Wie wirkt sich COVID-19 auf die intestinale Mikrobiota aus?

Konturek, Peter Christopher

doi:10.1007/s15006-021-0200-5

Cited by 4 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Исследования показали, что COVID-19 сопровождается нарушением кишечного микробиоценоза, сохраняющимся даже после успешной конверсии вируса (отрицательный результат ПЦР). В одном из исследований показано, что тяжесть течения COVID-19 может быть связана с микробиотой кишечника, при этом нарушение кишечного микробиоценоза может способствовать т. н. цитокиновому шторму [105].…”

Section: пробиотики в профилактике и лечении новой коронавирусной инф...unclassified

Disorders of intestinal microbiocenosis: expanding the application of probiotics

Трухан

2022

Medicinskij sovet

View full text Add to dashboard Cite

The problem of interaction between a person and the intestinal microbiome is surrounded by many secrets and mysteries. The bacterial flora of the gastrointestinal tract has a local and systemic effect not only on the digestive system, but also on the entire body as a whole. Numerous studies have proved the pathogenetic relationship of the state of the intestinal biocenosis not only with diseases of the gastrointestinal tract, but also with pathological processes from other organs and systems of the body. In terms of its role in maintaining homeostasis, the intestinal microflora is not inferior to any other vital organ. In the presented review, the current aspects of the terminology and clinic of disorders of intestinal microbiocenosis are considered. Probiotics occupy an important place in the complex therapy of intestinal microbiocenosis disorders and the corresponding clinical manifestations. The review considers the main mechanisms of probiotic / host interaction, non-immunological and immunological effects of probiotics and the requirements for them, the main directions of use of representatives of the normal microflora Bifidobacterium and Lactobacillus. The data of meta-analyzes and systematic reviews, testifying to the expansion of indications for the appointment of probiotics, are considered the possibilities of probiotics in the complex therapy of Helicobacter pylori infection, syndrome of increased epithelial intestinal permeability, and the prevention of respiratory infections.The review concludes with the results of a search in the PubMed database on the possibility of using probiotics in the prevention and treatment of a new coronavirus infection COVID-19. The availability of modern, effective and safe probiotics in the arsenal of a practical doctor (primarily a general practitioner and general practitioner), and their use, contributes to the optimization of drug therapy not only in gastroenterological patients, but also in patients with other somatic pathologies, including those with new coronavirus infection COVID-19.

show abstract

Section: пробиотики в профилактике и лечении новой коронавирусной инф...unclassified

Disorders of intestinal microbiocenosis: expanding the application of probiotics

Трухан

2022

Medicinskij sovet

View full text Add to dashboard Cite

show abstract

Can the Prognosis of COVID-19 Disease Be Determined by Fecal Markers and Cytokines?

Türkmen

Ünlü

Musayeva

et al. 2022

Journal of Interferon & Cytokine Research

View full text Add to dashboard Cite

Mechanisms of Potential Therapeutic Utilization of Mesenchymal Stem Cells in COVID-19 Treatment

et al. 2023

View full text Add to dashboard Cite

The 2019 novel coronavirus disease (COVID-19) has lasted for over 3 years and has seriously affected the regular life trajectory of human beings. The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has caused non-negligible harm to people’s respiratory systems and multiple organs. Although the pathogenesis of COVID-19 has been fully elucidated, there is still a lack of effective and specific treatment for COVID-19. Mesenchymal stem cells (MSCs) or MSC-derived extracellular vesicles (MSC-EVs) by far have become the most promising candidates in preclinical studies and clinical trials, and MSC-related therapies have shown their potential to treat severe COVID-19. The multidirectional differentiation potential and immunomodulatory function of MSCs have allowed the cells to exert multiple cellular and molecular actions on different immune cells and organs. It is critical to understand the therapeutic roles of MSCs before entering the clinics for COVID-19 and other diseases. This review summarizes the recent progress of particular mechanisms underlying the immunomodulatory and tissue regenerative effects of MSCs toward COVID-19. We focused on discussing the functional roles of MSC-mediated effects on immune cell responses, cell survival, and organ regeneration. Besides, the novel discoveries and recent findings of MSC clinical application in patients with COVID-19 were highlighted. This will provide an overview of the current research on the rapid development of MSC-based therapies not only for COVID-19 but also for other immune-mediated/immune-dysregulating diseases.

show abstract

Wie wirkt sich COVID-19 auf die intestinale Mikrobiota aus?

Cited by 4 publications

References 25 publications

Disorders of intestinal microbiocenosis: expanding the application of probiotics

Disorders of intestinal microbiocenosis: expanding the application of probiotics

Can the Prognosis of COVID-19 Disease Be Determined by Fecal Markers and Cytokines?

Mechanisms of Potential Therapeutic Utilization of Mesenchymal Stem Cells in COVID-19 Treatment

Contact Info

Product

Resources

About