Cell Reports volume 5, issue 3, P781-790 2013 DOI: 10.1016/j.celrep.2013.09.043 View full text
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Prajwal Ciryam, Gian Gaetano Tartaglia, Richard I. Morimoto, Christopher M. Dobson, Michele Vendruscolo

Abstract: Summary The maintenance of protein solubility is a fundamental aspect of protein homeostasis, as aggregation is associated with cytotoxicity and a variety of human diseases. Numerous proteins unrelated in sequence and structure, however, can misfold and aggregate, and widespread aggregation can occur in living systems under stress or ageing. A crucial question in this context is why only certain proteins aggregate in vivo while others do not. We identify here the proteins most vulnerable to aggregation as tho…

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