White sponge nevus

Jorgenson, R.J.

doi:10.1001/archderm.117.2.73

Cited by 25 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We can find these lesions in other common sites including the tongue, floor of the mouth, and alveolar mucosa 3,4.…”

Section: Introductionmentioning

confidence: 94%

“…Other histological findings include intracellular edema of the spinous layer cells 5. However, intracellular edema is not pathognomonic for WSN; in fact, the same aspect is present in other lesions, such as the leukoedema which is quite similar to WSN, even if it shows no parakeratosis 6. When we manage a patient affected by WSN no treatment is required onto these lesions, except for a clinical condition of a plaque which extends onto the lip vermilion: in this kind of cases, we perform a surgical exeresis for aesthetic reasons 7.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oral Infection by Staphylococcus Aureus in Patients Affected by White Sponge Nevus: A Description of Two Cases Occurred in the Same Family

Marrelli

Tatullo²,

Dipalma³

et al. 2012

Int. J. Med. Sci.

View full text Add to dashboard Cite

Introduction. White Sponge Nevus (WSN) is a rare pathology with a pathogenesis on genetic basis, a benign course and a localization affecting the mucosal keratin.WSN is usually a symptomless pathology: when pain is present, some authors reported reduction of symptoms by taking penicillin or oral tetracycline rinses, suggesting that a bacterial overinfection could be at the base of possible painful symptoms.Case Report. We describe 2 patients affected by WSN, father and son: they presented two different oral diseases associated with an infection by Staphylococcus aureus. So, we have performed a careful oral hygiene to reduce infection in the oral cavity. In the following days we prescribed 2 rinses a day with a mouthwash containing chlorhexidine digluconate at two different percentages.Discussion. Early diagnosis of this lesion is important, because it allows us to exclude other more serious diseases. In the most part of cases, WSN requires no treatment because of its benign and asymptomatic behaviour: up to now, no protocol of treatment for this condition was standardized. Even if WSN is a painless condition, sometime a correlated painful symptomatology was reported.Conclusions. In our experience, we have achieved excellent results even with chlorhexidine digluconate rinses, considering that our treated cases were both infected by Staphylococcus aureus.We hypothesize that the corrugated plaques and the altered texture of the mucosa create the right conditions for the colonization and the development of microbial species such as saprophytic bacteria or fungal species.

show abstract

“…We can find these lesions in other common sites including the tongue, floor of the mouth, and alveolar mucosa 3,4.…”

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Oral Infection by Staphylococcus Aureus in Patients Affected by White Sponge Nevus: A Description of Two Cases Occurred in the Same Family

Marrelli

Tatullo²,

Dipalma³

et al. 2012

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…Differential diagnosis in the present case includes white sponge nevus, which is characterized by spongy lesions mostly of the oral mucosa. Rarely, extraoral mucosa may be affected [5], and one case has been reported with white sponge nevus exclusively affecting the genital mucosa [6]. Histopathological findings in white sponge nevus are not specific and resemble the features of our case.…”

Section: Discussionmentioning

confidence: 49%

Palmoplantar Keratoderma and Leukokeratosis anogenitalis: The Second Case of a New Disease

Lautenschläger

Pittelkow

1998

Dermatology

View full text Add to dashboard Cite

An increasing number of syndromes with palmoplantar keratoderma (PPK) with associated diseases are being identified, representing a wide spectrum of distinct entities. At present only one case report has described the combination of marked anogenital leukokeratosis with diffuse PPK evolving in a collodion baby. We report a patient with a diffuse, nonprogressive PPK in combination with an intermittently pruritic, slowly progressive anogenital leukokeratosis. Hyperkeratosis of the perineal area was most pronounced and extended to the distal portion of the anal mucosa. The opalescent lesion was also visualized at the margin of the major labia. Vulvar structures were not otherwise involved or dystrophic. There were no signs or symptoms of ectodermal dysplasia. Specifically, the nails were normal and showed no signs of pachyonychia congenita. Other differential diagnoses included dyskeratosis congenita and white sponge nevus, which may be associated with anogenital leukokeratosis, but a keratoderma is not associated with these entities. Keratin immunocytochemistry showed marked expression of suprabasal K17 and absence of K6 and K16. Further examination of the initial case described by Itin and Rufli demonstrated the same expression pattern and supports the contention that these two cases represent the same entity.

show abstract

“…A controversy among authors exists about the longevity of the lesions. Some suggest that the disease remains stable throughout life, whereas others suggest persistence with alternate periods of remission and exacerbation ( 14 ). The lesions may become more pronounced during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Clinical features and molecular genetic analysis in a Turkish family with oral white sponge nevus

Kürklü¹,

Öztürk²,

Cassidy³

et al. 2018

Med Oral

View full text Add to dashboard Cite

BackgroundOral white sponge nevus (WSN) is a rare autosomal dominant benign condition, characterized by asymptomatic spongy white plaques. Mutations in Keratin 4 (KRT4) and 13 (KRT13) have been shown to cause WSN. Familial cases are uncommon due to irregular penetrance. Thus, the aim of the study was: a) to demonstrate the clinical and histopathological features of a three-generation Turkish family with oral WSN b) to determine whether KRT4 or KRT13 gene mutation was the molecular basis of WSN.Material and MethodsOut of twenty members of the family ten were available for assessment. Venous blood samples from six affected and five unaffected members and 48 healthy controls were obtained for genetic mutational analysis. Polymerase chain reaction was used to amplify all exons within KRT4 and KRT13 genes. These products were sequenced and the data was examined for mutations and polymorphisms.ResultsVarying presentation and severity of clinical features were observed. Analysis of the KRT13 gene revealed the sequence variant Y118D as the disease-causing mutation. One patient revealed several previously unreported polymorphisms including a novel mutation in exon 1 of the KRT13 gene and a heterozygous deletion in exon 1 of KRT4. This deletion in the KRT4 gene was found to be a common polymorphism reflecting a high allele frequency of 31.25% in the Turkish population.ConclusionsOral WSN may manifest variable clinical features. The novel mutation found in the KRT13 gene is believed to add evidence for a mutational hotspot in the mucosal keratins. Molecular genetic analysis is required to establish correct diagnosis and appropriate genetic consultation. Key words:White sponge nevus, leukokeratosis, oral mucosa, keratins, mutation.

show abstract

White sponge nevus

Cited by 25 publications

References 0 publications

Oral Infection by Staphylococcus Aureus in Patients Affected by White Sponge Nevus: A Description of Two Cases Occurred in the Same Family

Oral Infection by Staphylococcus Aureus in Patients Affected by White Sponge Nevus: A Description of Two Cases Occurred in the Same Family

Palmoplantar Keratoderma and Leukokeratosis anogenitalis: The Second Case of a New Disease

Clinical features and molecular genetic analysis in a Turkish family with oral white sponge nevus

Contact Info

Product

Resources

About