Widespread Unilateral Pain Associated With Herpes Simplex Virus Infections

Kallio-Laine, Katariina; Seppänen, Mikko; Lokki, Marja-Liisa; Lappalainen, Maija; Notkola, Irma-Leena; Seppälä, Ilkka; Koskinen, Matti; Valtonen, Ville; Kalso, Eija

doi:10.1016/j.jpain.2008.02.003

Cited by 14 publications

(9 citation statements)

References 33 publications

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“…Our results demonstrated that chemokine genes showed the greatest upregulation, such as Cxcl13 (6.426 fold increase), suggesting that chemokines play a crucial role in the development of neuropathic pain. Furthermore, complements, a key component of the innate immune system and potentially important trigger of some types of neuropathic pain, have been associated with neuroinflammation [ 22 , 25 , 26 ]. Previous study showed that C1qc, C1qa, and Fcer1g might contribute to the generation of neuropathic pain after SNI via immune and defense pathways [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Analyses of gene expression profiles in the rat dorsal horn of the spinal cord using RNA sequencing in chronic constriction injury rats

Shi

Wang

et al. 2018

J Neuroinflammation

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BackgroundNeuropathic pain is caused by damage to the nervous system, resulting in aberrant pain, which is associated with gene expression changes in the sensory pathway. However, the molecular mechanisms are not fully understood.MethodsWistar rats were employed for the establishment of the chronic constriction injury (CCI) models. Using the Illumina HiSeq 4000 platform, we examined differentially expressed genes (DEGs) in the rat dorsal horn by RNA sequencing (RNA-seq) between CCI and control groups. Then, enrichment analyses were performed for these DEGs using Gene Ontology (GO) function, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, Hierarchical Cluster, and protein-protein interaction (PPI) network.ResultsA total of 63 DEGs were found significantly changed with 56 upregulated (e.g., Cxcl13, C1qc, Fcgr3a) and 7 downregulated (e.g., Dusp1) at 14 days after CCI. Quantitative reverse-transcribed PCR (qRT-PCR) verified changes in 13 randomly selected DEGs. GO and KEGG biological pathway analyses showed that the upregulated DEGs were mostly enriched in immune response-related biological processes, as well as 14 immune- and inflammation-related pathways. The downregulated DEGs were enriched in inactivation of mitogen-activated protein kinase (MAPK) activity. PPI network analysis showed that Cd68, C1qc, C1qa, Laptm5, and Fcgr3a were crucial nodes with high connectivity degrees. Most of these genes which have previously been linked to immune and inflammation-related pathways have not been reported in neuropathic pain (e.g., Laptm5, Fcgr3a).ConclusionsOur results revealed that immune and defense pathways may contribute to the generation of neuropathic pain after CCI. These mRNAs may represent new therapeutic targets for the treatment of neuropathic pain.Electronic supplementary materialThe online version of this article (10.1186/s12974-018-1316-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Analyses of gene expression profiles in the rat dorsal horn of the spinal cord using RNA sequencing in chronic constriction injury rats

Shi

Wang

et al. 2018

J Neuroinflammation

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“…In addition, spontaneous reactivation and shedding of infectious virus occurs at high levels in individuals latently infected with HSV [46,61], indicating that the natural immunity acquired following primary infection and subsequent reactivations is not sufficient to prevent subsequent spontaneous reactivations or shedding of infectious virus capable of spreading the infection. It also suggests that, in some individuals, natural immunity can completely control (prevent) recurrent disease (i.e., asymptomatic individuals), while in other individuals natural immunity is insufficient to prevent recurrent disease (symptomatic individuals), even though there is no apparent difference in virus shedding between these groups.…”

Section: Vaccination Approaches Against Herpes Infection and Diseasementioning

confidence: 99%

New concepts in herpes simplex virus vaccine development: notes from the battlefield

Dasgupta¹,

Chentoufi²,

Nesburn³

et al. 2009

Expert Review of Vaccines

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The recent discovery that T cells recognize different sets of herpes simplex virus type 1 and type 2 epitopes from seropositive symptomatic and asymptomatic individuals might lead to a fundamental immunologic advance in vaccine development against herpes infection and diseases. The newly introduced needle-free mucosal (i.e., topical ocular and intravaginal) lipopeptide vaccines provide a novel strategy that might target ocular and genital herpes and possibly provide 'heterologous protection' from HIV-1. Indeed, mucosal self-adjuvanting lipopeptide vaccines are easy to manufacture, simple to characterize, extremely pure, cost-effective, highly immunogenic and safe. In this review, we bring together recent published and unpublished data that illuminates the status of epitope-based herpes vaccine development and present an overview of our recent approach to an 'asymptomatic epitope'-based lipopeptide vaccine. †Author for correspondence

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“…These usually resolve gradually over days to weeks, but as demonstrated in this case, symptoms can persist for months [5, 12]. While case reports have suggested that effective antiviral medication provides moderate relief and speeds recovery, we did not observe a significant effect of pain moderation in our patient [13, 14]. …”

Section: Case Presentationmentioning

confidence: 50%

Hyperaesthesia Following Genital Herpes: A Case Report

Ooi¹,

Zawar²

2011

Dermatology Research and Practice

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We report an adult female patient who presented with sacral radiculopathy as incapacitating dysthesias following primary genital herpes simplex, which later recurred. Despite use of systemic antiviral treatment, the painful syndrome in our patient persisted. The success in treatment was seen only after the addition of amitriptyline hydrochloride. The case is being presented here for its rare manifestation and novel use of amitriptyline hydrochloride.

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Widespread Unilateral Pain Associated With Herpes Simplex Virus Infections

Cited by 14 publications

References 33 publications

Analyses of gene expression profiles in the rat dorsal horn of the spinal cord using RNA sequencing in chronic constriction injury rats

Analyses of gene expression profiles in the rat dorsal horn of the spinal cord using RNA sequencing in chronic constriction injury rats

New concepts in herpes simplex virus vaccine development: notes from the battlefield

Hyperaesthesia Following Genital Herpes: A Case Report

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