White matter loss in healthy ageing: A postmortem analysis

Piguet, Olivier; Double, Kay L.; Kril, Jillian J.; Harasty, Jenny; Macdonald, Virginia; McRitchie, D.A.; Halliday, Glenda M.

doi:10.1016/j.neurobiolaging.2007.10.015

Cited by 74 publications

(62 citation statements)

References 36 publications

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“…A previous study suggested that healthy brain ageing is a process affecting predominantly WM but not GM (Piguet et al, 2009). Hence, the reduction of GM volume found in Parkinson's patients in the present study probably has no link with aging.…”

Section: Grey Matter Volume Of Sensory Cortexcontrasting

confidence: 52%

Structural alteration of motor and sensory cortices in Parkinson’s disease using magnetic resonance imaging: Automatic brain segmentation

Shareef¹

2018

Int. j. adv. appl. sci.

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Parkinson's disease (PD) is a neurodegenerative disorder commonly diagnosed as motor triad of symptoms including tremor, rigidity and bradykinesia. The degeneration of the Substantia nigra in PD, leads to alterations in the function of cortical areas including primary motor cortex and other non-primary motor areas. The combination of motor and sensory symptoms marked in PD, is the cause of investigating the structural changes of motor and sensory cortices in PD. The aim of this study is to detect the structural changes of cortical thickness and the volume of grey matter and white matter in motor and sensory cortices in PD. This will help in early detection of the disease, monitor response to medication or help in prognosis and prediction of outcomes. Nineteen control volunteers and 18 Parkinson's patients were participated in the study. The ages of participants were ranging between 45-65 years (mean 56.14 years). Structural magnetic resonance imaging was performed and the Digital Imaging and Communications in Medicine (DICOM) images were evaluated using automatic brain segmentation software (BrainSuite). The structural changes in the present study were found in the thickness of the motor cortex and in the volume of grey matter (GM) of the sensory cortex. The thickness of the right motor cortex for males was smaller in Parkinson's patients than control. The volume of the GM of left sensory cortex for males was smaller in Parkinson's patients than control. While no differences were found between Patients and controls in the volume of GM or white matter (WM) in the motor cortex, or in the volume of WM and the cortical thickness in the sensory cortex. Structural changes in specific areas of the brain may influence specific symptoms.

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Section: Grey Matter Volume Of Sensory Cortexcontrasting

confidence: 52%

Structural alteration of motor and sensory cortices in Parkinson’s disease using magnetic resonance imaging: Automatic brain segmentation

Shareef¹

2018

Int. j. adv. appl. sci.

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“…Frontal lobe WMLs have been shown to be associated with neurofibrillary pathology, particularly in the oldest old, while there was no relationship with neocortical Aβ load [125]. Routine histological assessment may underrate mild to moderate subcortical vascular lesions, but MRI imaging of fixed post-mortem brains reliably reflects subcortical vascular pathology of the white matter [126],[127]. …”

Section: Reviewmentioning

confidence: 99%

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

Attems

Jellinger

2014

BMC Med

567

420

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Recent epidemiological and clinico-pathological data indicate considerable overlap between cerebrovascular disease (CVD) and Alzheimer’s disease (AD) and suggest additive or synergistic effects of both pathologies on cognitive decline. The most frequent vascular pathologies in the aging brain and in AD are cerebral amyloid angiopathy and small vessel disease. Up to 84% of aged subjects show morphological substrates of CVD in addition to AD pathology. AD brains with minor CVD, similar to pure vascular dementia, show subcortical vascular lesions in about two-thirds, while in mixed type dementia (AD plus vascular dementia), multiple larger infarcts are more frequent. Small infarcts in patients with full-blown AD have no impact on cognitive decline but are overwhelmed by the severity of Alzheimer pathology, while in early stages of AD, cerebrovascular lesions may influence and promote cognitive impairment, lowering the threshold for clinically overt dementia. Further studies are warranted to elucidate the many hitherto unanswered questions regarding the overlap between CVD and AD as well as the impact of both CVD and AD pathologies on the development and progression of dementia.Electronic supplementary materialThe online version of this article (doi:10.1186/s12916-014-0206-2) contains supplementary material, which is available to authorized users.

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“…WM changes with age include a loss in volume, decreased myelin staining, and increased pallor (Kemper 1994). Histological studies have reported a 10-15% loss of myelinated fibers with age (Meier-Ruge et al 1992;Tang et al 1997;Marner et al 2003) and a decline in WM volume (Tang et al 1997;Marner et al 2003;Piguet et al 2009). While important, these studies have limitations that include variable tissue quality, small sample number, a lack of functional correlates, and a cross-sectional design that makes it difficult to discern progression and trajectory of change.…”

mentioning

confidence: 99%

Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline

Kohama

Rosene

Sherman

2011

AGE

117

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The cognitive decline associated with normal aging was long believed to be due primarily to decreased synaptic density and neuron loss. Recent studies in both humans and non-human primates have challenged this idea, pointing instead to disturbances in white matter (WM) including myelin damage. Here, we review both cross-sectional and longitudinal studies in humans and non-human primates that collectively support the hypothesis that WM disturbances increase with age starting at middle age in humans, that these disturbances contribute to age-related cognitive decline, and that age-related WM changes may occur as a result of free radical damage, degenerative changes in cells in the oligodendrocyte lineage, and changes in microenvironments within WM.

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White matter loss in healthy ageing: A postmortem analysis

Cited by 74 publications

References 36 publications

Structural alteration of motor and sensory cortices in Parkinson’s disease using magnetic resonance imaging: Automatic brain segmentation

Structural alteration of motor and sensory cortices in Parkinson’s disease using magnetic resonance imaging: Automatic brain segmentation

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline

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