PurposeThe purpose of this paper is to investigate the impact of civil liberties, global health security, median age and population size on the spread of COVID-19 across the globe.Design/methodology/approachThis study was done by taking data from 166 different countries from the Economist Intelligence Unit, European Centre for Disease Prevention and Control, World Bank, Johns Hopkins University and United Nations Population Division (UNPD). After conducting all the necessary standard econometric tests, the study was analyzed using the ordinary least squares (OLS) regression.FindingsThe finding of the study indicated that COVID-19 tests per million people (LTT/PM), Population Size (LPOP), Civil Liberty Index (CLI) are statistically significant and positively affect the number of confirmed COVID-19 cases; on the other hand, the Health Security Index (HSI) negatively affects the number of confirmed COVID-19 cases.Practical implicationsIn emergency circumstances, the government ought to have a special responsibility to align civil rights with the protection of public health cautiously. However, measures to restrict civil liberties must be proportionate.Originality/valueBesides other variables, the study included and considered civil liberties as a significant factor to affect the spread of COVID-19, which is a new contribution to the existing body of knowledge in the field.