Wilms' tumour may also develop from impaired differentiation of the ureteric bud

Stupar, Zorica; Shan, Changliang; B, Veszprémi; Koesters, Robert; Stallmach, Thomas; Geng, JG; Kovács, Gyula

doi:10.1111/j.1365-2559.2007.02741.x

Cited by 4 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The exclusive role of metanephric blastema in the development of WT is challenged by Stupar et al, showing UB-derivative tubular structures in triphasic WTs (3). A recent comparative gene expression study selected genes expressed preferentially in the developing kidney and in WT and confirmed the occurrence of UB-like epithelial structures in triphasic WT using immunohistochemistry (4).…”

Section: Discussionmentioning

confidence: 99%

“…A recent global gene expression analysis uncovered genes expressed in distinct compartments of the developing kidney as well as in WT (4). The presence of UB-like epithelial structures in WT has been confirmed by immunohistochemistry (3,4). Recently, we showed that KRT17 expression is restricted to cells of the UB in foetal kidneys and, therefore, it can be used as biomarker to detect UB derivatives (5).…”

mentioning

confidence: 94%

See 1 more Smart Citation

Ureteric Bud-derivatives in Wilms Tumor and Nephrogenic Rest

Sarkany

Kovács

Banyai

2021

In Vivo

View full text Add to dashboard Cite

Background/Aim: Recent studies suggest that not only the nephrogenic blastema but also the ureteric bud is involved in oncogenesis of Wilms' tumor (WT). However, the occurrence of ureteric bud (UB) derivatives in nephrogenic rest is not yet known. The aim of our study was to find UB derivatives in WT. Materials and Methods: Keratin 17 (KRT17) is expressed exclusively in UB in foetal kidneys. In this study KRT17 immunohistochemistry was used to detect UB-derivatives in 21 triphasic, 2 stromal and 3 epithelial predominant WTs and 9 nephrogenic rests. Results: We have detected KRT17 positive tubular structures resembling UB in 3 of 9 nephrogenic rests and 15 of 26 WTs. Conclusion: Not only the metanephric blastema but also the UB is involved in the histogenesis of nephrogenic rest and WT.Wilms' tumor (WT) or nephroblastoma is suggested to develop from maturation-arrested nephrogenic blastemal cells (1, 2). However, in triphasic WTs the presence of ureteric bud (UB)-like tubular structures surrounded by blastemal cells appear to indicate the involvement of UB or UB-derivatives in the development of WTs (3). A recent global gene expression analysis uncovered genes expressed in distinct compartments of the developing kidney as well as in WT (4). The presence of UB-like epithelial structures in WT has been confirmed by immunohistochemistry (3,4). Recently, we showed that KRT17 expression is restricted to cells of the UB in foetal kidneys and, therefore, it can be used as biomarker to detect UB derivatives (5). To obtain more information on the involvement of UB in the histogenesis of WT and its precursor lesions, we analysed the expression of KRT17 in WTs and accompanying nephrogenic rests by immunohistochemistry.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 94%

Ureteric Bud-derivatives in Wilms Tumor and Nephrogenic Rest

Sarkany

Kovács

Banyai

2021

In Vivo

View full text Add to dashboard Cite

show abstract

“…The other has the appearance of a fully formed epithelial structure, which is negative for WT1 immunostaining, suggesting that this type of epithelial structure is equivalent to the UB and its derivative, the collecting duct [ 4 ]. However, in spite of other supporting evidence including morphology [ 2 , 3 ], lectin histochemistry [ 5 ] and ROBO1 and SLT2 immunohistochemistry [ 6 ], the presence of UB-like structures in WT remains unverified. This is possibly because a series of studies consistently demonstrated that WTs are monoclonal [ 7 – 9 ] which can be seen as inconsistent with the involvement of two different tissue origins.…”

Section: Introductionmentioning

confidence: 99%

The developmental programme for genesis of the entire kidney is recapitulated in Wilms tumour

et al. 2017

View full text Add to dashboard Cite

Wilms tumour (WT) is an embryonal tumour that recapitulates kidney development. The normal kidney is formed from two distinct embryological origins: the metanephric mesenchyme (MM) and the ureteric bud (UB). It is generally accepted that WT arises from precursor cells in the MM; however whether UB-equivalent structures participate in tumorigenesis is uncertain. To address the question of the involvement of UB, we assessed 55 Wilms tumours for the molecular features of MM and UB using gene expression profiling, immunohistochemsitry and immunofluorescence. Expression profiling primarily based on the Genitourinary Molecular Anatomy Project data identified molecular signatures of the UB and collecting duct as well as those of the proximal and distal tubules in the triphasic histology group. We performed immunolabeling for fetal kidneys and WTs. We focused on a central epithelial blastema pattern which is the characteristic of triphasic histology characterized by UB-like epithelial structures surrounded by MM and MM-derived epithelial structures, evoking the induction/aggregation phase of the developing kidney. The UB-like epithelial structures and surrounding MM and epithelial structures resembling early glomerular epithelium, proximal and distal tubules showed similar expression patterns to those of the developing kidney. These observations indicate WTs can arise from a precursor cell capable of generating the entire kidney, such as the cells of the intermediate mesoderm from which both the MM and UB are derived. Moreover, this provides an explanation for the variable histological features of mesenchymal to epithelial differentiation seen in WT.

show abstract

“…WT recapitulates the embryonal kidney development and may consist of blastemal cells as well as of tubular and papillary structures resembling all parts of the mature tubular system including collecting ducts, and also of glomeruloid bodies [10,12]. MTSCC, contrary to its official name, shows infrequently mucinous changes.…”

Section: Discussionmentioning

confidence: 92%

Expression of KRT7 and WT1 differentiates precursor lesions of Wilms’ tumours from those of papillary renal cell tumours and mucinous tubular and spindle cell carcinomas

Szponar

Kovács

2012

Virchows Arch

View full text Add to dashboard Cite

Wilms' tumours (WT) and adult papillary renal cell tumours (pRCT) are associated with precursor lesions of embryonic origin. The aim of this study was to analyse the expression of WT1, KRT7, KRT8, KRT18 and KRT19 genes by immunohistochemistry in 74 precursor lesions associated with WTs, pRCTs and mucinous tubular and spindle cell carcinomas (MTSCC). All precursor lesions associated with Wilms' tumours were positive for WT1, whereas all precursor lesions in pRCT and MTSCC-bearing kidneys were negative. None of the WT-associated lesions were positive for KRT7, but 69-80% of lesions associated with pRCTs and MTSCCs were positive for KRT7. KRT8, KRT18 and KRT19 were found to be expressed in 80-100% of all types of precursor lesions. Our findings indicate that the precursor lesions analysed in this study are committed in an early stage of cellular differentiation to the development of either Wilms' tumours or papillary RCTs and MTSCCs.

show abstract

Wilms' tumour may also develop from impaired differentiation of the ureteric bud

Cited by 4 publications

References 9 publications

Ureteric Bud-derivatives in Wilms Tumor and Nephrogenic Rest

Ureteric Bud-derivatives in Wilms Tumor and Nephrogenic Rest

The developmental programme for genesis of the entire kidney is recapitulated in Wilms tumour

Expression of KRT7 and WT1 differentiates precursor lesions of Wilms’ tumours from those of papillary renal cell tumours and mucinous tubular and spindle cell carcinomas

Contact Info

Product

Resources

About