

An unusual manifestation of Wilson disease presenting with burning feet syndrome

“…Wilson disease rarely leads to an affection of the peripheral nerve system [3][4][5][6]. Like in a previous case (association of Wilson disease and polyneuropathy) [3], we confirmed a mild myelin and axonal polyneuropathy. The major symptom was a burning feet syndrome.…”

Moyamoya disease as a possible cause of neurological impairment following liver transplantation for Wilson's disease

“…Peripheral sensori‐motor polyneuropathy with both demyelinating and axonal involvement have also been reported as initial WD manifestations 6 . In our case, the observed neurological symptoms were paresthesias, strength reduction and altered fine motor skills.…”

The copper conundrum: a case of toxicity and altered mental status in a young male with opioid dependency

“…Their hypothesis pointed towards disruptions in copper metabolism affecting Schwann cells and myelin sheath 11. Subsequently, Leven et al and Jung et al also documented cases of peripheral neuropathy in individuals with Wilson's disease, further emphasizing that the role of copper metabolism in these fibers must be reconsidered 12,13. CONCLUSIONThis case report highlights the rarity of copper toxicity and its unusual manifestations, attributed to the precise homeostatic control in the body.…”

An unusual manifestation of Wilson disease presenting with burning feet syndrome

“…Wilson disease rarely leads to an affection of the peripheral nerve system [3][4][5][6]. Like in a previous case (association of Wilson disease and polyneuropathy) [3], we confirmed a mild myelin and axonal polyneuropathy. The major symptom was a burning feet syndrome.…”

Moyamoya disease as a possible cause of neurological impairment following liver transplantation for Wilson's disease

“…Peripheral sensori‐motor polyneuropathy with both demyelinating and axonal involvement have also been reported as initial WD manifestations 6 . In our case, the observed neurological symptoms were paresthesias, strength reduction and altered fine motor skills.…”

The copper conundrum: a case of toxicity and altered mental status in a young male with opioid dependency

“…Their hypothesis pointed towards disruptions in copper metabolism affecting Schwann cells and myelin sheath 11. Subsequently, Leven et al and Jung et al also documented cases of peripheral neuropathy in individuals with Wilson's disease, further emphasizing that the role of copper metabolism in these fibers must be reconsidered 12,13. CONCLUSIONThis case report highlights the rarity of copper toxicity and its unusual manifestations, attributed to the precise homeostatic control in the body.…”