2010
DOI: 10.1111/j.1369-1600.2010.00266.x View full text |Buy / Rent full text
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Abstract: Heroin addiction has been associated with impaired neuronal connectivity and cognitive deficits. One mechanism that potentially explains these findings is alterations in white matter connectivity secondary to chronic opiate use. However, few studies have quantitavely examined white matter deficits in opiate addiction (OA). Here, we investigated white matter microstructure in OA using diffusion tensor imaging (DTI). We performed voxel-wise analysis of fractional anisotropy (FA) in 24 participants with OA and 29… Show more

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“…On the other hand, heroin addicted individuals under methadone treatmentcompared to long-term abstinent heroin addicts presented an elevated ADC in corpus callosum's splenium bilaterally providing evidence that WM's damage might occur during abstinence. In agreement with the aforementioned findings, it was reported that decreased FA with increased radial diffusivity was found in the corpus callosum, ILF and thalamus of opiate-dependent subjects (Bora et al, 2010). Likewise, another study showed a decrease in the FA in the left cingulate and right precentral gyrus and also bilateral frontal sub-gyrusof heroin addicts (Liu et al, 2008).…”
Section: White Mattersupporting
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“…On the other hand, heroin addicted individuals under methadone treatmentcompared to long-term abstinent heroin addicts presented an elevated ADC in corpus callosum's splenium bilaterally providing evidence that WM's damage might occur during abstinence. In agreement with the aforementioned findings, it was reported that decreased FA with increased radial diffusivity was found in the corpus callosum, ILF and thalamus of opiate-dependent subjects (Bora et al, 2010). Likewise, another study showed a decrease in the FA in the left cingulate and right precentral gyrus and also bilateral frontal sub-gyrusof heroin addicts (Liu et al, 2008).…”
Section: White Mattersupporting
“…On the other hand, postmortem tracers have no practical value due to their glacial pace (Sparks et al, 2000). But, researchers are now equipped withmodern imaging technologies such as structural magnetic resonance (Liu et al, 2009a;Wang et al, 2012;Li et al, 2013a) or fMRI associated with voxel-based morphometry approach (Yuan et al, 2010b;Qiu et al, 2013), regional homogeneity tool , pharmacological MRI (phMRI) (Denier et al, 2013a) or fMRI combined to a pulsed arterial spin labeling (Denier et al, 2013b) and quantitative diffusion tensor imaging (Liu et al, 2008;Bora et al, 2010;Wang et al, 2011;Lin et al, 2012;Zhang et al, 2013).…”
Section: Resting-state Structural Deficits In Heroin Dependent Indivimentioning
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