Widening of the inferior alveolar canal: a case report with atypical lymphocytic infiltration of the nerve

Vartiainen, Veli Matti; Siponen, Maria; Salo, Tuula; Rosberg, Jukka; Apaja‐Sarkkinen, M.

doi:10.1016/j.tripleo.2008.05.063

Cited by 16 publications

(29 citation statements)

References 25 publications

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“…More sinister signs, such as a nonhealing tooth socket, may prompt consideration for malignancy. Up to 20% of cases report paresthesia [6], and in this case the presence of subtle widening of the left alveolar canal raised the clinical suspicion of malignancy, since widening of this canal has been previously reported in lymphoma [10–13]. …”

Section: Discussionmentioning

confidence: 86%

Minimally Invasive Diagnosis of Secondary Intracranial Lymphoma

McClement

Healy

Redmond

et al. 2016

Case Reports in Hematology

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Diffuse large B cell lymphomas (DLBCL) are an aggressive group of non-Hodgkin lymphoid malignancies which have diverse presentation and can have high mortality. Central nervous system relapse is rare but has poor survival. We present the diagnosis of primary mandibular DLBCL and a unique minimally invasive diagnosis of secondary intracranial recurrence. This case highlights the manifold radiological contributions to the diagnosis and management of lymphoma.

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Section: Discussionmentioning

confidence: 86%

Minimally Invasive Diagnosis of Secondary Intracranial Lymphoma

McClement

Healy

Redmond

et al. 2016

Case Reports in Hematology

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“…Both these investigation findings suggested the involvement of the inferior alveolar nerve which passes through the said foramen. A differential diagnosis for an ill-defined widening of the mandibular canal on imaging is lymphoma, although this finding is, by itself, rare 13. That being said, it is equally important to perform the relevant investigations to detect the presence of systemic malignancies in NCS 4.…”

Section: Discussionmentioning

confidence: 99%

Numb chin syndrome: an ominous sign of mandibular metastasis

Razak¹,

Goh

Rajaran³

et al. 2018

BMJ Case Reports

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A 51-year-old woman a known case of stage 2 breast carcinoma in 2006 and underwent left mastectomy performed in the same year presented with bilateral lower limb pain suggestive of spinal pathology, and left chin numbness, both of 2 weeks' duration. Examination revealed left mandibular hypoesthesia without any other sign or symptoms. Orthopantomogram was unremarkable apart from mild alveolar bone expansion at tooth 36 area, which was extracted 3 months earlier. Subsequently, a full-body positron emission tomography contrast enhanced computer tomography revealed hypermetabolic lesions of her axial (excluding skull) and appendicular skeleton. In the head and neck region, left mandibular foramen and oropharynx bilaterally showed increased metabolism suggestive of tumour metastasis. The diagnosis was numb chin syndrome secondary to mandibular metastasis. Apart from supportive treatment, she was started on palliative chemotherapy and radiotherapy. At the time of discharge, there were no active complaints other than the aforementioned hypoesthesia.

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“…Intraosseous schwannomas may sometimes cause distension of the inferior alveolar canal; they typically produce well-defined unilocular radiolucency mimicking an odontogenic cyst or a tumour. The other causes of mandibular canal widening like perineuroma, multiple endocrine neoplasia syndrome type 2b, vascular leiomyoma, arteriovenous malformation, and traumatic neuroma have been reported in the literature [8]. …”

Section: Discussionmentioning

confidence: 99%

“…Spherical radiolucency and enlargement in the (R) mandibular canal were appreciated in multislice CT [8]. No breach in the cortical plates was seen (Figure 1(e)).…”

Section: Case Reportmentioning

confidence: 99%

Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral Cancer

Sundar

Sherigar

Shetty

et al. 2016

Case Reports in Dentistry

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Perineural invasion is an underrecognized route of metastatic spread along the nerve bundles within the nerve sheath into the surrounding tissues. It hinders the ability to establish local control as tumour cells can traverse along nerve tracts well beyond the extent of any local invasion rendering them inoperable and unresectable. Perineural invasion is a marker of poor prognosis. Oral submucous fibrosis with oral cancer constitutes a clinicopathologically distinct disease. Our case highlights an enigmatic presentation of oral submucous fibrosis and its coexistence with oral cancer presenting with unusual neurological disturbance of the inferior alveolar nerve and facial nerve and diffuse widening of the mandibular canal. The objective of this case report is to enumerate the significance of perineural invasion in determining the course of the disease and necessitate the need for future studies that can shed light on molecular mediators and pathogenesis of perineural spread.

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Widening of the inferior alveolar canal: a case report with atypical lymphocytic infiltration of the nerve

Cited by 16 publications

References 25 publications

Minimally Invasive Diagnosis of Secondary Intracranial Lymphoma

Minimally Invasive Diagnosis of Secondary Intracranial Lymphoma

Numb chin syndrome: an ominous sign of mandibular metastasis

Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral Cancer

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