White Sponge Nevus of the Mucosa (Naevus Spongiosus Albus Mucosae)

A Case of Non-hereditary White Sponge Nevus in the Oral Cavity Successfully Treated with Tetracycline Ointment and Oral Multivitamins

“…A white sponge nevus (WSN) was first reported in 1909 by Hyde as an unusual nevus on the tongue of a five-year-old boy [4]. In 1935, Cannon named it "WSN [1]." Clinically, it has a white appearance, edematous mucosa, and spongy surface.…”

White sponge nevus: A condition not always clinically suspected

“…WSN is an uncommon benign autosomal dominant genodermatosis first reported by Hyde in 1909 that is usually detected at birth, although it may develop during adolescence . It affects about one in 200 000 people, and the condition often shows variable expressivity and irregular penetrance.…”

Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures

“…Furthermore, we found 13 BXD lines with low expression signals for Krt4 , Krt13 and Krtdap . Krt4 and Krt13 have been shown to be responsible for White sponge nevus (WSN), also known as Cannon's disease, which is an autosomal dominant skin condition in humans [ 45 - 47 ]. We propose that the 13 mouse strains have genetic alterations which result in low transcript levels of these genes and they may represent a good model for Cannon's disease.…”