White matter (dis)connections and gray matter (dys)functions in visual neglect: Gaining insights into the brain networks of spatial awareness

Doricchi, Fabrizio; Schotten, Michel Thiebaut de; Tomaiuolo, Francesco; Bartolomeo, Paolo

doi:10.1016/j.cortex.2008.03.006

Cited by 308 publications

(173 citation statements)

References 76 publications

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“…the patient remained unaware of this deficit probably due to an involvement of the white matter tracts responsible for visual awareness -the inferior fronto-occipital fasciculus, which runs in the depth of the temporal lobe, and the arcuate fasciculus and the superior longitudinal fasciculus which connect the frontal and parietal regions. disconnections 43 and hypoperfusion of white matter tracts have been shown to cause visual awareness deficits 44 . the t2 FLaIr hyperintense signal in that area suggests the presence of gliosis and supports this hypothesis.…”

Section: Acknowledgmentsmentioning

confidence: 99%

Brain Reorganization after Endovascular Treatment in a Patient with a Large Arteriovenous Malformation: The Role of Diagnostic and Functional Neuroimaging Techniques

et al. 2013

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We describe a case of brain cortical reorganization after embolization of a large right temporal arteriovenous malformation. A comprehensive imaging protocol, including functional magnetic resonance imaging (fMRI), cortical thickness analysis and 320-row computed tomography (CT) perfusion was used to provide information on brain plasticity and potential steal phenomenon. A 25-year-old man known for a right temporal grade V Spetzler-Martin classification arteriovenous malformation (AVM) presented with left progressive hemiparesis. He underwent functional 3T magnetic resonance imaging (fMRI), cortical thickness analysis, and CT perfusion (CT 320 row, Aquilion ONE, Toshiba, Tokyo, Japan) before and after endovascular treatment. The results were compared to look for modifications in brain perfusion and organization. An improvement in the left hemiparesis and a reorganization of motor function were observed after endovascular treatment. Modifications in the angioarchitecture and perfusion of an extensive AVM may be accompanied by a functional and structural reorganization of the brain. The location in the so-called eloquent regions may not be sufficient to explain the wide spectrum of symptoms that these patients can present. A more comprehensive approach considering a global involvement of the brain in patients with large AVMs is suggested to achieve the best treatment strategy and to stage treatment in incurable AVMs.

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Section: Acknowledgmentsmentioning

confidence: 99%

Brain Reorganization after Endovascular Treatment in a Patient with a Large Arteriovenous Malformation: The Role of Diagnostic and Functional Neuroimaging Techniques

et al. 2013

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“…The unilateral spatial neglect results from a unilateral hemispheric lesion (most often in the right hemisphere) that involves inferior and superior parietal lobes, some portions of the frontal lobe [1,2] and the white matter that connects these parietal and prefrontal regions [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Prisms in Neglect Treatment: A Randomized Single Blind Study

Mancuso¹,

Capitani²

2016

Int J Phys Med Rehabil

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Objective: Unilateral Spatial Neglect (USN) commonly occurs after lesions in the right hemisphere. This complex syndrome can be defined as a failure to report, respond, or orient to contralateral stimuli. Patients show several symptoms in everyday life, such as eating only on the right side of the plate, or forgetting to look left before crossing the street.Among the different bottom-up treatments, prisms adaptation has found considerable application, producing a high number of scientific papers, even if these are not always consistent in their conclusions.The aim of this randomized single blind study was to verify the efficacy of prisms in improving neglect syndrome when compared to neutral lenses in a group of stroke in patients with neglect.Methods: All patients were randomized into two groups: Experimental Group (EG) and Control Group (CG). The EG was treated with pointing exercises wearing prismatic lenses producing a deviation of the visual field of 10° to the right, while the CG was treated with pointing exercises wearing neutral lenses that did not produce any deviation of the visual field. Both groups were treated for two weeks.We compared with Analysis of Variance the two groups of stroke patients at two different treatment times, at the enrollment time (T0) and after two weeks (T1). Results:We have compared the EG and CG at T0 and T1 time: both groups show a significant improvement in outcome measure. The analysis between groups highlights that this effect can be related to the time rather than to the group of treatment. Conclusion:According to our results we can conclude that pointing with no visible arm is useful in neglect treatment and that prisms produce some further benefits even if the low number of subjects enrolled is still insufficient to give clear evidence in the use of prisms.

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“…Patients are more likely to suffer from spatial neglect if the stroke damages specific areas within the brain such as the white matter tracts in the prefrontal cortex (Doricchi, Thiebaut de Schotten, Tomaiuolo, & Bartolomeo, 2008), the temporo-parietal junction and surrounding cortical areas (Mort et al, 2003) or the perisylvian areas (Kanath, Fruhmann, Kuker, & Rorden, 2004).…”

Section: Introductionmentioning

confidence: 99%

A Systematic Research Review Assessing the Effectiveness of Pursuit Interventions in Spatial Neglect Following Stroke

Hill

Coats

Halstead

et al. 2015

Transl. Stroke Res.

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BACKGOUND: Rehabilitation after stroke is imperative for patients with spatial neglect as it can help improve behavioural, social and cognitive outcomes in these patients, and therefore reduce the financial burden on public health services. The main aim of this review is to investigate the effectiveness of active pursuit eye movements for rehabilitation interventions in patients with spatial neglect following stroke. METHODS:Potential papers for inclusion were gathered by searching key terms in four main databases (AMED, Global Health, Pubmed/Medline and PsychInfo) in addition to screening relevant reference lists. Two reviewers independently selected papers for inclusion based on agreed inclusion criteria (n = 9 with 147 participants). Risk of bias was assessed using the QUADAS-2 tool. RESULTS:All papers reported a statistically significant result in patients who received an intervention which used pursuit eye movements, and this was reported both as a short term (immediate) effect and as a sustained effect up to eight weeks after treatment. These effects were also reported in comparison with interventions using saccadic eye movements. One study also reported increased neural activity in a number of brain regions following pursuit based intervention. CONCLUSIONS:Overall, there is good evidence in support of pursuit intervention used in the rehabilitation of stroke and spatial neglect over and above traditional interventions based on saccadic eye movements. Future research should aim to increase sample sizes, provide information on statistical power, record accurate eye movement responses, and use randomised designs to reduce selection bias.

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White matter (dis)connections and gray matter (dys)functions in visual neglect: Gaining insights into the brain networks of spatial awareness

Cited by 308 publications

References 76 publications

Brain Reorganization after Endovascular Treatment in a Patient with a Large Arteriovenous Malformation: The Role of Diagnostic and Functional Neuroimaging Techniques

Brain Reorganization after Endovascular Treatment in a Patient with a Large Arteriovenous Malformation: The Role of Diagnostic and Functional Neuroimaging Techniques

Efficacy of Prisms in Neglect Treatment: A Randomized Single Blind Study

A Systematic Research Review Assessing the Effectiveness of Pursuit Interventions in Spatial Neglect Following Stroke

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