Why do UK‐born Pakistani babies have high perinatal and neonatal mortality rates?

Bundey, Sarah; Alam, Hasina; Kaur, Amandeep; Mir, Samina; Lancashire, Robert J.

doi:10.1111/j.1365-3016.1991.tb00689.x

Cited by 52 publications

(18 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the 11 year period between 1982 and 1992, the WMRCTRG registered 1420 cases of malignant disease in children under 15 years of age. Of these, 1188 were in white children, 161 in Asian children, 28 in Afro-Caribbeans, and 43 in children of other or mixed race.…”

Section: Resultsmentioning

confidence: 99%

Is the risk of cancer increased in Asians living in the UK?

Powell¹,

Parkes²,

Cameron³

et al. 1994

Archives of Disease in Childhood

View full text Add to dashboard Cite

The pattern of cancer in white and Asian (Indian, Pakistani, and Bangladeshi) children living in the West Midlands Health Authority Region was investigated using age standardised incidence rates. Two sets of rates were calculated, a 10 year rate using survey based estimates of the ethnic population and a four year rate using the ethnic population counts from the 1991 census. The 10 year rates showed a significantly higher annual incidence of cancer in Asian (159.1/million/year) than in white (130.8) children. The pattern of cancers in Asian children was different, with an excess of lymphomas and germ cell tumours, and a deficit of rhabdomyosarcomas. These findings were confirmed by the four year rates. Although under-

show abstract

Section: Resultsmentioning

confidence: 99%

Is the risk of cancer increased in Asians living in the UK?

Powell¹,

Parkes²,

Cameron³

et al. 1994

Archives of Disease in Childhood

View full text Add to dashboard Cite

show abstract

“…Consanguineous marriage, for which there is a cultural preference in many countries, is one important risk factor for mental retardation (MR) and other congenital disorders. This has been amply documented by a significant excess of (both severe and mild) MR in the progeny of consanguineous matings (Al-Ansari 1993;Bittles 2001;Bundey et al 1991;Durkin et al 1998;Fernell 1998;Kulkarni and Kurian 1990;Temtamy et al 1994;Yaqoob et al 1995) and finds further support in the linear correlation between the birth prevalence of congenital disorders and the coefficient of consanguinity observed by Bittles and Neel (1994). Both observations argue for a prominent role of autosomal recessive factors in the etiology of MR.…”

Section: Introductionmentioning

confidence: 92%

Autosomal recessive mental retardation: homozygosity mapping identifies 27 single linkage intervals, at least 14 novel loci and several mutation hotspots

et al. 2010

View full text Add to dashboard Cite

Mental retardation (MR) has a worldwide prevalence of around 2% and is a frequent cause of severe disability. Significant excess of MR in the progeny of consanguineous matings as well as functional considerations suggest that autosomal recessive forms of MR (ARMR) must be relatively common. To shed more light on the causes of autosomal recessive MR (ARMR), we have set out in 2003 to perform systematic clinical studies and autozygosity mapping in large consanguineous Iranian families with non-syndromic ARMR (NS-ARMR). As previously reported (Najmabadi et al. in Hum Genet 121:43-48, 2007), this led us to the identification of 12 novel ARMR loci, 8 of which had a significant LOD score (OMIM: MRT5-12). In the meantime, we and others have found causative gene defects in two of these intervals. Moreover, as reported here, tripling the size of our cohort has enabled us to identify 27 additional unrelated families with NS-ARMR and single-linkage intervals; 14 of these define novel loci for non-syndromic ARMR. Altogether, 13 out of 39 single linkage intervals observed in our cohort were found to cluster at 6 different loci on chromosomes, i.e., 1p34, 4q27, 5p15, 9q34, 11p11-q13 and 19q13, respectively. Five of these clusters consist of two significantly overlapping linkage intervals, and on chr 1p34, three single linkage intervals coincide, including the previously described MRT12 locus. The probability for this distribution to be due to chance is only 1.14 × 10(-5), as shown by Monte Carlo simulation. Thus, in contrast to our previous conclusions, these novel data indicate that common molecular causes of NS-ARMR do exist, and in the Iranian population, the most frequent ones may well account for several percent of the patients. These findings will be instrumental in the identification of the underlying genes.

show abstract

“…If both parents are from the same extended family, in particular, if they are first cousins, the chances of them each having the same recessive gene is increased (Lancet 1991). A high rate of first cousin marriage in Bradford Pakistanis and in their parents, irrespective of whether they were living in the UK or in Pakistan when they married (Bunday et al 1991) is, therefore, likely to increase the prevalence of autosomal recessive disorders and contribute to the infant mortality rate disproportionately in Pakistani babies.…”

Section: Discussionmentioning

confidence: 99%