Whole truths but half the blood: Addressing the gap between the evidence and practice of pre‐hospital and in‐hospital blood product use for trauma resuscitation

Hashmi, Zain G.; Chehab, Mohamad; Nathens, Avery B.; Joseph, Bellal; Bank, Eric A; Jansen, Jan O.; Holcomb, John B.

doi:10.1111/trf.16515

Cited by 24 publications

(21 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even in the United States, only 0.21% of hypotensive trauma patients received prehospital blood in 2019. 19 While the message might be getting out to the academic community, clinical practice still needs to catch up and should be the focus for the next few years.…”

Section: Discussionmentioning

confidence: 99%

“…This is especially true if the THOR message includes the use of prehospital blood, remembering most countries in the world still do not have access to prehospital blood. Even in the United States, only 0.21% of hypotensive trauma patients received prehospital blood in 2019 19 . While the message might be getting out to the academic community, clinical practice still needs to catch up and should be the focus for the next few years.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The publication impact of the first 100 THOR Network publications by bibliometric and social network analyses

Woolley

Stubbs

Sprague³

et al. 2022

Transfusion

View full text Add to dashboard Cite

Background A specialized international multidisciplinary group of investigators wanted to determine the performance and impact of publications presented at an annual conference over a 6 year period. Specifically, the group wanted to know if the influence of the conference publications extended beyond conference publication authors and attendees. Bibliometric methods and network analyses were used to evaluate the performance and impact of 100 peer‐reviewed publications presented at the Trauma Hemostasis and Oxygenation Research (THOR) Network Remote Damage Control Resuscitation (RCDR) Symposia from 2012 to 2017 (published 2013–2018). Further analysis was performed on the affiliations of conference attendees who attended from the years of 2012 to 2017. Study Design and Methods This project used normative and relative bibliometric measures and social network analysis to evaluate the performance and impact of 100 peer‐reviewed publications presented at the Trauma Hemostasis and Oxygenation Research (THOR) Network RDCR Symposia from 2012 to 2017. Publication and citation data were from Elsevier Scopus, a bibliographic citation database. Metrics from Elsevier SciVal were selected for the project to normalize for group size, year of publication, and document type. A six‐year period of publications presented at the Symposia, published from 2013 to 2018, was selected for analysis. The publication and citation data were further analyzed using Elsevier SciVal and the iCite database from the National Institutes of Health Office of Portfolio Analysis. Sci2, VOSviewer, and Gephi were used for social network analyses and visualization. Results The 100 publications presented at the Trauma Hemostasis and Oxygenation Research (THOR) Network Remote Damage Control Resuscitation (RCDR) Symposia from 2012 to 2017 demonstrate reach and influence beyond the authors of the THOR publications or the THOR attendees. Citations to the THOR publications were published in 10 languages and 313 unique journals, with author affiliations from 62 countries. Citation metrics for the THOR publications exceed global averages with 65% of the THOR publications being in the 25% citation percentiles. When benchmarking the THOR publications using six homogenous comparator groups, the THOR publications demonstrate higher citation metrics than any of the comparator groups with more citations per publication, a higher average of cited publications, higher FWCI and outputs in the top citation percentiles among the six groups. The Office of Portfolio Analysis (OPA) iCite database was used to calculate potential to translate for the THOR publications with 57 of the THOR publications cited by clinical articles with an average approximate potential to translate score of 65.3%. Conclusions The value of international groups with sharing of research and knowledge are instrumental in enhancing the uptake for best practices for in medicine and treatment of hemorrhagic shock resuscitation. The use of bibliometric methods and network analyses, along with benchmar...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The publication impact of the first 100 THOR Network publications by bibliometric and social network analyses

Woolley

Stubbs

Sprague³

et al. 2022

Transfusion

View full text Add to dashboard Cite

show abstract

“…In 2020, approximately 24% of all level 1 trauma centers in the United States used WB for resuscitation [32,33]. However, total WB utilization generally ranges from two to six units during prehospital transport [34][35][36].…”

Section: Modern Resuscitation In Civilian Environmentsmentioning

confidence: 99%

Hemorrhagic Resuscitation Guided by Viscoelastography in Far-Forward Combat and Austere Civilian Environments: Goal-Directed Whole-Blood and Blood-Component Therapy Far from the Trauma Center

Lantry

Mason

Logsdon

et al. 2022

JCM

View full text Add to dashboard Cite

Modern approaches to resuscitation seek to bring patient interventions as close as possible to the initial trauma. In recent decades, fresh or cold-stored whole blood has gained widespread support in multiple settings as the best first agent in resuscitation after massive blood loss. However, whole blood is not a panacea, and while current guidelines promote continued resuscitation with fixed ratios of blood products, the debate about the optimal resuscitation strategy—especially in austere or challenging environments—is by no means settled. In this narrative review, we give a brief history of military resuscitation and how whole blood became the mainstay of initial resuscitation. We then outline the principles of viscoelastic hemostatic assays as well as their adoption for providing goal-directed blood-component therapy in trauma centers. After summarizing the nascent research on the strengths and limitations of viscoelastic platforms in challenging environmental conditions, we conclude with our vision of how these platforms can be deployed in far-forward combat and austere civilian environments to maximize survival.

show abstract

“…In addition to FWB, low-titer group O whole blood (LTOWB) has been studied in the military setting with good success [39,41,45 ▪ ,47]. LTOWB is whole blood from type O donors with low levels of anti-A and ant-B IgM antibodies [48 ▪ ].…”

Section: Low-titer Group O Whole Bloodmentioning

confidence: 99%

Transfusion management in the trauma patient

Lewis

2022

Current Opinion in Critical Care

View full text Add to dashboard Cite

Purpose of reviewTransfusion of blood products is lifesaving in the trauma ICU. Intensivists must be familiar with contemporary literature to develop the optimal transfusion strategy for each patient. Recent findingsA balanced ratio of red-blood cells to plasma and platelets is associated with improved mortality and has therefore become the standard of care for resuscitation. There is a dose-dependent relationship between units of product transfused and infections. Liquid and freeze-dried plasma are alternatives to fresh frozen plasma that can be administered immediately and may improve coagulation parameters more rapidly, though higher quality research is needed. Trauma induced coagulopathy can occur despite a balanced transfusion, and administration of prothrombin complex concentrate and cryoprecipitate may have a role in preventing this. In addition to balanced ratios, viscoelastic guidance is being increasingly utilized to individualize component transfusion. Alternatively, whole blood can be used, which has become the standard in military practice and is gaining popularity at civilian centers.

show abstract

Whole truths but half the blood: Addressing the gap between the evidence and practice of pre‐hospital and in‐hospital blood product use for trauma resuscitation

Cited by 24 publications

References 21 publications

The publication impact of the first 100 THOR Network publications by bibliometric and social network analyses

The publication impact of the first 100 THOR Network publications by bibliometric and social network analyses

Hemorrhagic Resuscitation Guided by Viscoelastography in Far-Forward Combat and Austere Civilian Environments: Goal-Directed Whole-Blood and Blood-Component Therapy Far from the Trauma Center

Transfusion management in the trauma patient

Contact Info

Product

Resources

About