Who should perform thyroid surgery? United Kingdom (UK) and United States (US) perspectives with recommendations

Smith, Joel; Watkinson, John; Shaha, Ashok R.

doi:10.1007/s00405-011-1794-5

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…Group 10 house dust mite allergen is conserved and cross-reactive with tropomyosin of species such as shellfish and other arthropods [26]. Furthermore, patients who are allergic to house dust mites show clinical symptoms when eating shellfish [27]. The prediction of cross-reactivity indicated a highly significant sequence match of SsTm with allergens of other mites.…”

Section: Discussionmentioning

confidence: 99%

Characterization and evaluation of a Sarcoptes scabiei allergen as a candidate vaccine

et al. 2012

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BackgroundSarcoptic mange caused by the mite Sarcoptes scabiei is a worldwide disease affecting both humans and animals. Here we report the molecular characterization and evaluation of a recombinant S. scabiei tropomyosin (SsTm) protein in a vaccination trial in rabbits.MethodsThe full-length cDNA was cloned in a bacterial pET vector, and the recombinant protein was expressed in BL21 (DE3) cells and purified. Using specific rabbit antiserum, tropomyosin was localized immunohistochemically in mite tissue sections. Vaccination trials with the recombiant SsTm was carried out in New Zealand rabbits.ResultsThe full-length open reading frame (ORF) of the 852 bp cloned gene from S. scabiei encodes a 32.9 kDa protein. The amino acid sequence showed 98.94%, 97.89% and 98.59% homology to Dermatophagoides farina and Dermatophagoides pteronyssinus group 10 allergens and Psoroptes ovis tropomyosin, respectively. Tropomyosin was localized immunohistochemically in mite tissue sections mainly in the mouthparts, legs and integument of the epidermis. The predicted cross-reactivity of SsTm indicated that it is an allergenic protein. While vaccination with the recombiant SsTm resulted in high levels of specific IgG (P < 0.01), a low IgE antibody response and no significant protection against S. scabiei challenge were observed. After challenge, specific IgG levels remained significantly higher than the control (P < 0.01), while changes of total IgE levels were not significant (P > 0.05). However, the lesion areas in the vaccination group decreased at the end of the experiment compared with controls.ConclusionsAlthough vaccination with recombinant SsTm did not efficiently control sarcoptic mange in rabbits, the immunogenic properties of tropomyosin suggest it may be developed as a vaccine with alternative adjuvants or delivery methods.

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Section: Discussionmentioning

confidence: 99%

Characterization and evaluation of a Sarcoptes scabiei allergen as a candidate vaccine

et al. 2012

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“…17 Indeed, operations like thyroid and parathyroid surgery are now performed primarily by ENT surgeons, rather than general and endocrine surgeons. 18 Similarly, there is a balance between plastic surgery and ENT and rhinoplasty surgery, although, nowadays, the further one goes away from the nose, the less the ENT surgeon is involved. 17 Additionally, skull base surgery is usually carried out in conjunction with neurosurgeons.…”

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confidence: 99%

The Semon Lectures and the foundation of modern ENT

Chapple

Watkinson

2021

J. Laryngol. Otol.

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Background Sir Felix Semon established the Semon Lecture series in 1913 to advance the specialty of laryngology. The annual lectures continue to the present day (there have been 95 to date). Objective This review illustrates how instrumental these lectures have been in shaping otolaryngology. Method The period 1913–1970 preceded subspecialisation, and so forms the background of laryngology (as well as rhinology and otology) as we know it today. This era forms the focus of the article. Results Changes came about by a standardisation of practices and research, and in the treatment of conditions. The initial period was crucial. Conclusion Many lectures highlight the specialty's growth. Now, another vital resource, a dedicated website (semonlectures.org), has made this information more accessible to the wider public.

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Recent Advances in Thyroid Surgery

Smith

Sadler

2013

Tips and Tricks in Endocrine Surgery

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Who should perform thyroid surgery? United Kingdom (UK) and United States (US) perspectives with recommendations

Cited by 7 publications

References 12 publications

Characterization and evaluation of a Sarcoptes scabiei allergen as a candidate vaccine

Characterization and evaluation of a Sarcoptes scabiei allergen as a candidate vaccine

The Semon Lectures and the foundation of modern ENT

Recent Advances in Thyroid Surgery

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