White Matter Microstructure Changes in the Thalamus in Parkinson Disease with Depression: A Diffusion Tensor MR Imaging Study

Li, W.; Liu, J.; Skidmore, Frank; Liu, Y.; Tian, Jie; Li, K.

doi:10.3174/ajnr.a2195

Cited by 96 publications

(84 citation statements)

References 42 publications

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“…Of the 38 studies on depression, 33 reported findings from one single imaging modality: 19 used either PET [11, 12, 13,15, 16, 17, 18, 19] or SPECT 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30 techniques, four used T1‐weighted imaging 31, 32, 33, three used DTI 34, 35, 36, six used resting state functional MRI (RS‐FMRI) 37, 38, 39, 40, 41, 42 and two used TCS methods 43, 44. The remaining four of the 38 studies reported findings from structural T1‐weighted imaging plus another imaging method, including PET 14, DTI 45, task FMRI 46 and RS‐FMRI 47, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…The other two studies applying TCS demonstrated hypoechogenicity in the brainstem raphe in dPD patients as opposed to HCs and non‐depressed PD patients 43, 48. Using DTI techniques, three out of four studies reported compromised white matter connectivity indexed by decreased fractional anisotropy (FA) in various tracts, including the bilateral anterior cingulate cortex and thalamus and multiple tracts connecting to the left frontal and deep temporal lobes 34, 35, 36. However, one study reported a non‐significant group difference in the FA of the corpus callosum and uncinate fasciculus, a tract that interconnects the amygdala, hippocampus, temporal pole and the orbitofrontal cortex 45.…”

Section: Methodsmentioning

confidence: 99%

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Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies

Wen

Chan

Tan

et al. 2016

Euro J of Neurology

148

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Depression, anxiety and apathy are common mood disturbances in Parkinson's disease (PD) but their pathophysiology is unclear. Advanced neuroimaging has been increasingly used to unravel neural substrates linked to these disturbances. A systematic review is provided of neuroimaging findings in depression, anxiety and apathy in PD. A PubMed, MEDLINE and EMBASE search of peer‐reviewed original research articles on these mood disturbances in PD identified 38 studies on depression, eight on anxiety and 14 on apathy in PD. Most of the imaging studies used either position emission tomography or single‐photon emission computed tomography techniques. These studies generally suggest increased neural activity in the prefrontal regions and decreased functional connectivity between the prefrontal−limbic networks in depressed patients. Functional imaging studies revealed an inverse correlation between dopaminergic density in the caudate and putamen with the severity of anxiety in PD. There was no consistent correlation between dopaminergic density of thalamus and anxiety. Studies demonstrated both positive and inverse correlations between apathy and metabolism or activity in the striatum, amygdalar, prefrontal, temporal and parietal regions. The clinical variability of study subjects and differences in image pre‐processing and analytical strategies may contribute to discrepant findings in these studies. Both nigrostriatal and extra‐nigrostriatal pathways (in particular the frontal region and its connecting areas) are affected in mood disorders in PD. Identifying the relative contributions of these neural pathways in PD patients with overlapping motor and mood symptoms could provide new pathophysiological clues for the development of better therapeutic targets for affected patients.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies

Wen

Chan

Tan

et al. 2016

Euro J of Neurology

148

View full text Add to dashboard Cite

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“…These studies revealed that PD patients with depression had white matter reductions in the right anterior cingulate bundle, inferior orbitofrontal regions and in the left inferior parietal lobe [94], the frontal lobe bilaterally, possibly representing dysfunction in bilateral anterior cingulate bundles [96], and the mediodorsal nucleus of the thalamus bilaterally [95].…”

Section: Depressionmentioning

confidence: 96%

“…We found 11 imaging studies that have explored the neural bases of PD patients with and without depression using different imaging techniques [91][92][93][94][95][96][97][98][99][100][101] (See table 4). Among these studies, there is only one study that found no differences in brain regions between PD patients with and without depression [97] (In this study patients had mild to severe disease stages, average disease duration was 4.9 years and age at onset was 62.6).…”

Section: Depressionmentioning

confidence: 99%

Cognitive and neuroanatomical correlates of neuropsychiatric symptoms in Parkinson's disease: A systematic review

Alzahrani

Venneri

2015

Journal of the Neurological Sciences

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“…Subsequent investigations noted decreased fractional anisotropy values bilaterally in the mediodorsal thalamus correlating with increasing depression severity in Parkinson's disease patients, as assessed by the Hamilton Depression Scale. This suggests decreased viability of neurons or white matter fibers projecting to or from the mediodorsal thalamus [11]. A more recent DTI study, examining only the uncinate fasciculus as a region of interest, was unable to find a difference between depressed and nondepressed Parkinson's disease groups, in terms of fractional anisotropy values.…”

Section: Depression and Apathymentioning

confidence: 93%

Affective disorders in Parkinsonʼs disease

Aminian¹,

Strafella²

2013

Current Opinion in Neurology

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Purpose of review-This review explores recent literature pertaining to affective disorders associated with Parkinson's disease.Recent findings-Nonmotor symptoms including affective disorders are becoming more widely recognized as complications of Parkinson's disease. As awareness of these symptoms increases, and new neuroimaging tools are developed and become more accessible, more studies are being conducted pertaining to behavioral complications in Parkinson's disease. The functional connectivity of the basal ganglia can predispose people with Parkinson's to develop affective disorders. Furthermore, dopaminergic treatments may exacerbate or trigger behavioral symptoms. It is now understood that changes associated with Parkinson's disease are widespread, affecting striatal and extrastriatal regions and resulting in alterations in gray matter, white matter, blood flow, metabolism, and dopaminergic and serotonergic function. Summary-Neuroimaging is advancing our knowledge of the mechanisms involved inParkinson's disease, and their role in the development of behavioral disorders. An increased understanding of these disorders may lead to the discovery of new therapeutic targets, or the identification of risk factors for the development of these disorders. If preventive therapies become available, identification of risk factors will be important for the identification and treatment of susceptible individuals.

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White Matter Microstructure Changes in the Thalamus in Parkinson Disease with Depression: A Diffusion Tensor MR Imaging Study

Cited by 96 publications

References 42 publications

Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies

Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies

Cognitive and neuroanatomical correlates of neuropsychiatric symptoms in Parkinson's disease: A systematic review

Affective disorders in Parkinsonʼs disease

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