Whole Gland Primary Prostate Cryoablation: Initial Results From the Cryo On-Line Data Registry

Abstract

Whole gland cryoablation, practiced in a spectrum of academic and community users, maintains efficacy and morbidity similar to that of single center reports.

Initial Brazilian experience in the treatment of localized prostate cancer using a new generation cryotechnology: feasibility study

“…The percutaneous needle ablation simplifies surgery compared to other therapies such as open, laparoscopic or robotic prostatectomy. Outcomes from the Cryo On-Line Data registry reported that among the 1.198 consecutive patients who underwent primary cryoablation, 3.6% of patients developed urinary retention and 0.4% rates of recto-urethral fistulas (23). In our study, no recto-urethral fistula was observed.…”

“…They concluded that prostate cryoablation is a minimally invasive treatment with promising results, resulting in low complication rates for high risk patients with prostate cancer (24). Jones et al using the COLD registry database reported a 5-year BDFS in 1.198 patients using the Phoenix criteria of 91%, 78%, and 62% for low, moderate, and high risk respectively (23). Cohen et al demonstrated a 10 year BDFS of 80.6%, 74.2%, and 45.5% for low, moderate, and high risk patients using the Phoenix criteria (25).…”

Analysis of circulating regulatory T cells (CD4+CD25+CD127−) after cryosurgery in prostate cancer

“…These biochemical results compare quite favourably to the results of radiation therapy as a monotherapy. 21 A recent randomized trial comparing cryotherapy with radiation therapy reported similar biochemical outcomes and a significantly lower rate of positive post-treatment biopsies in the cryotherapy-treated patients. 22 Cryosurgery leaves tumour proteins and tumour-associated antigens intact.…”

“…The inclusion criteria were as follows: patients with prehormone therapy high-risk features of PCa, which were defined as either a prostate-specific antigen (PSA) level o10 ng ml 21 , a pathology report indicating a Gleason sum score o8, or both; no previous hormonal, immunosuppressive, or radiation therapy before this treatment; and no evidence of metastatic disease by bone scan, computer-assisted tomography, or magnetic resonance imaging. The patient characteristics are summarized in Table 1.…”

The Role of EphB4 and Ephrin-B2 Interactions in Prostate Cancer Models of Intravasation and Extravasation

“…Currently, these two treatment methods are used as primary treatments for men who are poor surgical candidates and want to avoid radiation therapy treatments [38]. However, local recurrence of PCa after CS or HIFU treatment has emerged as a serious problem for which a feasible management solution is still unknown [39,40]. There are conflicting recommendations for both CS and HIFU as alternative primary treatment options due to lack of controlled studies, limited follow-ups and limited information on cancer-specific survival.…”