Why only areca nut chewing cannot cause oral submucous fibrosis?

Sarode, Sachin C.; Mahuli, Amit; Sarode, Gargi S; Mahuli, Simpy

doi:10.1016/j.mehy.2013.02.025

Cited by 22 publications

(24 citation statements)

References 18 publications

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“…Intriguingly, in OSCC group, 68.05% of cases gave history of habit of tobacco lime quid and betel nut chewing and still not having any signs of OSMF. These findings suggest that OSMF is a multifactorial disease and is not solely related to areca nut or any other ingredient in the quid (21). Recently, genetic predisposition for OSMF development has been reported in the literature (22).…”

Section: Discussionmentioning

confidence: 78%

Oral squamous cell carcinoma in the background of oral submucous fibrosis is a distinct clinicopathological entity with better prognosis

Gadbail

Chaudhary

Gawande

et al. 2017

J Oral Pathology Medicine

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Section: Discussionmentioning

confidence: 78%

Oral squamous cell carcinoma in the background of oral submucous fibrosis is a distinct clinicopathological entity with better prognosis

Gadbail

Chaudhary

Gawande

et al. 2017

J Oral Pathology Medicine

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“…Another important role of slaked lime is promoting the penetration of arecoline into the inflammatory oral mucosa. 19 This study reported the association between OSF stage and chewing habits. The extension of the duration of chewing areca nut and smoking tobacco did not increase the risk of advanced OSF (P > 0.05).…”

Section: Discussionmentioning

confidence: 92%

Oral submucous fibrosis: A clinicopathological study of 674 cases in China

Cai

Yao

Liu

et al. 2019

J Oral Pathology Medicine

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Background Oral submucous fibrosis (OSF) has been reported frequently in India and other countries in South Asia. There are few reports on the clinicopathological features of OSF in China, where OSF is an epidemic. This study analyses the clinicopathological features of OSF in Hunan Province, China. Methods A total of 674 cases of OSF were collected from July 2013 to August 2018 in Xiangya Stomatological Hospital, Central South University, and gender, age, site, pathological stage, habits, symptoms and associated lesions were recorded. Results The male to female ratio was 32.7:1. The average age was 35.23 ± 10.08. The buccal mucosa was the most common site. A total of 99.85% of OSF cases chewed areca nut. Pale mucosa, restricted mouth opening, burning and fibrous bands were common clinical manifestations. Oral leukoplakia (OLK) was the most common associated lesion. The extended duration of chewing areca nut increased the risk of associated lesions ( P < 0.05). The risk of OSF associated with OLK decreased with increasing OSF stage ( P < 0.05). Conclusion The prevalence of OSF in males was higher than that in females, the buccal mucosa was most affected, and chewing areca nut is the most common habit of OSF patients.

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“…Another interesting aspect of the work reported here is that ARD was about threefold more potent than ARC and ARC is reported to be converted into ARD in the presence of slaked lime, the latter of which is a common constituent of paan (10). Thus, the concentrations of ARC reported in the saliva of areca nut chewers (27) may actually underestimate the levels of biologically active alkaloids present.…”

Section: Discussionmentioning

confidence: 79%

“…Although the use of areca nut is widespread in the Far East, only a very small percentage of users develop OSMF and only a fraction of these patients develop neoplasia and cancer . At certain doses, ARC, which has been the most studied areca nut alkaloid can cause DNA damage, but there is no evidence that it can cause point mutations in vivo .…”

Section: Discussionmentioning

confidence: 99%