2019
DOI: 10.1038/s41564-019-0363-3
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Abstract: Methanogenesis is an ancient metabolism of key ecological relevance, with direct impact on the evolution of Earth’s climate. Recent results suggest that the diversity of methane metabolisms and their derivations have probably been vastly underestimated. Here, by probing thousands of publicly available metagenomes for homologues of methyl-coenzyme M reductase complex (MCR), we have obtained ten metagenome-assembled genomes (MAGs) belonging to potential methanogenic, anaerobic methanotrophic and short-chain alka… Show more

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Cited by 192 publications
(277 citation statements)
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References 78 publications
(118 reference statements)
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“…Interestingly, one archaeal genome (metabat2.27) obtained from the Bothnian Sea sediment was closely related to Methanomassiliicoccales but lacked Mcr and other several methanogenic biomarkers. It is related to several other genomic bins obtained from an aquifer (Anantharaman et al 2016) and together forms a separate lineage basal to the Methanomassiliicoccales lineage (Borrel et al 2019).…”
Section: Methanogenesis/-trophymentioning
confidence: 98%
“…Interestingly, one archaeal genome (metabat2.27) obtained from the Bothnian Sea sediment was closely related to Methanomassiliicoccales but lacked Mcr and other several methanogenic biomarkers. It is related to several other genomic bins obtained from an aquifer (Anantharaman et al 2016) and together forms a separate lineage basal to the Methanomassiliicoccales lineage (Borrel et al 2019).…”
Section: Methanogenesis/-trophymentioning
confidence: 98%
“…Significantly, phylogenetic profiling of the MA4545 locus revealed that homologs are absent in two hyperthermophilic methanogens ( Methanocaldococcus janaschiii and Methanopyrus kandleri ) that have been shown to lack S- methylcysteine within MCR (24). The phylogenetic tree of MA4545 is incongruent with both the MCR phylogeny and the reference phylogeny of archaea built with concatenated housekeeping genes (Figure 2B) (9, 11). Accordingly, it seems likely that a gene loss event and subsequent HGT event in the last common ancestor of the Methanosarcinaceae family is responsible for the shared ancestry of this locus between members of the Methanosarcina genus and the distantly related Methanobacteriales (Figure 2B).…”
Section: Resultsmentioning
confidence: 93%
“…All characterized MCRs contain a set of core and variable modified amino acids near the active site (1, 9, 24). For the last two decades, researchers have speculated on the role of these modifications vis-à-vis the function of MCR.…”
Section: Discussionmentioning
confidence: 99%
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“…The rapid advances in sequencing technology have led to a dramatic increase in available genome sequences. This genomic data has provided new perspectives on big questions in biology, such as the diversity of life, the distribution of metabolic traits across the tree of life, and the origin of eukaryotes (Hug et al 2016; Zaremba-Niedzwiedzka et al 2017; Borrel et al 2019). In addition, each newly available genome sequence contains novel protein sequences, yielding novel protein families of unknown function and expanding families with previously characterized representatives.…”
Section: Introductionmentioning
confidence: 99%